In which condition is the 'Picture frame vertebra' seen?
Which condition is characterized by a 'moth-eaten' appearance of the bones?
Which condition is associated with the pencil in cup deformity?
What is the standard radiation dose to point A in the cervix for brachytherapy in the treatment of cervical cancer?
What is the echogenic lesion size criterion for chronic pancreatitis?
What is the CT scan finding in a carotid cavernous sinus fistula?
Frequency of ultrasound waves in USG -
Gyromagnetic property of proton is seen in -
Which imaging modality delivers the highest dose of radiation?
Which view is best for visualizing the collapse of the middle lobe of the lung?
NEET-PG 2013 - Radiology NEET-PG Practice Questions and MCQs
Question 21: In which condition is the 'Picture frame vertebra' seen?
- A. Paget disease (Correct Answer)
- B. Osteopetrosis (marble bone disease)
- C. Ankylosing spondylitis (AS)
- D. Osteoporosis
Explanation: ***Paget disease*** - The "picture frame vertebra" sign is a classic radiographic finding in **Paget disease**, characterized by **cortical thickening** and sclerosis around the vertebral body circumference, resembling a picture frame. - This appearance is due to the disordered bone remodeling processes (increased osteoclastic bone resorption followed by disorganized osteoblastic new bone formation) characteristic of Paget disease. *Osteopetrosis (marble bone disease)* - Osteopetrosis is characterized by **increased bone density** due to defective osteoclast function, leading to bones that are dense but brittle. - It does not typically present with the specific "picture frame" appearance of individual vertebrae, but rather with diffuse sclerosis of bones. *Ankylosing spondylitis (AS)* - Ankylosing spondylitis primarily affects the **axial skeleton**, causing inflammation and eventual fusion of the vertebrae (leading to a "bamboo spine" appearance). - While it involves the spine, it does not produce the "picture frame" vertebral sign seen in Paget disease. *Osteoporosis* - Osteoporosis is characterized by **reduced bone mass** and microstructural deterioration of bone tissue, leading to increased bone fragility and fracture risk. - Radiographically, it shows **decreased bone density** and possible vertebral compression fractures, which is the opposite of the increased bone density and cortical thickening seen in the "picture frame" sign.
Question 22: Which condition is characterized by a 'moth-eaten' appearance of the bones?
- A. Osteoid osteoma
- B. Multiple myeloma (Correct Answer)
- C. Eosinophilic granuloma
- D. Chondromyxoid fibroma
Explanation: ***Multiple myeloma*** [1][2] - Characterized by **punched-out lytic lesions** in bones, often described as **moth-eaten** appearance on imaging [1]. - Associated with **elevated serum proteins** and **Bence Jones proteins** in urine, confirming the diagnosis [2]. *Eosinophilic granuloma* - Usually presents with **solitary bone lesions** and is linked to **Langerhans cell histiocytosis** rather than the moth-eaten pattern. - Does not typically cause generalized **lytic bone lesions** seen in cases of multiple myeloma. *Chondromyxoid fibroma* - Generally appears as a **well-defined cortical lesion** and is not associated with a moth-eaten appearance. - It predominantly affects the **metaphysis** of long bones and shows a characteristic **cartilaginous matrix**. *Osteoid osteoma* - Presents with a **nidus** of osteoid formation, leading to localized bone pain, and does not exhibit a moth-eaten consistency. - Tends to cause **cortical bone thickening** rather than the diffuse lytic lesions associated with multiple myeloma. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus, p. 608. [2] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Blood And Bone Marrow Disease, pp. 616-617.
Question 23: Which condition is associated with the pencil in cup deformity?
- A. Rheumatoid arthritis
- B. Ankylosing spondylitis
- C. Avascular necrosis
- D. Psoriatic arthritis (Correct Answer)
Explanation: ***Psoriatic arthritis*** - The **pencil-in-cup deformity** is a classic radiographic finding in advanced psoriatic arthritis, occurring due to **periarticular bone erosion** and phalangeal telescoping. - This specific deformity is characterized by the proximal phalanx eroding and fitting into the expanded distal phalanx, resembling a "pencil in a cup." *Rheumatoid arthritis* - While rheumatoid arthritis causes significant joint destruction, it typically presents with **periarticular erosions** and **joint space narrowing**, but not the characteristic pencil-in-cup morphology. - Common deformities include **swan-neck** and **boutonnière** deformities, and ulnar deviation. *Ankylosing spondylitis* - This condition primarily affects the **axial skeleton**, leading to spinal fusion and **sacroiliitis**. - Peripheral joint involvement is less common and typically does not result in the pencil-in-cup deformity; instead, it can cause **syndesmophytes**. *Avascular necrosis* - **Avascular necrosis** (AVN) involves the death of bone tissue due to lack of blood supply, primarily affecting the femoral head or other major joints. - Radiographic findings include **subchondral collapse**, crescent sign, and eventual joint destruction, but not the specific deformities seen in inflammatory arthritis like pencil-in-cup.
