Antimicrobials — Flashcards

Flashcard 551: What neurological side effect is associated with danazol?_____

Answer: Pseudotumor cerebri

Flashcard 552: In patients taking ruxolitinib, an important side effect is _____toxicity

Answer: hemato

Extra: Ruxolitinib is a JAK1/JAK2 inhibitor used in the treatment of myelofibrosis and polycythemia vera. Its primary dose-limiting side effects are **hematologic toxicities**, specifically **anemia** and **thrombocytopenia**. While mild LFT elevations can occur, "hematotoxicity" is the high-yield side effect for medical examinations.

Flashcard 553: PEGylated Liposomal Doxorubicin is useful for the treatment of _____

Answer: Kaposi Sarcoma

Flashcard 554: Paclitaxel (taxanes) inhibits mitotic spindle breakdown, which occurs in _____ of mitosis

Answer: anaphase*

Flashcard 555: Which drug is used instead of Rifampin in patients on HIV protease inhibitors?_____

Answer: Rifabutin

Flashcard 556: Anthracyclines (-rubicin) bind _____ to cause cleavage of DNA

Answer: topoisomerase II

Flashcard 557: Which of the platinum analogs is most commonly associated with myelosuppression?_____

Answer: Carboplatin

Flashcard 558: Myelosuppression due to methotrexate is reversible with _____

Answer: leucovorin

Flashcard 559: Procarbazine is a chemotherapeutic _____ agent used to treat hodgkin lymphoma and brain tumors

Answer: alkylating

Flashcard 560: Imatinib specifically inhibits the Bcr-Abl fusion protein by blocking the _____ portion

Answer: ATP-binding site of the Abl tyrosine kinase (Abl portion)