NEET-PG 2018 Practice Questions

Q: Which of the following is NOT part of the special visceral efferent column?

Accessory nerve. ***Accessory nerve*** - The **accessory nerve (CN XI)** has two components: a **cranial part** and a **spinal part**. - The **spinal part** (which forms the main functional component) carries **somatic efferent fibers** to the **sternocleidomastoid** and **trapezius muscles** and is **NOT part of the special visceral efferent column**. - The cranial part briefly joins the vagus nerve and is functionally part of the vagus; the spinal accessory is the clinically and anatomically distinct component. - SVE specifically innervates muscles derived from **pharyngeal arches**, not muscles like SCM and trapezius. *Glossopharyngeal n* - The **glossopharyngeal nerve (CN IX)** contains **special visceral efferent fibers** that innervate the **stylopharyngeus muscle**, which is derived from the **third pharyngeal arch**. - These fibers originate from the **nucleus ambiguus**. *Nucleus ambiguus* - The **nucleus ambiguus** is a brainstem nucleus that contains the cell bodies of **special visceral efferent neurons**. - These neurons send axons through the **glossopharyngeal (CN IX), vagus (CN X)**, and **cranial part of accessory (CN XI) nerves** to innervate muscles of the pharynx and larynx derived from pharyngeal arches. *Vagus nerve* - The **vagus nerve (CN X)** carries **special visceral efferent fibers** that innervate muscles of the **pharynx** and **larynx** involved in swallowing and speech. - These fibers originate from the **nucleus ambiguus** and supply muscles derived from the **fourth and sixth pharyngeal arches**.

Q: Which vitamin deficiency is associated with night blindness?

Vit. A. ***Vitamin A*** - **Vitamin A deficiency is THE classic cause of night blindness (nyctalopia)**, one of the earliest signs of deficiency - Vitamin A is essential for synthesis of **rhodopsin**, the photopigment in retinal rod cells responsible for vision in dim light - Deficiency leads to impaired dark adaptation and progressive loss of night vision - Other manifestations include **xerophthalmia, Bitot's spots, and keratomalacia** - This is a high-yield fact for NEET-PG examinations *Riboflavin (Vitamin B2)* - Riboflavin deficiency causes **oral-ocular-genital syndrome** - Clinical features include **angular stomatitis, cheilosis, glossitis, seborrheic dermatitis** - Eye manifestations include **corneal vascularization and photophobia**, NOT night blindness - Does NOT cause night blindness as a primary symptom *Thiamine (Vitamin B1)* - Thiamine deficiency causes **Beriberi** (wet and dry forms) and **Wernicke-Korsakoff syndrome** - Characterized by peripheral neuropathy, cardiac dysfunction, and CNS manifestations - Does NOT cause night blindness *Biotin (Vitamin B7)* - Biotin deficiency is rare and causes **dermatitis, alopecia, conjunctivitis** - Also causes neurological symptoms in severe deficiency - Does NOT cause night blindness

Q: Acute Hemorrhagic Conjunctivitis is primarily caused by which type of Enterovirus?

Enterovirus type 70. ***Enterovirus type 70*** - **Enterovirus type 70** is the most common cause of **Acute Hemorrhagic Conjunctivitis (AHC)**, particularly in epidemic outbreaks. - AHC presents with rapid onset of **ocular pain**, **redness**, **swelling**, and **subconjunctival hemorrhages**. *Enterovirus type 68* - **Enterovirus D68 (EV-D68)** is primarily known for causing **respiratory illnesses**, ranging from mild to severe, and is associated with acute flaccid myelitis. - While it can cause respiratory symptoms, it is not a primary cause of **Acute Hemorrhagic Conjunctivitis**. *Enterovirus type 69* - **Enterovirus type 69** is a rare serotype and is not typically associated with specific human diseases or large-scale outbreaks. - Unlike EV70, it is not recognized as a significant cause of **conjunctivitis**. *Enterovirus type 71* - **Enterovirus A71 (EV-A71)** is a common cause of **hand, foot, and mouth disease (HFMD)**, especially in children, and can also lead to severe neurological complications. - While it causes various infections, it is not the primary cause of **hemorrhagic conjunctivitis**.

Q: Cutaneous larva migrans is caused by which organism?

