Antimicrobials — Flashcards

Flashcard 501: Eculizumab is a monoclonal antibody for the _____ complement protein

Answer: C5

Flashcard 502: Filgrastim is a recombinant form of _____

Answer: G-CSF

Flashcard 503: _____ inhibits the enzyme dihydroorotate dehydrogenase, which catalyzes the conversion of dihydroorotate to orotic acid (de novo pyrimidine synthesis).

Answer: Leflunomide

Flashcard 504: What is the treatment for overdose of drugs that act as weak acids (e.g. phenobarbital, methotrexate, aspirin)?_____

Answer: Bicarbonate (alkalinize urine)

Flashcard 505: What formula is used to calculate maintenance dose? _____

Answer: Maintenance dose = (Cp × CL × τ) / F

Extra: Cp = target plasma concentration at steady state CL = clearance τ = dosage interval F = bioavailability Note: Loading dose = (Cp × Vd) / F

Flashcard 506: Which antitumor monoclonal antibody is used to treat stage IV colorectal carcinoma (wild-type KRAS)?_____

Answer: Cetuximab

Flashcard 507: Rituximab binds CD20 of B-cells and tags it for natural killer cells via antibody-_____ cytotoxicity

Answer: dependent

Flashcard 508: Which antitumor monoclonal antibody targets HER2 (c-erbB2)?_____

Answer: trastuzumab (herceptin)

Flashcard 509: In _____ order kinetics, the rate of reaction is directly proportional to the substrate (drug) concentration

Answer: first

Flashcard 510: Phase _____ of clinical trials uses a large number of patients randomly assigned either to a treatment under investigation or the best available treatment (or placebo)

Answer: III