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A 32-year-old woman presents with a 5-day history of confusion, fever, and oliguria. Laboratory results show haemoglobin 7.2 g/dL, platelets 18,000/µL, creatinine 2.8 mg/dL, and markedly elevated LDH. Her coagulation profile (PT, aPTT, fibrinogen) is within normal limits. A peripheral blood smear is shown (Image 1). Which of the following is the most appropriate immediate intervention?

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