Question 24: What is the standard radiation dose to point A in the cervix for brachytherapy in the treatment of cervical cancer?
- A. 8000 rad (Correct Answer)
- B. 6000 rad
- C. 10000 rad
- D. 4000 rad
Explanation: ***8000 rad*** - The standard **total cumulative radiation dose** to **Point A** in the cervix for the treatment of cervical cancer is approximately **8000 rad (80 Gy)**. - This represents the **combined dose** from external beam radiation therapy (EBRT, typically 45-50 Gy) plus intracavitary brachytherapy (typically 30-40 Gy to Point A). - Point A is a classical reference point defined as **2 cm superior to the external cervical os and 2 cm lateral to the uterine canal**, representing the location where the uterine artery crosses the ureter. - This total dose aims to provide adequate tumor control while minimizing toxicity to surrounding organs like the bladder and rectum. *6000 rad* - A total dose of **6000 rad** is insufficient for definitive local control of cervical cancer. - This dose is below the therapeutic threshold and would result in significantly higher rates of local recurrence and treatment failure. - Adequate doses are essential for curative intent in cervical cancer management. *10000 rad* - A dose of **10000 rad** to Point A would be excessively high and significantly increase the risk of severe acute and late toxicities to surrounding tissues. - Such a high dose could lead to serious complications including **rectovaginal or vesicovaginal fistulas, proctitis, cystitis, bowel strictures, and tissue necrosis**. - The therapeutic window would be exceeded, causing more harm than benefit. *4000 rad* - A dose of **4000 rad** would be substantially lower than the standard therapeutic dose for cervical cancer. - This suboptimal dose would likely result in **inadequate tumor control and increased risk of local recurrence**. - It is far below the dose required for curative treatment of cervical cancer.
Question 25: What is the echogenic lesion size criterion for chronic pancreatitis?
- A. > 2 mm
- B. > 3 mm (Correct Answer)
- C. > 1 mm
- D. > 4 mm
Explanation: ***> 3 mm*** - An echogenic lesion **greater than 3 mm** in size is a diagnostic criterion for **chronic pancreatitis** when observed on ultrasound imaging. - This represents one of the **major features** in ultrasound diagnosis of chronic pancreatitis, particularly when echogenic foci demonstrate acoustic shadowing (suggesting calcifications). - This criterion is part of established diagnostic frameworks and helps differentiate pathological calcifications from minor, non-specific findings. *> 4 mm* - While a **4 mm threshold** would indicate significant findings, the established diagnostic criterion for chronic pancreatitis uses **> 3 mm** as the cutoff. - Using a higher threshold would reduce sensitivity for detecting chronic pancreatitis. *> 2 mm* - A lesion larger than **2 mm** is generally considered below the established diagnostic threshold for **chronic pancreatitis**. - This size may represent early changes or incidental findings that are not yet definitive for diagnosis. *> 1 mm* - A lesion **greater than 1 mm** is too small to be a definitive criterion for **chronic pancreatitis** and could represent minor, non-pathological findings. - Such small echogenic foci lack sufficient specificity for diagnosing chronic pancreatic disease.
Question 26: What is the CT scan finding in a carotid cavernous sinus fistula?
- A. Enlarged superior ophthalmic vein (Correct Answer)
- B. Enlarged inferior ophthalmic vein
- C. Enlarged superior ophthalmic artery
- D. Enlarged inferior ophthalmic artery
Explanation: ***Enlarged superior ophthalmic vein*** * A carotid cavernous sinus fistula (CCSF) causes **high-pressure arterial blood** to shunt into the **venous system** of the cavernous sinus. * This increased pressure leads to retrograde flow and congestion in the draining veins, most notably the **superior ophthalmic vein**, causing its dilation. *Enlarged inferior ophthalmic vein* * While the inferior ophthalmic vein can also be involved in some cases of CCSF, the **superior ophthalmic vein** is typically more prominent and consistently affected due to its primary drainage pathway. * The inferior ophthalmic vein is less frequently the primary or most notable imaging finding compared to the superior ophthalmic vein. *Enlarged superior ophthalmic artery* * A CCSF involves an abnormal connection between the **carotid artery** (an artery) and the **cavernous sinus** (a venous structure), leading to venous, not arterial, dilation. * Arteries in the orbital region, like the superior ophthalmic artery, would not typically enlarge as a direct result of increased venous pressure in the cavernous sinus. *Enlarged inferior ophthalmic artery* * Similar to the superior ophthalmic artery, the inferior ophthalmic artery is an **arterial structure** and would not enlarge due to a high-flow arteriovenous shunt within the cavernous sinus. * The pathological changes in CCSF are primarily observed in the **venous drainage pathways**.
