Hematopathology Practice Questions

Q: Which of the following statements is not true about Von Willebrand disease?

Deficiency of VWF causes prolonged prothrombin time.. Explanation: **Why Option D is the correct (false) statement:** Von Willebrand Factor (VWF) is primarily involved in primary hemostasis (platelet adhesion) and the stabilization of Factor VIII. A deficiency in VWF leads to a prolonged **Bleeding Time (BT)** and potentially a prolonged **Activated Partial Thromboplastin Time (aPTT)** due to decreased Factor VIII levels [1]. However, it has no effect on the extrinsic pathway. **Prothrombin Time (PT)** measures the extrinsic and common pathways (Factors I, II, V, VII, X); since VWF does not interact with these factors, the PT remains **normal** in Von Willebrand Disease (vWD). **Analysis of other options:** * **Option A:** Correct. VWF is synthesized in **endothelial cells** (stored in Weibel-Palade bodies) and **megakaryocytes** (stored in α-granules of platelets). * **Option B:** Correct. VWF circulates in the plasma as multimers and is also present in the subendothelial connective tissue, where it awaits vascular injury to facilitate platelet binding. * **Option C:** Correct. VWF acts as a "bridge" between platelet GpIb receptors and subendothelial collagen (adhesion). It also serves as a carrier protein for **Factor VIII**, protecting it from rapid proteolytic degradation by Activated Protein C [1]. **High-Yield Clinical Pearls for NEET-PG:** * **Most Common:** vWD is the most common inherited bleeding disorder. * **Inheritance:** Most types (Type 1 and 2) are **Autosomal Dominant**, unlike Hemophilia (X-linked). * **Diagnostic Test:** The **Ristocetin Cofactor Assay** is the gold standard for functional assessment (measures VWF-dependent platelet agglutination) [1]. * **Treatment:** **Desmopressin (DDAVP)** is the treatment of choice for Type 1 as it releases endogenous VWF stores from endothelial cells [1].

Question 1

Which of the following is NOT a preliminary investigation for primary coagulation defects?

Accepted Answer

Prothrombin time

Answer

Bleeding time

Answer

Platelet count

Answer

Platelet aggregation studies

Question 2

Which of the following statements is not true about Von Willebrand disease?

Accepted Answer

Deficiency of VWF causes prolonged prothrombin time.

Answer

Von Willebrand factor (VWF) is synthesized by endothelial cells and megakaryocytes.

Answer

VWF may be located in the plasma and subendothelial tissue.

Answer

VWF causes platelet adhesion and prevents the degradation of factor VIII in plasma.

Question 3

A 26-year-old man has noted enlarging neck lumps for the past 6 months. Physical examination reveals enlarged, nontender right cervical lymph nodes. A biopsy of a lymph node microscopically shows macrophages, lymphocytes, neutrophils, eosinophils, and plasma cells. Scattered CD15+ large cells with multiple nuclei or a single nucleus with multiple nuclear lobes, each with a large inclusion-like nucleolus, are present. What is the most likely cell of origin and infectious agent for these large cells?

Accepted Answer

B lymphocyte, Epstein-Barr virus

Answer

CD4+ cell, human T lymphotropic virus

Answer

Endothelial cell, Kaposi sarcoma herpesvirus

Answer

Macrophage, human immunodeficiency virus

Question 4

Lacunar cells are seen in which subtype of Hodgkin's lymphoma?

Accepted Answer

Nodular sclerosis

Answer

Lymphocyte predominant Hodgkin's lymphoma

Answer

Lymphocyte depleted Hodgkin's lymphoma

Answer

Mixed cellularity

Question 5

Which of the following is NOT associated with Disseminated Intravascular Coagulation (DIC)?

Accepted Answer

Hyperfibrinogenemia

Answer

Thrombocytopenia

Answer

Prolonged Prothrombin Time (PT)

Answer

Increased Fibrin Degradation Products (FDP)

Question 6

All of the following genetic mutations are associated with an increased risk of deep venous thrombosis, EXCEPT:

Accepted Answer

Glycoprotein 1b platelet receptor defect

Answer

Factor V Leiden mutation

Answer

Heterozygous protein C deficiency

Answer

Prothrombin 20210G mutation

Question 7

Which of the following statements is NOT true about Immune Thrombocytopenic purpura (ITP)?

Accepted Answer

Increased megakaryocytes in bone marrow

Answer

Autoimmune mediated

Answer

Massive splenomegaly

Answer

Intravenous immunoglobulin is given

Question 8

A 41-year-old man presented with a 9-month history of cough, exertional dyspnea, nocturnal diaphoresis, and 10 kg weight loss. Physical examination revealed painless, massive, discrete, rubbery cervical, supraclavicular, and axillary lymphadenopathy. Chest radiography showed bilateral hilar lymphadenopathy. Serum calcium level was elevated at 16.2 mg/dL, with parathyroid hormone within the normal range. What is the most appropriate diagnostic investigation?

Accepted Answer

Excisional biopsy of the axillary node

Answer

Fine-needle aspiration cytology (FNAC) of the mediastinal lymph node

Answer

CT scan of the chest and abdomen

Answer

Core needle biopsy of the neck node

Question 9

What is the commonest site of lytic lesion in multiple myeloma?

Accepted Answer

Vertebral column

Answer

Femur

Answer

Clavicle

Answer

Pelvis

Question 10

Which congenital syndrome is associated with lymphoproliferative malignancy?

Accepted Answer

Chediak Higashi syndrome

Answer

Bloom syndrome

Answer

Fanconi's anemia

Answer

Turner syndrome

Hematopathology — MCQs

Hematopathology — MCQs

On this page

Practice by Chapter

Want unlimited practice?