Inflammation and Repair Practice Questions

Q: Allergic asthma and rhinitis are related to which chemokine receptor?

CCR3. **Explanation:** The correct answer is **CCR3**. **Why CCR3 is correct:** Chemokine receptors are G-protein-coupled receptors that guide the migration of leukocytes. **CCR3** is highly and selectively expressed on **eosinophils**, basophils, and Th2 cells. It is the primary receptor for **eotaxin** (CCL11), a potent chemoattractant. In allergic conditions like asthma and rhinitis, Th2 cytokines (IL-4, IL-5) trigger the recruitment of eosinophils to the airway mucosa via the CCR3-eotaxin axis. This leads to eosinophilic inflammation, airway hyperresponsiveness, and mucosal edema, which are hallmarks of these diseases. **Why other options are incorrect:** * **CCR1:** Primarily expressed on monocytes and memory T cells. It binds to ligands like CCL3 (MIP-1α) and is involved in chronic inflammatory diseases like rheumatoid arthritis, but it is not the dominant receptor for allergic eosinophilia. * **CCR2:** This is the major receptor for **MCP-1** (Monocyte Chemoattractant Protein-1). It is essential for the recruitment of **monocytes** to sites of inflammation and is linked to atherosclerosis and insulin resistance. * **CCR5:** Expressed on T cells, macrophages, and dendritic cells. It is clinically significant as the **major co-receptor for M-tropic strains of HIV-1** (entry point into the cell). **High-Yield Pearls for NEET-PG:** * **CCR3:** Target for eosinophil recruitment (Asthma/Allergy). * **CCR5 & CXCR4:** Essential co-receptors for HIV entry. * **CXCR3:** Associated with Th1 responses and found on activated T cells. * **Eotaxin (CCL11):** The specific ligand for CCR3; its levels correlate with the severity of asthma.

Question 1

What governs the strength of a wound after 2 months?

Accepted Answer

Collagen cross-linking

Answer

Excess collagen deposition

Answer

Both collagen cross-linking and excess collagen deposition

Answer

None of the above

Question 2

Which of the following statements regarding wound healing is NOT true?

Accepted Answer

Stimulated by steroids

Answer

Impaired by radiation

Answer

Impaired by hematoma

Answer

Impaired by infection

Question 3

All of the following enzymes contribute to generating free oxygen radicals within neutrophils for killing intracellular bacteria, except?

Accepted Answer

Glutathione peroxidase

Answer

Superoxide dismutase

Answer

Fenton's reaction

Answer

NADPH oxidase

Question 4

Allergic asthma and rhinitis are related to which chemokine receptor?

Accepted Answer

CCR3

Answer

CCR1

Answer

CCR2

Answer

CCR5

Question 5

A 25-year-old machinist sustains an injury from a metal sliver in his left hand. Over the next few days, the wounded area becomes reddened, tender, swollen, and warm to the touch. The patient presents to the emergency room for removal of the sliver. Twenty-four hours later, endothelial cells at the site of injury release a chemical mediator that inhibits further platelet aggregation. What is this mediator of inflammation?

Accepted Answer

Prostaglandin (PGI2)

Answer

Plasmin

Answer

Serotonin

Answer

Thrombin

Question 6

Wound contraction is mediated by which of the following cells?

Accepted Answer

Myofibroblasts

Answer

Epithelial cells

Answer

Collagen

Answer

Elastin

Question 7

Rubor in inflammation is due to?

Accepted Answer

Dilation of arterioles

Answer

Increased vascular permeability

Answer

Increased viscosity of blood

Answer

Edema

Question 8

All of the following are true about C-reactive protein EXCEPT:

Accepted Answer

It is specific to pneumococcal infections.

Answer

CRP is a positive acute-phase reactant.

Answer

It belongs to the beta globin family.

Answer

CRP is so named because it precipitates with the C-Carbohydrate antigen of pneumococcus.

Question 9

Myofibroblasts are typically seen in which of the following locations?

Accepted Answer

Wound margin

Answer

Normal connective tissue

Answer

Muscle septa

Answer

Bronchus

Question 10

In the lipoxygenase pathway, which of the following arachidonic acid products helps in vasoconstriction and increased vascular permeability?

Accepted Answer

Leukotriene D4

Answer

C5a

Answer

Thromboxane A2

Answer

C, activators

Inflammation and Repair — MCQs

Inflammation and Repair — MCQs

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