Antimicrobials — Flashcards

Flashcard 241: Anions such as _____, pertechnetate, and thiocyanate competively inhibit the sodium-iodide transporter

Answer: perchlorate

Extra:   Watch Propylthiouracil, methimazole, levothyroxine [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-gi-endocrine/videos/medical-pharmacology-gi-and-endocrine-thyroid-parathyroid-and-adrenal-propylthiouracil-methimazole-levothyroxine?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/endocrine?ref=anki 

Flashcard 242: Pyrimethamine + Sulfadiazine is the 1st line treatment for _____

Answer: Toxoplasmosis

Flashcard 243: Esophagitis may occur with medications such as _____, tetracyclines, NSAIDs, iron, and potassium chloride

Answer: bisphosphonates

Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/esophageal-and-gastric-pathology?index=2] https://onlinemeded.org/spa/gastroenterology/esophagus/acquire?ref=anki 

Flashcard 244: Actinomycin D (aka Dactinomycin) is an antineoplastic antibiotic that works by preventing _____ through the process of DNA intercalation

Answer: transcription

Extra:    https://onlinemeded.org?ref=anki 

Flashcard 245: Cladribine is activated primarily in _____ and is resistant to degradation by adenosine deaminase (ADA).

Answer: lymphocytes

Extra: Cladribine is a purine analog that is phosphorylated to its active form by deoxycytidine kinase. Unlike adenosine, it is resistant to degradation by adenosine deaminase (ADA), leading to high intracellular concentrations and toxicity in lymphocytes. Note: Pentostatin is the drug that actually inhibits ADA.

Flashcard 246: Lung cancers with a EML4-ALK fusion protein are typically EGFR _____ / KRAS _____ *bonus: treat with..?

Answer: negative

Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pulmonology/videos/lung-cancer?index=6] https://onlinemeded.org/spa/pulmonology/lung-cancer/acquire?ref=anki 

Flashcard 247: What class of antimicrobials are the following drugs? - Azithromycin - Clarithromycin - Erythromycin _____

Answer: Macrolides

Extra: Macrolides typically end in the suffix **-thromycin**. Note that Fidaxomicin is a unique macrolide used for *C. difficile*.

Flashcard 248: Etoposide and teniposide can result in _____-suppression and _____-suppression

Answer: myelo

Extra:   Watch Etoposide, teniposide, topotecan, irinotecan [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antineoplastics/videos/medical-pharmacology-antineoplastics-dna-and-cellular-division-etoposide-teniposide-topotecan-irinotecan?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org?ref=anki 

Flashcard 249: What drugs are characterized by binding to an ulcer base and providing physical protection? _____

Answer: Bismuth, sucralfate

Extra:  First Aid Pharmacology: GI (Antacids)  https://onlinemeded.org/spa/gastrointestinal?ref=anki  

Flashcard 250: _____ inhibits the enzyme dihydroorotate dehydrogenase, which catalyzes the conversion of dihydroorotate to orotic acid (pyrimidine synthesis).

Answer: Leflunomide