General Surgery Principles — MCQs

Q: Splenectomy is done to tide over the acute crises of uncontrollable:

ITP. **Explanation:** **1. Why ITP is the Correct Answer:** Immune Thrombocytopenic Purpura (ITP) is an autoimmune condition where IgG autoantibodies coat platelets, leading to their premature destruction by splenic macrophages. In **acute, life-threatening crises** (such as intracranial or gastrointestinal hemorrhage) where medical management (steroids, IVIG, or platelet transfusions) fails to stabilize the patient, an **emergency splenectomy** is performed. Removing the spleen eliminates both the primary site of platelet destruction and a major source of autoantibody production, leading to a rapid rise in platelet counts. **2. Why Other Options are Incorrect:** * **TTP (Thrombotic Thrombocytopenic Purpura):** The pathophysiology involves a deficiency of the ADAMTS13 enzyme, leading to microthrombi. The primary treatment is **Plasmapheresis (Plasma Exchange)**. Splenectomy is not indicated for acute crises and is rarely considered even in refractory cases. * **HUS (Hemolytic Uremic Syndrome):** This is primarily a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (often Shiga-toxin mediated). Treatment is supportive (dialysis, fluids); splenectomy has no role in its management. **3. Clinical Pearls for NEET-PG:** * **Indications for Splenectomy in ITP:** Failure of medical therapy (steroids are 1st line), contraindications to steroids, or emergency life-threatening bleeding. * **Vaccination Protocol:** For elective splenectomy, vaccinate **2 weeks before** surgery. For emergency splenectomy (like in acute ITP crisis), vaccinate **2 weeks after** surgery. * **Target Organisms:** *S. pneumoniae* (most common), *H. influenzae*, and *N. meningitidis*. * **Post-Splenectomy Blood Picture:** Look for **Howell-Jolly bodies** (most characteristic), Pappenheimer bodies, Heinz bodies, and target cells.

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