Hematopathology Practice Questions

Q: Arrange the following blood components in descending order of their shelf life:

Whole blood with CPD solution at 4 degrees C. To master blood banking for NEET-PG, it is essential to memorize the specific shelf lives determined by preservatives and storage temperatures. The shelf life of blood components is primarily dictated by the metabolic rate of cells and the biochemical stability of plasma proteins. ### **Analysis of Components (Descending Order of Shelf Life):** 1. **Fresh Frozen Plasma (FFP) at -18°C:** This has the longest shelf life of **1 year**. Freezing preserves coagulation factors (especially V and VIII) by halting enzymatic degradation. 2. **Whole Blood with CPDA-1 at 4°C:** The addition of **Adenine** to the Citrate Phosphate Dextrose (CPD) buffer allows for ATP regeneration, extending the shelf life to **35 days**. 3. **Whole Blood with CPD at 4°C:** Without adenine, the red cells exhaust their metabolic resources sooner, resulting in a shelf life of **21 days**. 4. **Platelets at 20-24°C:** These have the shortest shelf life of **5 days**. They must be stored at room temperature with constant agitation to maintain viability and prevent "storage lesions," but this increases the risk of bacterial growth. ### **Why the Question asks for the "Shortest" (Descending Order Logic):** The correct sequence from longest to shortest is: **FFP (1 year) > CPDA-1 (35 days) > CPD (21 days) > Platelets (5 days).** Therefore, in a descending list, **CPD (21 days)** is correctly placed after CPDA-1 and before Platelets. ### **High-Yield Clinical Pearls for NEET-PG:** * **SAGM (Saline-Adenine-Glucose-Mannitol):** Extends RBC shelf life to **42 days**. * **Cryoprecipitate:** Stored at -18°C for **1 year** (rich in Factor VIII, Fibrinogen, and vWF). * **Storage Lesion:** Refers to the decrease in pH, 2,3-DPG, and Sodium, and an **increase in Potassium** in stored blood. * **Temperature Check:** Platelets are the only routine component stored at room temperature (20-24°C).

Question 1

Disseminated intravascular coagulation (DIC) in association with giant hemangiomas is seen in which of the following conditions?

Accepted Answer

Kasabach-Merritt syndrome

Answer

Waterhouse-Friderichsen syndrome

Answer

Hemolytic Uremic Syndrome

Answer

Type 2 von Willebrand disease

Question 2

Multiple punched-out lesions in the skull are characteristically seen in which of the following conditions?

Accepted Answer

Multiple Myeloma

Answer

Thalassemia

Answer

Rickets

Answer

Osteoporosis

Question 3

HbA2 levels are increased in all of the following conditions EXCEPT:

Accepted Answer

Alpha Thalassemia

Answer

Beta Thalassemia

Answer

Sickle cell anemia

Answer

Megaloblastic Anemia

Question 4

Which of the following conditions can cause intravascular hemolysis?

Accepted Answer

Acute G6PD deficiency

Answer

Hereditary spherocytosis

Answer

Thalassemia

Answer

Paroxysmal nocturnal hemoglobinuria (PNH)

Question 5

Which cytogenetic abnormality is associated with a favourable prognosis in Acute Myeloid Leukemia (AML)?

Accepted Answer

t(8;21)

Answer

Deletion 5q

Answer

Preceding Myelodysplastic Syndrome (MDS)

Answer

Age less than 2 years

Question 6

Coagulation time is prolonged in all conditions except?

Accepted Answer

Idiopathic thrombocytopenic purpura (ITP)

Answer

Hemophilia

Answer

Von Willebrand's disease

Answer

Christmas disease

Question 7

A one-year-old boy presented with hepatosplenomegaly and delayed milestones. Liver biopsy and bone marrow biopsy revealed histiocytes with PAS-positive material. Electron microscopic examination of these histiocytes is most likely to reveal which of the following?

Accepted Answer

Birbeck granules in the cytoplasm

Answer

Myelin figures in the cytoplasm

Answer

Parallel arrays of tubular structures in lysosomes

Answer

Electron-dense deposits in the mitochondria

Question 8

According to the FAB classification, what is the minimum percentage of blast cells required for the diagnosis of Acute Myeloid Leukemia (AML)?

Accepted Answer

30%

Answer

20%

Answer

10%

Answer

40%

Question 9

Which of the following is false about hemolytic anemias?

Accepted Answer

Decreased erythropoietin levels

Answer

Jaundice is the main clinical sign

Answer

Shortened red cell life span

Answer

Increased reticulocyte count

Question 10

Arrange the following blood components in descending order of their shelf life:

Accepted Answer

Whole blood with CPD solution at 4 degrees C

Answer

Platelets at 20 degrees C

Answer

Fresh Frozen Plasma (FFP) at -18 degrees C

Answer

Whole blood with CPDA-1 solution at 4 degrees C

Hematopathology — MCQs

Hematopathology — MCQs

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