NEET-PG 2018 Practice Questions

Q: CT scan of abdomen showing a structure branching within the liver. Identify the structure.

Portal vein. ***Portal vein*** - The image shows a **branching vessel within the liver parenchyma**. The **portal vein** enters the liver at the porta hepatis and branches extensively to supply the liver with nutrient-rich, deoxygenated blood from the gastrointestinal tract. - On a CT scan, the portal vein and its branches appear as prominent, contrast-filled structures centrally located within the liver, consistent with the identified structure. *Superior Vena Cava* - The **superior vena cava** is located in the **chest**, superior to the diaphragm, and drains blood from the upper body into the right atrium; it does not branch within the liver. - This vessel would not be visible in an abdominal CT slice at this level and does not show intrahepatic branching. *Inferior Vena Cava* - The **inferior vena cava (IVC)** is a large vessel located **posterior to the liver**, collecting deoxygenated blood from the lower body and liver (via hepatic veins) before emptying into the right atrium. - While it is in the abdomen, it does not branch within the liver parenchyma in the same manner as the portal vein; rather, **hepatic veins** drain into it from the liver. *Splenic Vein* - The **splenic vein** runs along the **posterior aspect of the pancreas** and eventually joins with the superior mesenteric vein to form the portal vein outside the liver. - It does not enter or branch within the liver itself; its location is too far posterior and outside the liver to match the structure indicated.

Q: Galactosemia is due to deficiency of which enzyme?

Galactose-1-phosphate uridyltransferase. ***Galactose-1-phosphate uridyltransferase*** - Deficiency of **galactose-1-phosphate uridyltransferase (GALT)** leads to the most severe form, **classic galactosemia**. - This enzyme is crucial for converting **galactose-1-phosphate** to **glucose-1-phosphate** in the Leloir pathway. *HGPRT* - **HGPRT** (hypoxanthine-guanine phosphoribosyltransferase) deficiency causes **Lesch-Nyhan syndrome**, a distinct metabolic disorder. - Lesch-Nyhan syndrome is characterized by **hyperuricemia**, neurological dysfunction, and self-mutilation, unrelated to galactose metabolism. *Galactokinase* - Deficiency of **galactokinase** causes Type II galactosemia, a milder form than classic galactosemia. - This defect primarily leads to **cataracts** due to galactitol accumulation but does not result in the severe systemic issues seen in classic galactosemia. *Epimerase* - Deficiency of **UDP-galactose-4'-epimerase** (GALE) causes Type III galactosemia, which has a variable clinical presentation from mild to severe. - While involved in galactose metabolism, it's not the primary enzyme deficient in the most common and severe form of **galactosemia**.

Q: According to WHO classification, severe thinness is defined as a BMI below which value?

< 16. ***Correct: < 16 kg/m²*** - The WHO classifies **BMI < 16 kg/m²** as **severe thinness (Grade 3 thinness)** - This represents critically low body weight with significant health risks - Values like 12, 13, 14, or 15 all fall into this severe thinness category *18* - BMI **18.5-24.9 kg/m²** is classified as **normal/healthy weight** by WHO - BMI **17.0-18.49 kg/m²** is classified as **mild thinness (Grade 1)** - 18 is not the threshold for severe thinness *14* - 14 kg/m² is **an example of a value** that falls within severe thinness - However, the question asks for the **threshold/cutoff value**, which is **16 kg/m²** - Any BMI below 16 (including 14, 13, 12) indicates severe thinness *13* - Like option 14, this is **a value within** the severe thinness range - The **defining threshold** is **< 16 kg/m²**, not 13 - The question asks for the classification cutoff, not an example value within the range

Q: Which of the following constitutional articles is not related to children?

42. ***Article 42*** - Article 42 of the Indian Constitution deals with **provision for just and humane conditions of work** and **maternity relief**, primarily concerning adult workers, particularly women. - While maternity relief indirectly benefits children by supporting mothers, the article's direct focus is not on children's rights or welfare. *Article 23* - Article 23 prohibits **traffic in human beings and forced labor**, including **begar** and other forms of forced labor. - This article is directly related to children as it safeguards them from exploitation, such as **child trafficking** and forced labor. *Article 21-A* - Article 21-A guarantees the **right to education** for all children between the ages of six and fourteen years. - It mandates that the state shall provide free and compulsory education, making it fundamentally related to children's rights. *Article 24* - Article 24 prohibits the **employment of children below the age of fourteen years** in any factory or mine or engages them in any other hazardous employment. - This article directly protects children from various forms of child labor and is thus related to child welfare.

Q: In a patient presenting with an ECG that shows ST-segment elevation but with a myocardial stunning pattern that does not correspond to a single coronary artery territory, what is the most likely diagnosis?

