Inflammation and Repair Practice Questions

Q: Which of the following is the WRONG combination regarding adhesion molecules and their corresponding CD markers?

PECAM - CD64. This question tests your knowledge of **Adhesion Molecules**, which are critical for leukocyte trafficking and the inflammatory response. In the NEET-PG exam, matching Cluster of Differentiation (CD) markers to their common names is a high-yield topic. ### **Explanation of the Correct Answer** **Option D (PECAM - CD64) is the WRONG combination.** * **PECAM-1** (Platelet Endothelial Cell Adhesion Molecule-1) is actually **CD31**. It is expressed on leukocytes and endothelial cells and is primarily responsible for **diapedesis** (transmigration of leukocytes through the endothelial junction) [1]. * **CD64** is the marker for **FcγRI**, the high-affinity receptor for IgG found on macrophages, monocytes, and neutrophils. ### **Analysis of Other Options** * **A. VCAM - CD106:** Correct. Vascular Cell Adhesion Molecule-1 (VCAM-1) is CD106. It binds to VLA-4 integrins on leukocytes and is involved in firm adhesion. * **B. ICAM - CD102:** Correct. Intercellular Adhesion Molecule-2 (ICAM-2) is CD102. It is constitutively expressed on endothelial cells. * **C. ICAM-1 - CD54:** Correct. ICAM-1 is CD54. It is upregulated by cytokines (TNF, IL-1) and is the ligand for LFA-1 (CD11a/CD18) during firm adhesion. ### **High-Yield Clinical Pearls for NEET-PG** * **Selectins (Rolling):** L-Selectin (CD62L), E-Selectin (CD62E), P-Selectin (CD62P). * **Integrins (Adhesion):** LFA-1 (CD11a/CD18) and MAC-1 (CD11b/CD18). * **LAD Type 1:** Caused by a deficiency in **CD18** (integrin β2 chain), leading to impaired firm adhesion and recurrent infections without pus formation [1]. * **LAD Type 2:** Caused by a deficiency in **Sialyl-Lewis X** (ligand for selectins), leading to impaired rolling. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Inflammation and Repair, pp. 87-89.

Question 1

VEGF is involved in all of the processes of angiogenesis except:

Accepted Answer

Enhances the production of ECM proteins

Answer

Migration and proliferation of endothelial cells

Answer

Capillary sprouting

Answer

Increased vascular permeability

Question 2

Which of the following mediators are involved in the resolution of inflammation?

Accepted Answer

TNF alpha, IL-10 and IL-1 receptor antagonist

Answer

TNF alpha, IL-1 and CRP

Answer

TNF beta, IL-6 and CRP

Answer

TNF gamma

Question 3

Pain in inflammation is mediated by?

Accepted Answer

Prostaglandins and bradykinins

Answer

Histamine and nitric oxide

Answer

Prostaglandins and interleukins

Answer

Interferons and free radicals

Question 4

Which of the following statements regarding hypertrophic scars is true?

Accepted Answer

Usually occurs across flexural areas

Answer

Does not improve with time

Answer

Overgrows its boundaries

Answer

Develops months after surgery

Question 5

ESR is a critical investigation in the diagnosis of TB. Which of the following is true about ESR in TB?

Accepted Answer

ESR is raised due to increased RBC aggregation

Answer

No change in ESR

Answer

Confirms recovery from TB

Answer

ESR is raised due to decreased RBC size

Question 6

Which of the following is the WRONG combination regarding adhesion molecules and their corresponding CD markers?

Accepted Answer

PECAM - CD64

Answer

VCAM - CD106

Answer

ICAM - CD102

Answer

ICAM1 - CD54

Question 7

All of the following are opsonins, except?

Accepted Answer

LTB4

Answer

IgG

Answer

C3b

Answer

Mannose binding lectin

Question 8

Which is the most potent chemotactic complement?

Accepted Answer

C5a

Answer

C5b

Answer

C4a

Answer

C2b

Question 9

A 34-year-old woman has a benign nevus removed from her back under local anesthesia. Which of the following families of cell adhesion molecules is the principal component of the "provisional matrix" that forms during early wound healing?

Accepted Answer

Fibronectins

Answer

Cadherins

Answer

Integrins

Answer

Laminins

Question 10

Which of the interleukins is responsible for endogenous pyrexia?

Accepted Answer

IL-1

Answer

IL-6

Answer

Interferon gamma

Answer

Interferon alpha

Inflammation and Repair — MCQs

Inflammation and Repair — MCQs

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