Question 1

Question

A peripheral blood smear from a 45-year-old woman with a 2-week history of fatigue, jaundice, and confusion is shown. She was recently started on ticlopidine following coronary stent placement. Her laboratory values include: hemoglobin 7.1 g/dL, platelets 18,000/µL, creatinine 2.8 mg/dL, LDH 980 U/L, and indirect bilirubin 3.4 mg/dL. Direct Coombs test is negative. The image demonstrates the most diagnostically discriminating finding. Based on the peripheral smear finding and the complete clinical picture, what is the most likely diagnosis?

Accepted Answer

Thrombotic thrombocytopenic purpura precipitated by ticlopidine

Answer

Immune thrombocytopenic purpura with concurrent hemolytic anemia

Answer

Disseminated intravascular coagulation secondary to occult sepsis

Answer

Heparin-induced thrombocytopenia with thrombosis syndrome

Answer

Evans syndrome with autoimmune hemolytic anemia and thrombocytopenia

Screening guidelines — MCQs

Screening guidelines — MCQs

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