Question 1

Question

A 22-year-old male presents with painless cervical lymphadenopathy, drenching night sweats, and a 6 kg weight loss over 3 months. CT scan shows mediastinal widening. Excisional lymph node biopsy is sent for histopathology. The biopsy image is shown (Image 2). Immunohistochemistry on the neoplastic cells would most likely demonstrate which of the following marker profiles?

Accepted Answer

A. CD15+, CD30+, CD45−, PAX5 dim positive, EBV-LMP1 positive in a subset

Answer

B. CD20+, CD10+, BCL2+, CD45+, TdT negative with t(14;18) translocation

Answer

C. CD3+, CD30+, ALK+, CD45+, EMA positive with t(2;5) translocation

Answer

D. CD20+, CD15−, CD30−, CD45+, BCL6+ with a germinal centre B-cell phenotype

Inflammation and Repair — MCQs

Inflammation and Repair — MCQs

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