Antimicrobials — Flashcards

Flashcard 511: Neutropenia may result from drug toxicity, especially _____

Answer: chemotherapy

Flashcard 512: 6-mercaptopurine (and thus azathioprine) are degraded by the enzyme _____

Answer: xanthine oxidase

Flashcard 513: What is the most serious adverse effect associated with lamotrigine use?_____

Answer: Stevens-Johnson syndrome

Flashcard 514: Sulfasalazine is contraindicated in patients with an allergy to _____ drugs

Answer: sulfa

Extra: Sulfasalazine is a DMARD used in the treatment of rheumatoid arthritis and inflammatory bowel disease. It is a combination of sulfapyridine (a sulfonamide) and 5-aminosalicylic acid (5-ASA). It is contraindicated in patients with a sulfonamide (sulfa) allergy. Etanercept, while also used for RA, is a TNF-alpha inhibitor and does not have this contraindication.

Flashcard 515: Mycophenolate mofetil is a powerful inhibitor of _____ proliferation (cell type)

Answer: lymphocyte (B and T cell)

Flashcard 516: What toxic intermediate is formed in small amounts by metabolism of acetaminophen? _____

Answer: NAPQI

Flashcard 517: Cladribine is a DNA polymerase inhibitor that treats _____ leukemia

Answer: hairy cell

Flashcard 518: Fomepizole works as an antidote for methanol/ethylene glycol poisoning by inhibiting _____

Answer: Alcohol Dehydrogenase

Flashcard 519: Ipilimumab is a checkpoint inhibitor that binds to _____ on T cells.

Answer: CTLA-4

Flashcard 520: 5-fluorouracil can be used topically to treat _____

Answer: basal cell carcinoma