Takotsubo cardiomyopathy. **Takotsubo cardiomyopathy** - This condition is often triggered by **severe emotional or physical stress** and presents with acute chest pain, mimicking an MI, but with a distinctive pattern of **apical ballooning** or other regional wall motion abnormalities that do not correspond to a single coronary artery territory. - The ECG findings of **ST-segment elevation** associated with a myocardial stunning pattern that does not follow a specific coronary artery distribution are classic for Takotsubo cardiomyopathy, which is also known as **stress-induced cardiomyopathy**. *Restrictive cardiomyopathy* - This is characterized by **stiff, non-compliant ventricular walls** causing impaired diastolic filling, often leading to heart failure symptoms. - While it can cause abnormal ECG findings, it typically does not present with **acute ST-segment elevation** or a myocardial stunning pattern in a non-coronary distribution. *Brugada syndrome* - This is a **genetic channelopathy** associated with characteristic **ECG patterns (ST-segment elevation in V1-V3)** and an increased risk of ventricular arrhythmias and sudden cardiac death. - It is primarily an **electrical disorder** and does not involve myocardial stunning or wall motion abnormalities that mimic an acute myocardial infarction without corresponding coronary artery disease. *Pericarditis* - This condition involves **inflammation of the pericardium**, presenting with chest pain that often improves when leaning forward and widespread, **concave ST-segment elevation** on ECG. - While it causes ST-segment elevation, it does not typically show the specific **myocardial stunning pattern** or regional wall motion abnormalities that are characteristic of Takotsubo cardiomyopathy.

Q: In a woman complaining of AUB following image was seen in endoscopic examination of uterus. What will be the diagnosis?

Leiomyoma. ***Leiomyoma*** - The image shows **well-circumscribed, smooth, rounded masses protruding into the uterine cavity**, which are characteristic of **submucous (intracavitary) leiomyomas (fibroids)** seen on hysteroscopy. - Submucous leiomyomas are benign smooth muscle tumors that project into the endometrial cavity and commonly cause **abnormal uterine bleeding (AUB)** due to increased endometrial surface area, distortion of the endometrial cavity, ulceration of overlying endometrium, and interference with normal uterine contractility. - On **hysteroscopic examination**, they appear as firm, pale, smooth-surfaced masses with overlying endometrium. *Adenomyosis* - Adenomyosis involves the presence of **endometrial tissue within the myometrium**, leading to diffuse uterine enlargement. - On hysteroscopy, it may show a **globally irregular endometrial surface** with small endometrial openings or cystic spaces, but not the discrete, well-circumscribed protruding masses seen in the image. - While it can cause AUB and dysmenorrhea, the appearance is distinctly different from submucous leiomyomas. *Ovarian neoplasm* - Ovarian neoplasms originate in the **ovaries**, which are separate from the uterus. - **Hysteroscopic examination** visualizes only the **endometrial cavity** and cannot directly visualize ovarian pathology. - Ovarian masses do not protrude into the uterine cavity. *Carcinoma of uterus* - Endometrial carcinoma typically presents on hysteroscopy as **irregular, friable, ulcerative, or fungating lesions** with abnormal vascularity and易出血 (easy bleeding). - The **smooth, well-defined, and rounded appearance** with intact overlying mucosa in the image is characteristic of benign leiomyomas, not malignant growths. - Uterine sarcomas are rare and would show more irregular, infiltrative features rather than well-circumscribed masses.

Q: Extramammary Paget's disease of the vulva is most commonly associated with which other cancer?

Vulvar cancer. ***Vulvar cancer*** - **Extramammary Paget's disease (EMPD)** frequently presents in the vulvar region and is associated with an underlying **adenocarcinoma** in up to 30% of cases. - The disease involves intraepithelial adenocarcinoma cells that can spread locally and, in some instances, indicates a synchronous or metachronous **internal malignancy**, often of genitourinary or gastrointestinal origin, but primarily vulvar adenocarcinoma in this context. *Vaginal cancer* - While Paget's disease can occur in other anogenital areas, its association with **primary vaginal cancer** is much less common compared to vulvar involvement. - **Vaginal Paget's disease** is rare and usually represents secondary spread from a vulvar primary or an underlying bladder/urethral carcinoma. *Cervical cancer* - **Paget's disease** is not typically associated with **cervical cancer**. Cervical cancers are predominantly squamous cell carcinomas or adenocarcinomas arising from the transformation zone. - While cervical adenocarcinoma can present with similar cells to Paget's, it is a distinct entity and not a common association. *Uterine cancer* - **Uterine cancer**, primarily endometrial carcinoma, has no direct or common association with **Paget's disease**. - Paget's disease primarily affects the skin and can be associated with underlying gland cancers, but these are generally in proximity to the epidermal involvement rather than distant uterine sites.

Q: Based on the provided image, which of the following is the correct diagnosis?

Unicornuate Uterus. ***Unicornuate Uterus*** - The image distinctly shows **only one fallopian tube and one rudimentary uterine horn** on the right side, indicating a unicornuate uterus. - This malformation results from the **incomplete development of one Müllerian duct**, leading to a single, banana-shaped uterine cavity. *Uterus didelphys* - This condition involves **two completely separate uteri**, each with its own cervix and vagina. - The image does not show evidence of two distinct uterine bodies or cervices. *Bicornuate Uterus* - A bicornuate uterus is characterized by **two uterine horns that fuse caudally**, creating a heart-shaped appearance with a shared cervix. - The image clearly lacks the characteristic heart shape and shows only one functional horn. *Septate uterus* - A septate uterus has a **fibrous or muscular septum** dividing the uterine cavity, while the external uterine contour remains normal. - The image does not show a septum or a normal external uterine contour with an internal division; instead, it presents with a single underdeveloped horn.