Ancylostoma braziliense. ***Ancylostoma braziliense*** - This **hookworm** species commonly found in dogs and cats is the most frequent cause of **cutaneous larva migrans** in humans. - The larvae penetrate the skin but cannot complete their life cycle in humans, instead migrating aimlessly creating **serpiginous tracks**. *Strongyloides* - **_Strongyloides stercoralis_** causes **strongyloidiasis**, which presents with a rapidly advancing (up to 10 cm/hr) migratory rash known as **larva currens**, and not the slower cutaneous larva migrans. - It differs from cutaneous larva migrans in its ability to complete its life cycle in humans, leading to **autoinfection**. *Toxocara canis* - **_Toxocara canis_** is the causative agent of **visceral larva migrans** and **ocular larva migrans**, not cutaneous larva migrans. - In visceral larva migrans, larvae migrate through internal organs, causing symptoms like **hepatomegaly** and **eosinophilia**. *Necator americanus* - This is a human hookworm that can cause **iron deficiency anemia** due to chronic blood loss in the intestines. - While its larvae can penetrate the skin, causing a transient itchy rash known as **ground itch**, they do not cause the prolonged, migratory cutaneous larva migrans.

Q: Dilatation & curettage (D&C) is contraindicated in-

Pelvic inflammatory disease (PID). ***Pelvic inflammatory disease (PID)*** - D&C is **contraindicated** in PID due to the high risk of **spreading pre-existing infection** from the cervix or vagina into the sterile uterine cavity and beyond. - This procedure can worsen the infection, potentially leading to **sepsis**, **tubo-ovarian abscesses**, or chronic pain. *Endometriosis* - D&C is not typically contraindicated in **endometriosis**, as it is sometimes used diagnostically to rule out other causes of abnormal uterine bleeding, though it isn't a treatment for endometriosis itself. - Endometriosis involves the presence of **endometrial tissue outside the uterus**, and a D&C performed on the uterus does not directly exacerbate this condition. *Ectopic pregnancy* - D&C is not contraindicated in **ectopic pregnancy**; however, it is not the primary treatment. - A D&C may be performed if the diagnosis of ectopic pregnancy is uncertain and to rule out an **intrauterine pregnancy** or retained products of conception. *Abnormal uterine bleeding* - D&C is frequently indicated and can be both **diagnostic and therapeutic** for abnormal uterine bleeding, especially to investigate causes like polyps, fibroids, or endometrial hyperplasia. - It helps in obtaining tissue for **histopathological examination** to guide further management.

Q: What are the effects of Progesterone-only pills?

All of the options may occur. ***All of the options may occur*** - Progesterone-only pills (POPs) work through **multiple complementary mechanisms** that collectively provide effective contraception. - All three effects occur simultaneously and contribute to the overall contraceptive efficacy of POPs. - Understanding these mechanisms helps explain why POPs are effective despite lower hormone doses compared to combined oral contraceptives. **Mechanism 1: May suppress ovulation** - POPs can **partially suppress ovulation**, preventing the release of an egg. - Traditional POPs suppress ovulation in approximately 40-60% of cycles, while newer desogestrel-containing POPs achieve higher rates (97-99%). - This effect depends on the dose and type of progestin used in the formulation. **Mechanism 2: Thins the lining of the uterus** - Progesterone causes **endometrial atrophy**, making the uterine lining thin and unsuitable for embryo implantation. - This hostile uterine environment acts as a backup contraceptive mechanism if ovulation and fertilization occur. - Endometrial changes occur consistently with POP use. **Mechanism 3: Thickens cervical mucus** - This is the **primary and most consistent mechanism** of POPs. - Progesterone significantly **increases cervical mucus viscosity** and reduces its quantity within hours of administration. - The thickened mucus creates a physical barrier that prevents sperm penetration, motility, and viability.

Q: Which drug decreases the bone resorption in osteoporosis?

Risedronate. ***Risedronate*** - **Risedronate** is a **bisphosphonate**, a class of drugs that inhibits osteoclast activity, thereby decreasing **bone resorption**. - By reducing the rate at which bone is broken down, it helps to preserve **bone mineral density** in patients with osteoporosis. *Teriparatide* - **Teriparatide** is a **parathyroid hormone analog** that primarily works by stimulating **osteoblast activity** to promote new bone formation. - While it treats osteoporosis, its primary mechanism is **anabolic** (bone building), not directly decreasing bone resorption as its main effect. *Cortisone* - **Cortisone** is a **glucocorticoid** that can actually *worsen* osteoporosis by increasing **bone resorption** and decreasing **bone formation** with long-term use. - It is used to treat inflammatory conditions, not to decrease bone resorption for osteoporosis. *Cimetidine* - **Cimetidine** is an **H2-receptor antagonist** used to reduce stomach acid production, commonly for conditions like GERD or ulcers. - It has no known effect on **bone metabolism** or **osteoporosis**.

Q: What is the physiological response of the kidney during shock?

