Question 1

Question

A 22-year-old woman presents at 14 weeks of gestation with excessive nausea, uterine size larger than dates, and a serum beta-hCG of 450,000 mIU/mL. Ultrasound shows a 'snowstorm' appearance. Suction evacuation is performed and the specimen is sent for histopathological examination. The histopathology is shown in Image 1. Which of the following best describes the karyotype and mechanism of origin of this condition?

Accepted Answer

A. 46,XX or 46,XY arising from fertilization of an empty (anucleate) ovum by a single haploid sperm with subsequent duplication (monospermic), or by two spermatozoa (dispermic)

Answer

B. 69,XXX or 69,XXY arising from fertilization of a normal ovum by two spermatozoa

Answer

C. 46,XY arising from fertilization of a normal ovum by a single diploid sperm without duplication

Answer

D. 45,X arising from meiotic non-disjunction in the maternal gamete

Fertility and Infertility — MCQs

Fertility and Infertility — MCQs

On this page

Practice by Chapter

Want unlimited practice?