Question 1

Q: Osteosclerosis of bone occurs due to?

Increased host response. ### Explanation **Concept Overview:** Osteosclerosis refers to an abnormal increase in bone density, characterized by thickening of the trabeculae and narrowing of the medullary canal. In the context of infections (like chronic osteomyelitis), it represents a **productive or formative bone response** rather than a destructive one. **Why Option C is Correct:** Osteosclerosis occurs when the **host’s immune response is strong** and the infecting organism’s virulence is relatively low. This balance allows the body to contain the infection by stimulating osteoblastic activity, leading to the formation of dense, sclerotic bone. A classic clinical example is **Garré’s Sclerosing Osteomyelitis**, where the body reacts to a low-grade chronic infection by producing massive subperiosteal new bone and sclerosis without significant suppuration or sequestration. **Why Other Options are Incorrect:** * **Options A & D:** Decreased host resistance or an immunocompromised state typically leads to rapid, aggressive bone destruction (osteolysis) and systemic spread, rather than the organized, dense bone formation seen in sclerosis. * **Option B:** High virulence of an organism usually results in acute suppuration, abscess formation, and bone necrosis (sequestrum). Sclerosis is a hallmark of a chronic, low-grade process where the host is "winning" the battle or maintaining a stalemate. **High-Yield Clinical Pearls for NEET-PG:** * **Garré’s Sclerosing Osteomyelitis:** Most common in the mandible and tibia; characterized by "onion-skin" periosteal reaction and dense sclerosis. * **Brodie’s Abscess:** Another form of high host resistance where a subacute infection is localized and walled off by a rim of sclerotic bone. * **Radiological Sign:** On X-ray, osteosclerosis appears as increased radiopacity (whiteness) and loss of the normal trabecular pattern.

Question

Osteosclerosis of bone occurs due to?

Accepted Answer

Increased host response

Answer

Decreased host resistance

Answer

Increase in the virulence of organisms causing infection

Answer

Occurs in immunocompromised patients

Arthrology and Infections — MCQs

Arthrology and Infections — MCQs

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