NEET-PG 2015 Practice Questions

Q: Trigone of urinary bladder develops from:

Mesoderm. ***Mesoderm*** - The **trigone** of the urinary bladder develops from the **distal ends of the mesonephric (Wolffian) ducts**, which are **mesodermal in origin**. - These ducts are **absorbed into the posterior wall of the bladder**, forming the smooth triangular area between the two ureteric orifices and the internal urethral orifice [1]. - Although the epithelium of the trigone is later **replaced by endodermal epithelium** from the urogenital sinus, the **structural origin remains mesodermal**. - This is a classic example of **epithelial metaplasia** where endodermal epithelium replaces mesodermal tissue. *Endoderm of urachus* - The **urachus** is the fibrous remnant of the allantois that connects the apex of the bladder to the umbilicus. - It forms the **median umbilical ligament** in adults and does **not contribute to the trigone**. - The **urogenital sinus** (endodermal) forms the majority of the bladder body, but not the trigone. *Ectoderm* - The **ectoderm** forms the nervous system, epidermis, and sensory epithelia. - It does **not contribute** to the development of the urinary bladder or its trigone. - The urinary system is derived from **mesoderm** (kidneys, ureters, trigone) and **endoderm** (bladder body, urethra). *None of the options* - This is incorrect because **mesoderm** is the correct embryological origin of the trigone. - The mesonephric ducts that form the trigone are definitively mesodermal structures.

Q: Which type of pain is characterized by unknown etiology?

Idiopathic pain. ***Idiopathic pain*** - This term refers to pain where the **underlying cause** or pathology cannot be identified, despite thorough investigation. - It signifies that the **etiology is unknown**, fitting the description in the question directly. *Nociceptive pain* - This type of pain arises from the activation of **nociceptors** due to actual or threatened tissue damage. - Its etiology is typically clear, involving an injury, inflammation, or mechanical stress. *Neuropathic pain* - This pain results from damage or disease affecting the **somatosensory nervous system**. - The etiology is known to be nerve damage or dysfunction, not an unknown origin. *Inflammatory pain* - This pain is driven by the inflammatory process, involving the release of **pro-inflammatory mediators** at the site of tissue injury or infection. - The cause is directly linked to inflammation, making its etiology known.

Q: APAF-1 is involved in the activation of which of the following caspases?

Caspase 9. ***Caspase 9*** - **APAF-1** (Apoptotic Protease Activating Factor-1) is a key component of the **apoptosome**, which is formed in response to intrinsic apoptotic signals. - The apoptosome recruits and activates **pro-caspase 9**, leading to its proteolytic cleavage and activation into **caspase 9**. *Caspase 8* - **Caspase 8** is primarily involved in the **extrinsic apoptotic pathway**, activated by cell surface death receptors and DISC (Death-Inducing Signaling Complex) formation. - It is not directly activated by APAF-1, which is specific to the intrinsic pathway. *Caspase 10* - **Caspase 10** is also an initiator caspase often associated with the **extrinsic apoptotic pathway**, similar to caspase 8. - Its activation typically occurs within the DISC and not through the apoptosome complex involving APAF-1. *Caspase 3* - **Caspase 3** is an **effector caspase** that is activated by upstream initiator caspases (like caspase 9 or caspase 8) in both intrinsic and extrinsic apoptotic pathways. - While it's a crucial caspase in apoptosis, it is too far downstream and not directly activated by APAF-1; APAF-1 activates caspase 9, which then activates caspase 3.

Q: Which of the following syndromes is least likely to be associated with obesity?

Sipple syndrome. ***Sipple syndrome*** - Sipple syndrome, also known as **multiple endocrine neoplasia type 2**, is primarily associated with **medullary thyroid carcinoma** and does not typically correlate with obesity. - It includes signs like **pheochromocytoma** and **hyperparathyroidism**, but obesity is not a prominent feature. *Cushing syndrome* - Cushing syndrome leads to **excess cortisol**, commonly resulting in weight gain and central obesity [1]. - Characteristic features include **moon facies**, **buffalo hump**, and easy bruising, all associated with obesity [1]. *Pickwinian syndrome* - Pickwinian syndrome, characterized by **severe obesity**, is a condition primarily affecting physical stature and weight. - It is linked to **hypoventilation** and sleep apnea, reinforcing the presence of obesity. *Prader willi syndrome* - Prader-Willi syndrome is marked by **insatiable hunger** leading to **obesity** due to hypothalamic dysfunction [2]. - Individuals with this condition also demonstrate **hypotonia** and developmental delays, commonly accompanied by obesity [2]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Endocrine System, pp. 1127-1129. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Central Nervous System Synapse, pp. 454-455.

Q: A 50-year-old female presents with wrist drop. Which nerve is most likely involved?