Renal blood flow decreases. ***Renal blood flow decreases*** - During shock, the **primary and most fundamental** physiological change affecting the kidney is a marked **reduction in renal blood flow (RBF)**. - Shock triggers intense **sympathetic activation** and **renin-angiotensin system (RAS) activation**, causing preferential **vasoconstriction** of renal vessels to redirect blood to vital organs (brain, heart). - RBF can drop to as low as **20-30% of normal** in severe shock, making this the hallmark renal response. - This reduction in RBF is the **upstream event** that triggers all other renal changes during shock. *Perfusion of kidney decreases* - While technically correct, "decreased perfusion" is **essentially synonymous** with decreased blood flow in this context. - The term "renal blood flow" is the **standard physiological terminology** used in medical literature to describe this phenomenon, making it the more precise answer. *Afferent arteriole resistance increases* - This is a **mechanism** by which RBF decreases, not the overall response itself. - Increased afferent arteriolar resistance is **secondary** to sympathetic activation and angiotensin II effects during shock. - It describes the "how" rather than the "what" of the kidney's response. *GFR decreases* - GFR reduction is a **consequence** of decreased RBF and increased afferent arteriolar resistance. - While clinically important (oliguria/acute kidney injury), it's a **downstream effect** rather than the primary physiological response. - The relationship: ↓RBF → ↓Glomerular hydrostatic pressure → ↓GFR

Q: Which of the following statements about Alzheimer's disease is false?

Alzheimer's disease is curable.. ***Alzheimer’s disease is curable*** - Alzheimer's disease is currently **incurable**, and treatments primarily focus on managing symptoms and slowing disease progression. - Research is ongoing to find more effective treatments, but there is no known cure yet. *Alzheimer’s disease is a leading cause of cognitive decline.* - Alzheimer's disease is the **most common cause of dementia**, accounting for 60-80% of cases, making it a primary driver of cognitive decline in older adults. - The disease progressively damages brain cells, leading to a decline in memory, thinking, and reasoning abilities. *Alzheimer’s disease causes dementia.* - **Dementia** is the clinical syndrome characterized by significant cognitive decline, and Alzheimer's disease is the most common underlying cause. - The characteristic pathological changes in Alzheimer's (amyloid plaques and neurofibrillary tangles) lead to neuronal damage and the resulting dementia symptoms. *One in 10 people age 65 and older has Alzheimer’s disease* - This statement accurately reflects the prevalence of Alzheimer's disease, as approximately 11.3% of people aged 65 and older in the United States have Alzheimer's dementia. - The risk of developing Alzheimer's disease **increases with age**, making it more common in the older population.

Question 1

Which of the following is NOT part of the special visceral efferent column?

Accepted Answer

Accessory nerve

Answer

Nucleus ambiguus

Answer

Glossopharyngeal n

Answer

Vagus nerve

Question 2

Which vitamin deficiency is associated with night blindness?

Accepted Answer

Vit. A

Answer

Biotin

Answer

Thiamine

Answer

Riboflavin

Question 3

Acute Hemorrhagic Conjunctivitis is primarily caused by which type of Enterovirus?

Accepted Answer

Enterovirus type 70

Answer

Enterovirus type 68

Answer

Enterovirus type 69

Answer

Enterovirus type 71

Question 4

Cutaneous larva migrans is caused by which organism?

Accepted Answer

Ancylostoma braziliense

Answer

Strongyloides

Answer

Toxocara canis

Answer

Necator americanus

Question 5

Dilatation & curettage (D&C) is contraindicated in-

Accepted Answer

Pelvic inflammatory disease (PID)

Answer

Endometriosis

Answer

Ectopic pregnancy

Answer

Abnormal uterine bleeding

Question 6

What are the effects of Progesterone-only pills?

Accepted Answer

All of the options may occur

Answer

May suppress ovulation

Answer

Thins the lining of the uterus

Answer

Thickens cervical mucus

Question 7

What is the mechanism of action of Curare drugs as muscle relaxants?

Accepted Answer

Act competitively on Ach receptors blocking post-synaptically

Answer

Persistently depolarizing at Neuromuscular junction

Answer

Repetitive stimulation of Ach receptors on muscle end plate

Answer

Inhibiting the calcium channel on presynaptic membrane

Question 8

Which drug decreases the bone resorption in osteoporosis?

Accepted Answer

Risedronate

Answer

Teriparatide

Answer

Cortisone

Answer

Cimetidine

Question 9

What is the physiological response of the kidney during shock?

Accepted Answer

Renal blood flow decreases

Answer

GFR decreases

Answer

Perfusion of kidney decreases

Answer

Afferent arteriole resistance increases

Question 10

Which of the following statements about Alzheimer's disease is false?

Accepted Answer

Alzheimer's disease is curable.

Answer

Alzheimer’s disease causes dementia.

Answer

Alzheimer’s disease is a leading cause of cognitive decline.

Answer

One in 10 people age 65 and older has Alzheimer’s disease

NEET-PG 2018

Anatomy

Biochemistry

Microbiology

Obstetrics and Gynecology

Pharmacology

Physiology

Psychiatry