Immunopathology — MCQs

A routine complete blood count performed on a 22-year-old medical student reveals an abnormality in the differential leukocyte count. She has been complaining of frequent sneezing and "watery" eyes during the past several weeks and reports that she frequently had such episodes in the spring and summer. Which of the following cell types is most likely to be increased in the late phase reaction?

Which of the following hypersensitivity types cannot be detected by a skin test?

A 42-year-old man develops urticaria, stridor, and hypotension during a blood transfusion, requiring IV epinephrine. He has a history of frequent sinusitis and bronchitis. Which is the most likely immunologic deficiency?

A 51-year-old man presents with a palpable, nodular liver and symptoms of chronic illness. Laboratory tests reveal positive anti-HCV antibodies and negative HBsAg and HBcAg. A liver biopsy shows chronic hepatitis with severe activity and fibrosis. Despite a 6-month course of interferon, his condition deteriorates, necessitating an orthotopic liver transplantation. One year post-transplantation, he develops elevated transaminase and bilirubin levels. To minimize chronic rejection injury to hepatic endothelial cells, which component of the immune response should immunosuppressive therapy primarily target?

A 1-year-old girl with an inborn error of metabolism resulting in a lysosomal storage disease receives a hematopoietic stem cell transplant intended to replace her macrophage population. The gene of interest has a 'marker' small nucleotide polymorphism within a non-coding intron of the affected gene in which an A (patient gene) is substituted for a G (donor gene). She does quite well for the first 3 weeks. She tests positive for the missing enzyme, her previously abnormally enlarged organs begin to diminish in size, and assay of peripheral blood lymphocytes reveals increasing numbers of cells with the G polymorphism. However, the attending physicians are now concerned because repeated genetic testing reveals a progressive increase in lymphocytes with the A nucleotide polymorphism. Which of the following is the best explanation for this finding?

Early complement deficiency can manifest as?

Which of the following is an example of a Type III hypersensitivity reaction?

HLA DRw 52 is associated with which of the following conditions?

Regarding severe combined immunodeficiency, which of the following statements is true?

A 31-year-old man with AIDS complains of difficulty swallowing. Examination of his oral cavity demonstrates whitish membranes covering much of his tongue and palate. Endoscopy also reveals several whitish, ulcerated lesions in the esophagus. These pathologic findings are fundamentally caused by loss of which of the following immune cells?