Radial Nerve. ***Radial Nerve*** - **Wrist drop** is a classic symptom of **radial nerve** injury, which compromises the innervation of the **extensor muscles** of the wrist and fingers. - The radial nerve supplies motor function to the **triceps brahii**, brachioradialis, supinator, and the wrist and finger extensors. *Ulnar Nerve* - Injury to the ulnar nerve typically causes a **claw hand deformity** due to paralysis of the **interossei** and **lumbricals 3 and 4**, with sparing of the finger extensors. - Patients experience weakness in **finger adduction and abduction**, as well as sensory loss over the medial 1.5 digits and hypothenar eminence. *Median Nerve* - Median nerve injury often results in an **ape hand deformity** or **hand of benediction** (when attempting to make a fist), affecting muscles responsible for **thumb opposition** and **flexion of digits 2 and 3**. - It would not cause wrist drop, as the wrist extensors are innervated by the radial nerve. *Musculocutaneous Nerve* - Injury to the musculocutaneous nerve primarily affects the **biceps brachii** and **brachialis muscles**, leading to weakness in **elbow flexion** and **supination of the forearm**. - It does not innervate any muscles responsible for wrist extension or flexion, therefore it would not cause wrist drop.

Q: Neutralization test is

Nagler reaction. ***Nagler reaction*** - The **Nagler reaction** is a biochemical test used to identify **Clostridium perfringens**, based on its ability to produce **alpha-toxin (lecithinase)**, which hydrolyzes lecithin in egg yolk agar. - It is a neutralization test because the lecithinase activity can be **inhibited (neutralized)** by antitoxin, leading to a diminished zone of opalescence or turbidity around colonies grown on egg yolk agar. *Widal test* - The **Widal test** is an **agglutination test** used to diagnose **typhoid fever** by detecting antibodies against *Salmonella typhi* O and H antigens in a patient's serum. - It measures the presence of antibodies that cause bacterial clumping, not the neutralization of a toxin. *Weil-Felix test* - The **Weil-Felix test** is an **agglutination test** used to diagnose **rickettsial infections** like epidemic typhus, scrub typhus, and Rocky Mountain spotted fever. - It detects antibodies that cross-react with specific **Proteus vulgaris** antigens, and is not a neutralization assay for toxins or enzymes. *Paul Bunnel test* - The **Paul-Bunnell test** is an **agglutination test** used to diagnose **infectious mononucleosis** by detecting heterophile antibodies that agglutinate sheep red blood cells. - It relies on the clumping of red blood cells by antibodies and does not involve the neutralization of a microbial product.

Q: Which of the following is not considered an absolute contraindication for the use of an Intra Uterine Contraceptive Device (IUD)?

Uterine malformation. ***Uterine malformation*** - While a uterine malformation can make IUD insertion more difficult or reduce its effectiveness, it is often considered a **relative contraindication**, depending on the specific anomaly and the patient's desire for contraception. - In certain cases, an IUD might still be a viable option, but it requires careful consideration and specialized insertion techniques. *Pregnancy* - The presence of an existing pregnancy is an **absolute contraindication** for IUD insertion, as it can lead to complications such as miscarriage or ectopic pregnancy. - An IUD is a contraceptive device, and inserting it when a woman is already pregnant directly contradicts its purpose and poses significant risks. *Undiagnosed vaginal bleeding* - This is an **absolute contraindication** because it could be a symptom of a serious underlying condition, such as cervical cancer, endometrial cancer, or ectopic pregnancy. - Inserting an IUD before diagnosing the cause of the bleeding could delay treatment of a potentially life-threatening condition and exacerbate the bleeding. *Pelvic inflammatory disease* - Current or recent (within the last 3 months) **pelvic inflammatory disease (PID)** is an **absolute contraindication** due to the increased risk of worsening infection. - IUD insertion can introduce bacteria from the vagina into the uterus, potentially exacerbating an existing infection or causing a new one.

Q: Blebs are associated with which type of cell injury?

Both. ***Correct: Both*** - Blebs (surface membrane protrusions) are associated with **both reversible and irreversible cell injury** - In **reversible injury**: cellular swelling causes cytoskeletal disruption leading to bleb formation; these blebs can resolve if the injurious stimulus is removed - In **irreversible injury**: more extensive and widespread blebbing occurs during apoptosis and necrosis, associated with cell death pathways - The key difference is in the **extent and reversibility**, not the presence or absence of blebs *Incorrect: Reversible* - While blebs do occur in reversible injury, this option is incomplete as it excludes their occurrence in irreversible injury - Blebs are seen in both types of cellular injury, making "reversible" alone an inadequate answer *Incorrect: Irreversible* - While blebs are prominent in irreversible injury (apoptosis and necrosis), they also occur in reversible injury - Standard pathology texts (Robbins) describe bleb formation as a feature of cellular swelling in reversible injury - This option is incomplete as it excludes reversible injury *Incorrect: None of the options* - This is incorrect because blebs are definitively associated with cell injury (both reversible and irreversible types) - Bleb formation is a well-recognized morphological change in cellular pathology

Q: A woman firmly and persistently believes that her husband is cheating on her, despite any evidence to the contrary, and she disapproves of accepting any proof given in her husband's support. The other family members do not support her belief. This is an example of-

