General Pathology Practice Questions

Q: Which of the following statements regarding coagulative necrosis is false?

Affected tissue has a cheese-like appearance.. **Explanation:** **Why Option D is the correct answer (False statement):** A "cheese-like" (friable, yellow-white) appearance is the hallmark of **Caseous necrosis**, not coagulative necrosis [1]. Caseous necrosis is typically seen in granulomatous inflammation, most notably in Tuberculosis [1]. In contrast, coagulative necrosis results in firm, opaque, and pale tissue. **Analysis of other options:** * **Option A (Most common type):** This is a true statement. Coagulative necrosis is the most frequent pattern of cell death encountered in clinical practice. * **Option B (Ischemia):** This is true. Ischemia (loss of blood supply) is the primary cause of coagulative necrosis in all solid organs except the brain (where ischemia leads to liquefactive necrosis). * **Option C (Tombstone appearance):** This is a classic histological description. In coagulative necrosis, the cell's structural framework is preserved for several days despite the loss of the nucleus. The cells appear as "ghostly" outlines or "tombstones" because the denaturation of proteins prevents immediate proteolysis. **NEET-PG High-Yield Pearls:** 1. **Mechanism:** The primary mechanism is the **denaturation of structural proteins and enzymes**, which blocks proteolysis (autolysis). 2. **Microscopy:** Characterized by increased eosinophilia (due to loss of cytoplasmic RNA) and nuclear changes (pyknosis → karyorrhexis → karyolysis). 3. **Exception Rule:** Ischemia in the **Brain** leads to **Liquefactive necrosis**, not coagulative. 4. **Clinical Example:** Myocardial Infarction (MI) is the most common clinical example of coagulative necrosis. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death, p. 55.

Question 1

All the following organs are likely to undergo coagulative necrosis except?

Accepted Answer

Brain

Answer

Spleen

Answer

Heart

Answer

Kidney

Question 2

Fibrinoid necrosis is typically seen in which of the following conditions?

Accepted Answer

Sarcoidosis

Answer

Polyarteritis nodosa

Answer

Systemic lupus erythematosus

Answer

Human immunodeficiency virus infection

Question 3

Which of the following statements regarding coagulative necrosis is false?

Accepted Answer

Affected tissue has a cheese-like appearance.

Answer

It is the most common type of necrosis.

Answer

Ischemia can lead to coagulative necrosis.

Answer

Affected tissue appears as a 'tombstone'.

Question 4

All of the following processes show features of acute inflammation except?

Accepted Answer

Apoptosis

Answer

Pyroptosis

Answer

Necroptosis

Answer

Necrosis

Question 5

Generation of free radicals occurs by all of the following mechanisms EXCEPT?

Accepted Answer

Reperfusion after ischemic injury

Answer

Normal metabolism

Answer

Oxygen toxicity

Answer

All of the above

Question 6

What is the most important change that occurs in irreversible cell injury?

Accepted Answer

Membrane damage

Answer

Decreased basophilia

Answer

Pyknosis

Answer

Accumulation of myelin figures

Question 7

What change is typically observed in mitochondria due to aging?

Accepted Answer

Decrease in both size and number

Answer

Decrease in size and increase in number

Answer

Decrease in number and increase in size

Answer

Increase in both size and number

Question 8

AE type of amyloid is seen in which of the following conditions?

Accepted Answer

Medullary carcinoma thyroid

Answer

Primary amyloidosis

Answer

Multiple myeloma

Answer

Familial amyloidosis

Question 9

A patient develops tachypnea, dyspnea, and tachycardia on day 3 following a femur fracture, progressing to delirium and coma. What is the most likely diagnosis?

Accepted Answer

Fat embolism

Answer

Acute respiratory distress syndrome

Answer

Deep vein thrombosis

Answer

Infarction

Question 10

What is Zenker's degeneration?

Accepted Answer

Coagulative necrosis

Answer

Liquefactive necrosis

Answer

Fibroid necrosis

Answer

Caseous necrosis

General Pathology — MCQs

General Pathology — MCQs

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