UPSC-CMS 2020 - Pathology PYQs Practice Questions

Q: Common trisomies resulting in spontaneous abortion are all EXCEPT:

Trisomy 1. ***Trisomy 1*** - **Trisomy 1** is considered **lethal** and results in very early embryonic demise, often before a pregnancy is recognized, making it an extremely rare finding in spontaneous abortions. - The presence of an extra copy of such a large, gene-rich chromosome is **incompatible with early development**. *Trisomy 21* - **Trisomy 21 (Down syndrome)** is the most common autosomal trisomy that can result in a live birth, but it is also a frequent cause of **spontaneous abortion**. - While many pregnancies with Trisomy 21 result in live births, a significant proportion (approximately **75-80%**) end in miscarriage. *Trisomy 18* - **Trisomy 18 (Edwards syndrome)** is a common trisomy found in spontaneous abortions, second only to Trisomy 16. - While it can result in live births, the majority of fetuses with Trisomy 18 **miscarry spontaneously**. *Trisomy 16* - **Trisomy 16** is the most common trisomy identified in early spontaneous abortions, accounting for a large percentage of all chromosomal abnormalities leading to miscarriage. - It is considered **lethal** and is almost exclusively found in miscarried fetuses, with very rare exceptions of mosaic forms. [Practice more Pathology PYQs on OnCourse]

Question 1

All of the following are major subtypes of breast cancer based on Gene array analysis EXCEPT:

Accepted Answer

Estrogen receptor positive

Answer

Luminal A and Luminal B

Answer

Triple negative

Answer

Her-2 receptor positive

Question 2

Common trisomies resulting in spontaneous abortion are all EXCEPT:

Accepted Answer

Trisomy 1

Answer

Trisomy 21

Answer

Trisomy 18

Answer

Trisomy 16

UPSC-CMS 2020 — Pathology