Question 1

Question

Two research groups independently study the same genetic variant's association with diabetes. Study A (n=5,000) reports OR=1.25, 95% CI: 1.05-1.48, p=0.01. Study B (n=50,000) reports OR=1.08, 95% CI: 1.02-1.14, p=0.006. Both studies are methodologically sound. Synthesize these findings to determine the most likely true effect and evaluate implications for clinical and research interpretation.

Accepted Answer

The true effect is likely modest (closer to Study B's estimate); Study A likely overestimated due to smaller sample size, but both show statistical significance with clinically marginal effects

Answer

Study B is definitive because of its larger sample size and should replace Study A's findings

Answer

The study with the lower p-value (Study B) is automatically more reliable

Answer

The studies are contradictory and no conclusions can be drawn

Answer

Study A is correct because it was published first

P-values and confidence intervals — MCQs

P-values and confidence intervals — MCQs

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