Q: Tadalafil should not be given with:

Vasodilators. ***Vasodilators*** - Tadalafil is a **phosphodiesterase-5 (PDE5) inhibitor** that causes **vasodilation** by increasing cGMP levels, leading to smooth muscle relaxation. - Combining tadalafil with other **vasodilators**, particularly **nitrates**, can lead to a severe and potentially life-threatening drop in **blood pressure (hypotension)**. *Antibiotics* - While some antibiotics, particularly macrolides or azoles, can inhibit **CYP3A4** and increase tadalafil levels, this interaction is typically managed by dose adjustments rather than an absolute contraindication. - The primary concern with administering antibiotics and tadalafil concurrently is **pharmacokinetic interactions**, not a direct pharmacodynamic synergy leading to acute, severe adverse effects. *Vasoconstrictors* - Vasoconstrictors have an effect **opposite** to tadalafil, as they narrow blood vessels. - There is generally no contraindication for co-administration, and in fact, tadalafil's **vasodilatory effects** could potentially **counteract** some of the vasoconstriction, although concurrent use is not typically recommended for erectile dysfunction. *Valproate* - **Valproate** is an **anticonvulsant** and mood stabilizer, and there is no significant or clinically relevant drug interaction established with tadalafil. - It does not share common metabolic pathways or pharmacodynamic effects that would lead to dangerous interactions with tadalafil.

Q: What is the cutoff for surgery in an abdominal aortic aneurysm in asymptomatic patients?

5.5cm. ***5.5cm*** - For **asymptomatic patients**, an abdominal aortic aneurysm (AAA) measuring **5.5 cm or larger** is generally considered the threshold for surgical repair. - This cutoff is based on studies showing that the risk of rupture significantly increases beyond this size, outweighing the risks of elective repair. *6.5cm* - While a 6.5 cm AAA would certainly warrant repair, the **standard cutoff for elective repair is 5.5 cm** to prevent rupture. - Delaying repair until this size would expose the patient to an unnecessarily higher risk of complications. *7.5cm* - An aneurysm of 7.5 cm carries a **very high risk of rupture**, making emergency repair almost inevitable if it is not addressed proactively. - This size is well beyond the recommended threshold for elective intervention. *8.5cm* - An 8.5 cm AAA has an **extremely high and imminent risk of rupture**, which would be a life-threatening event. - Surgical intervention would be considered urgent in this scenario, as it is far past the ideal window for elective repair.

Question 1

CT scan of abdomen showing a structure branching within the liver. Identify the structure.

Accepted Answer

Portal vein

Answer

Superior vena cava

Answer

Inferior vena cava

Answer

Splenic vein

Question 2

Galactosemia is due to deficiency of which enzyme?

Accepted Answer

Galactose-1-phosphate uridyltransferase

Answer

HGPRT

Answer

Galactokinase

Answer

Epimerase

Question 3

According to WHO classification, severe thinness is defined as a BMI below which value?

Accepted Answer

< 16

Answer

18

Answer

14

Answer

13

Question 4

Which of the following constitutional articles is not related to children?

Accepted Answer

42

Answer

23

Answer

24

Answer

21-A

Question 5

In a patient presenting with an ECG that shows ST-segment elevation but with a myocardial stunning pattern that does not correspond to a single coronary artery territory, what is the most likely diagnosis?

Accepted Answer

Takotsubo cardiomyopathy

Answer

Restrictive cardiomyopathy

Answer

Brugada syndrome

Answer

Pericarditis

Question 6

In a woman complaining of AUB following image was seen in endoscopic examination of uterus. What will be the diagnosis?

Accepted Answer

Leiomyoma

Answer

Adenomyosis

Answer

Ovarian neoplasm

Answer

Carcinoma of uterus

Question 7

Extramammary Paget's disease of the vulva is most commonly associated with which other cancer?

Accepted Answer

Vulvar cancer

Answer

Vaginal cancer

Answer

Cervical cancer

Answer

Uterine cancer

Question 8

Based on the provided image, which of the following is the correct diagnosis?

Accepted Answer

Unicornuate Uterus

Answer

Uterus didelphys

Answer

Bicornuate Uterus

Answer

Septate uterus

Question 9

Tadalafil should not be given with:

Accepted Answer

Vasodilators

Answer

Antibiotics

Answer

Vasoconstrictors

Answer

Valproate

Question 10

What is the cutoff for surgery in an abdominal aortic aneurysm in asymptomatic patients?

Accepted Answer

5.5cm

Answer

6.5cm

Answer

7.5cm

Answer

8.5cm

NEET-PG 2018

Anatomy

Biochemistry

Community Medicine

Internal Medicine

Obstetrics and Gynecology

Pharmacology

Surgery