Question 1

Question

A viral particle is isolated from the cerebrospinal fluid of a 22-year-old immunocompetent college student presenting with aseptic meningitis, photophobia, and a maculopapular rash that began on the trunk and spread to the extremities. The particle is approximately 70 nm in diameter, icosahedral, non-enveloped, and contains a single-stranded positive-sense RNA genome. Which of the following best identifies this virus and its mechanism of central nervous system entry?

Accepted Answer

An enterovirus that spreads hematogenously to the meninges following primary replication in the gastrointestinal tract

Answer

A herpesvirus that undergoes retrograde axonal transport from peripheral sensory ganglia to the CNS

Answer

An arbovirus that crosses the blood-brain barrier after amplification in an arthropod vector inoculation site

Answer

A paramyxovirus that spreads trans-synaptically after initial respiratory mucosal infection

Answer

A parvovirus that infects CNS progenitor cells directly via the choroid plexus during viremia

Microbial genetics and drug resistance — MCQs

Microbial genetics and drug resistance — MCQs

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