Question 27: Frequency of ultrasound waves in USG -
- A. 2000 Hz
- B. 5000 Hz
- C. < 2 MHz
- D. >2 MHz (Correct Answer)
Explanation: ***>2 MHz*** - Medical diagnostic ultrasound typically uses frequencies in the **range of 2-15 MHz**, with some applications extending from 1-20 MHz. - Frequencies **above 2 MHz** are considered the standard for diagnostic ultrasonography, providing adequate **spatial resolution** and tissue penetration for imaging internal structures. - **Frequency selection** depends on the application: - **2-5 MHz**: Deep structures (abdominal, obstetric imaging) - better penetration - **5-10 MHz**: Vascular studies, cardiac imaging - **7-15 MHz**: Superficial structures (thyroid, breast, musculoskeletal) - better resolution - Higher frequencies provide better resolution but less penetration; the choice represents a trade-off based on clinical needs. *2000 Hz* - This frequency (2 kHz) falls within the **audible range** for humans (20 Hz to 20 kHz). - Such low frequencies would not provide the necessary **spatial resolution** for diagnostic imaging and lack the characteristics needed for medical ultrasound. *5000 Hz* - At 5 kHz, this is still within the **audible frequency range**. - These frequencies are far too low for medical ultrasound imaging, which requires **megahertz frequencies** to generate diagnostically useful images with adequate detail. *< 2 MHz* - Frequencies below 2 MHz, while technically ultrasound (>20 kHz), are generally **below the diagnostic range** for most clinical applications. - Although lower frequencies offer better tissue penetration, frequencies below 2 MHz provide **insufficient spatial resolution** for standard diagnostic medical imaging.
Question 28: Gyromagnetic property of proton is seen in -
- A. MRI (Correct Answer)
- B. CT
- C. PET scan
- D. USG
Explanation: ***MRI*** - Magnetic Resonance Imaging (MRI) relies on the **gyromagnetic properties of protons**, primarily hydrogen nuclei in water and fat. - These protons align with a strong magnetic field and, when pulsed with radiofrequency waves, emit detectable signals that form the image. *CT* - Computed Tomography (CT) utilizes **X-rays** and their differential absorption by various tissues to create cross-sectional images. - It does not involve the gyromagnetic properties of protons. *PET scan* - Positron Emission Tomography (PET) scans detect **gamma rays** emitted from radiotracers, typically radionuclides like Fluorine-18, that accumulate in metabolically active tissues. - This imaging modality is based on radioactive decay, not proton spin. *USG* - Ultrasonography (USG) generates images by sending **high-frequency sound waves** into the body and detecting the echoes that bounce back from various tissues. - It relies on acoustic properties and tissue interfaces, not magnetic properties of protons.
Question 29: Which imaging modality delivers the highest dose of radiation?
- A. Cardiac perfusion scan (Correct Answer)
- B. CT scan of the chest
- C. Mammogram
- D. CT scan of the brain
Explanation: ***Cardiac perfusion scan*** - A **cardiac perfusion scan (nuclear cardiology)** involves the administration of a radioactive tracer, and the radiation dose can be significant due to the nature and energy of the isotopes used. - While varying, the effective dose for these scans can range from **10 to 30 mSv**, placing it among some of the highest radiation exposures from medical imaging. *CT scan of the chest* - A **CT scan of the chest** provides a relatively high radiation dose compared to plain X-rays, typically ranging from **5 to 7 mSv**. - This is generally lower than some nuclear medicine studies, particularly complex or prolonged cardiac perfusion scans. *Mammogram* - A **mammogram** involves a relatively low dose of radiation, typically in the range of **0.2 to 0.7 mSv**. - Its objective is to image the breast tissue with minimal exposure, making it one of the lower-dose imaging modalities available. *CT scan of the brain* - A **CT scan of the brain** usually delivers a moderate radiation dose, estimated to be around **1 to 2 mSv**. - This is often less than a chest CT due to the smaller volume and different shielding considerations, and significantly less than a cardiac perfusion scan.
Question 30: Which view is best for visualizing the collapse of the middle lobe of the lung?
- A. Anteroposterior (AP)
- B. Oblique
- C. Lateral (Correct Answer)
- D. Lordotic
Explanation: ***Lateral*** - A **lateral chest X-ray** is crucial for localizing abnormalities to specific lung lobes because it allows for a clear visualization of the **fissures** which define the lung lobes. - Collapse of the right middle lobe is particularly well-visualized on a lateral view as a **triangular opacity** that points towards the hilum, often obliterating the right heart border. *Anteroposterior (AP)* - While an AP or PA view can show collapse, it often appears as a **non-specific wedge or triangular opacity** and struggles with precise lobar localization due to superimposed structures. - The **heart shadow and mediastinum** can obscure parts of the middle lobe, making definitive diagnosis challenging from this view alone. *Oblique* - Oblique views are typically used for specific purposes, such as evaluating the **pleura** or **ribs**, and are not a standard view for initial assessment of lobar collapse. - They introduce **distortion and superimposition** that can make the identification and characterization of lobar collapse more difficult than a standard lateral projection. *Lordotic* - A lordotic view is primarily used to visualize the **lung apices** and to differentiate apical lesions from superimposed clavicular shadows. - It is not effective for visualizing the middle lobe, which is located more inferiorly, and would introduce significant distortion, making assessment of its collapse unreliable.