Hematopathology — MCQs

Which of the following coagulation factors is deficient in classical hemophilia?

Stored blood as compared to fresh blood has:

A 61-year-old man presents with a several-month history of back pain. Radiographs of the spine reveal multiple 1-2 cm lytic lesions in the vertebral bodies. Physical examination shows no lymphadenopathy or splenomegaly. Serum chemistries reveal sodium 140 mmol/L, potassium 4.4 mmol/L, chloride 101 mmol/L, CO2 26 mmol/L, glucose 78 mg/dL, urea nitrogen 49 mg/dL, creatinine 5 mg/dL, total protein 8.3 g/dL, albumin 3.7 g/dL, alkaline phosphatase 176 U/L, AST 45 U/L, ALT 22 U/L, and total bilirubin 1.2 mg/dL. He recently developed a cough productive of yellowish sputum, and a sputum culture grew Streptococcus pneumoniae. During his hospitalization, a bone marrow biopsy is performed. What is the most likely finding on the bone marrow biopsy?

All are laboratory findings in iron deficiency anemia EXCEPT:

Polycythemia vera may transform into which of the following myeloid neoplasms?

A 3-year-old female child presented with skin papules. Which of the following is a marker of Langerhans cell histiocytosis?

What is the most common leukemia seen in individuals with Down syndrome?

A 30-year-old male develops tachycardia, hypotension (BP 70/40 mm Hg), and hematuria within 10 minutes of starting a blood transfusion in the OT. What is the most probable cause?

The parents of an 8-year-old boy complained of frequent severe bleeding on minor trauma. When they consulted a dentist for a decayed tooth, the dentist advised checking of prothrombin time (PT) and activated partial thromboplastin time (aPTT). What would be the expected results for PT and aPTT?

Birbeck granules in the cytoplasm are seen in which of the following cell types?