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A 58-year-old woman presents with a 10-day history of progressively worsening exertional dyspnea and bilateral leg swelling. She has a history of hypertension treated with lisinopril for 6 years. She recently completed a 6-month course of doxorubicin-based chemotherapy for breast cancer, finishing 3 months ago. Temperature 37.0°C, blood pressure 148/92 mmHg, heart rate 102 bpm, oxygen saturation 91% on room air. JVP is elevated at 10 cm. Bibasilar crackles are present. An ECG shows sinus tachycardia with no ischemic changes. The chest radiograph image shown demonstrates the finding most critical to establishing the diagnosis. Which of the following is the most likely diagnosis?

A female presents with a 1 × 1 cm thyroid swelling. What is the next best step in management?
What is the most appropriate initial investigation for a solitary thyroid nodule (STN)?
A young patient presents to the OPD with recurrent colicky abdominal pain. Urine examination shows the presence of red blood cells (RBCs) and the following crystal shape in the figure. What is the most likely diagnosis?

An 11-year-old boy is brought to the emergency department 30 minutes after he was found screaming and clutching his head. He has had nausea and occasional episodes of vomiting for 1 week, fever and left-sided headaches for 2 weeks, and increasing tooth pain over the past 3 weeks. He has no history of ear or sinus infections. He is in moderate distress. His temperature is 38.7°C (101.7°F), pulse is 170/min, respirations are 19/min, and blood pressure is 122/85 mmHg. He is confused and only oriented to person. The pupils react sluggishly to light. Fundoscopic examination shows papilledema bilaterally. Extraocular movements are normal. Flexion of the neck causes hip flexion. Which of the following is the most likely diagnosis?
Symptom-based differential diagnosis approach
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System-based differential construction
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Probability ranking in differentials
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Common vs rare disease considerations
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Age and demographic considerations
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Pattern recognition in diagnosis
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Anatomical approach to differential diagnosis
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Syndrome recognition
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Refinement of differential with testing
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Interpreting diagnostic ambiguity
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Ruling in vs ruling out strategies
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Cognitive biases in differential construction
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Integration of diagnostic information
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