Question 1

Q: Which of the following statements about methyl alcohol poisoning is incorrect?

Fomepizole competitively inhibits aldehyde dehydrogenase. ***Fomepizole competitively inhibits aldehyde dehydrogenase*** - **Fomepizole** acts as a competitive inhibitor of **alcohol dehydrogenase**, not aldehyde dehydrogenase. - By inhibiting alcohol dehydrogenase, fomepizole prevents the metabolism of methanol into toxic metabolites like formic acid. *Effects are due to formic acid* - This statement is correct. The primary toxicity of methanol poisoning is due to its metabolism into **formic acid** by alcohol and aldehyde dehydrogenases. - Formic acid is responsible for the **metabolic acidosis** and **ocular toxicity** observed. *Metabolic acidosis* - This statement is correct. Methanol poisoning leads to severe **anion gap metabolic acidosis** due to the accumulation of formic acid. - The acidosis contributes significantly to the overall toxicity and clinical manifestations. *Blindness* - This statement is correct. **Blindness** is a classic and feared complication of methanol poisoning. - **Formic acid** specifically targets the **optic nerve** and retina, leading to **optic neuropathy** and permanent vision loss. [Practice more Pharmacology PYQs on OnCourse]

Question

Which of the following statements about methyl alcohol poisoning is incorrect?

Accepted Answer

Fomepizole competitively inhibits aldehyde dehydrogenase

Answer

Effects are due to formic acid

Answer

Metabolic acidosis

Answer

Blindness

INI-CET 2013 — Pharmacology