Antimicrobials — Flashcards

Flashcard 391: Because _____ induces CYP450 less than other drugs in its class (e.g., Rifampin), it is used in the treatment of tuberculosis in HIV patients

Answer: Rifabutin

Extra: Rifamycins (Rifampin, Rifabutin) inhibit DNA-dependent RNA polymerase. Rifabutin is specifically favored in HIV-infected patients receiving HAART to avoid significant reduction in antiretroviral drug levels.

Flashcard 392: Which **purine analog** antimetabolite (used in **Hairy Cell Leukemia**) can cause **neurotoxicity**?\n_____

Answer: Cladribine

Flashcard 393: Which chemotherapeutic drug is the most widely-used treatment of colorectal cancer? _____

Answer: 5-fluorouracil

Extra:   Watch Methotrexate, leucovorin, 5 fluorouracil, hydroxyurea [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antineoplastics/videos/medical-pharmacology-antineoplastics-antimetabolites-methotrexate-leucovorin-5-fluorouracil-hydroxyurea?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-structure?index=10] https://onlinemeded.org?ref=anki  Surgical techniques in colorectal cancer 1) Right hemicolectomy 2) Left hemicolectomy 3) Extended right hemicolectomy 4) Sigmoid colectomy (right dot = arc of Riolan) 

Flashcard 394: Can Allopurinol cause sloughing of skin at the dermal-epidermal junction? _____

Answer: Yes

Extra:   Watch Gout drugs [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-blood-inflammation/videos/medical-pharmacology-blood-and-inflammation-anti-inflammatory-gout-drugs?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-structure?index=6] https://onlinemeded.org/spa/musculoskeletal?ref=anki 

Flashcard 395: Panobinostat is used to treat _____ that is refractory to bortezomib + dexamethasone

Answer: multiple myeloma

Extra: #REF! https://onlinemeded.org?ref=anki 

Flashcard 396: _____ can be used to treat Leishmaniasis

Answer: Sodium stibogluconate

Extra:  https://onlinemeded.org/spa/microbiology/protozoa/acquire?ref=anki 

Flashcard 397: What type of vaccine is the acellular pertussis (aP) vaccine? _____

Answer: Subunit

Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/immunology/videos/vaccinations?index=8] https://onlinemeded.org/spa/pediatrics/vaccinations/acquire?ref=anki 

Flashcard 398: Alcohols and Chlorhexidine work by _____ proteins and disrupting cell membranes

Answer: denaturing

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 399: What serious adverse effect may be caused by vigabatrin use? _____

Answer: Permanent vision loss (black box warning)

Extra:  First Aid Pharmacology: Neuro/Psych  https://onlinemeded.org?ref=anki 

Flashcard 400: Choriocarcinomas and Trophoblastic Tumors can be treated with _____

Answer: Methotrexate

Extra:   * especially if dilation and curettage does not work and levels of β-hCG persist  https://onlinemeded.org?ref=anki