Delusion. ***Delusion*** - A **delusion** is a **fixed, false belief** that is not amenable to change in light of conflicting evidence. - The woman's persistent belief about her husband's infidelity, despite evidence to the contrary and disagreement from family members, fits the diagnostic criteria for a delusion. - This scenario specifically describes a **jealous delusion (Othello syndrome)**, where a person falsely believes their partner is unfaithful without any reasonable basis. - Key features: **firmly held**, **evidence-resistant**, **not shared by others** (non-bizarre delusion). *Illusion* - An **illusion** is a **misinterpretation of a real external stimulus**. - Example: Seeing a rope in dim light and thinking it's a snake. - In this case, there is no misperception of a real sensory stimulus; rather, it's a false belief held without basis in reality. *Hallucination* - A **hallucination** is a **sensory perception in the absence of an external stimulus**. - Examples include hearing voices when no one is speaking, or seeing objects that aren't present. - The woman is not experiencing false sensory perceptions; she is holding a fixed false belief about her husband's actions. *Perversion* - **Perversion** refers to a **deviation from what is considered normal**, often used in the context of sexual behavior or moral corruption. - This term does not describe a psychotic symptom or cognitive disorder like a delusion. - Not relevant to the clinical presentation of fixed false beliefs in psychiatric disorders.

Q: In which of the following conditions is Stereotactic Radiosurgery primarily indicated?

Arteriovenous malformation of the brain. ***Arteriovenous malformation of the brain*** - **Stereotactic Radiosurgery (SRS)** is a highly effective treatment for brain AVMs, particularly those that are **small to medium-sized** and located in eloquent brain regions. - SRS delivers a **highly focused dose of radiation** directly to the AVM, causing the abnormal blood vessels to gradually close off over time, reducing the risk of hemorrhage. *Medulloblastoma of the spinal cord* - Medulloblastoma is a **highly aggressive malignant brain tumor** that often metastasizes to the spinal cord via cerebrospinal fluid. - Treatment for spinal medulloblastoma typically involves **cranio-spinal irradiation with chemotherapy**, and SRS is generally not the primary treatment modality for diffuse spinal disease. *Ependymoma* - Ependymomas are tumors arising from the **ependymal cells** lining the ventricles and spinal cord. - While surgery is the primary treatment, radiotherapy, including **conventional fractionated external beam radiation**, is often used as adjuvant therapy, but SRS is less commonly the sole primary indication. *Glioblastoma multiforme* - Glioblastoma multiforme (GBM) is the **most aggressive primary brain tumor** and is typically treated with **maximal surgical resection followed by concurrent chemoradiotherapy**. - While SRS may be used in carefully selected cases for **recurrent GBM** or as a boost in primary treatment, it is not the primary solitary indication for initial management.

Question 1

Trigone of urinary bladder develops from:

Accepted Answer

Mesoderm

Answer

Ectoderm

Answer

None of the options

Answer

Endoderm of urachus

Question 2

Which type of pain is characterized by unknown etiology?

Accepted Answer

Idiopathic pain

Answer

Nociceptive pain

Answer

Neuropathic pain

Answer

Inflammatory pain

Question 3

APAF-1 is involved in the activation of which of the following caspases?

Accepted Answer

Caspase 9

Answer

Caspase 8

Answer

Caspase 10

Answer

Caspase 3

Question 4

Which of the following syndromes is least likely to be associated with obesity?

Accepted Answer

Sipple syndrome

Answer

Cushing syndrome

Answer

Prader willi syndrome

Answer

Pickwickian syndrome

Question 5

A 50-year-old female presents with wrist drop. Which nerve is most likely involved?

Accepted Answer

Radial Nerve

Answer

Ulnar Nerve

Answer

Median Nerve

Answer

Musculocutaneous Nerve

Question 6

Neutralization test is

Accepted Answer

Nagler reaction

Answer

Widal test

Answer

Weil-Felix test

Answer

Paul-Bunnell test

Question 7

Which of the following is not considered an absolute contraindication for the use of an Intra Uterine Contraceptive Device (IUD)?

Accepted Answer

Uterine malformation

Answer

Undiagnosed vaginal bleeding

Answer

Pregnancy

Answer

Pelvic inflammatory disease

Question 8

Blebs are associated with which type of cell injury?

Accepted Answer

Both

Answer

Reversible

Answer

Irreversible

Answer

None of the options

Question 9

A woman firmly and persistently believes that her husband is cheating on her, despite any evidence to the contrary, and she disapproves of accepting any proof given in her husband's support. The other family members do not support her belief. This is an example of-

Accepted Answer

Delusion

Answer

Illusion

Answer

Hallucination

Answer

Perversion

Question 10

In which of the following conditions is Stereotactic Radiosurgery primarily indicated?

Accepted Answer

Arteriovenous malformation of the brain

Answer

Ependymoma

Answer

Medulloblastoma of the spinal cord

Answer

Glioblastoma multiforme

NEET-PG 2015

Anatomy

Anesthesiology

Biochemistry

Internal Medicine

Microbiology

Obstetrics and Gynecology

Pathology

Psychiatry

Radiology