Cell injury — Flashcards

Flashcard 231: Which cells release proteolytic enzymes in response to brain abscess, causing liquefactive necrosis?_____

Answer: Neutrophils

Flashcard 232: What is the standard screening test for G6PD deficiency?

Answer: Fluorescent spot test

Extra: The methemoglobin reduction test is another screening option. Heinz bodies (denatured hemoglobin) are visualized using supravital stains like crystal violet during an acute hemolytic episode. The definitive/confirmatory test is a quantitative G6PD enzyme assay.

Flashcard 233: In β-thalassemia major, __________ tetramers precipitate and damage RBCs.

Answer: α-globin (alpha-4) tetramers

Flashcard 234: What type of red blood cell is associated with microangiopathic hemolytic anemia? _____

Answer: Schistocytes ("helmet cells")

Flashcard 235: The morphologic hallmark of cell death is loss of the _____

Answer: nucleus

Flashcard 236: _____ membrane damage in irreversible cell injury results in hydrolytic enzymes leaking into the cytosol

Answer: Lysosome

Flashcard 237: Which virus/viral family will have cytoplasmic, eosinophilic inclusions within neuronal cells?_____

Answer: Rabies virus (Rhabdoviridae); Negri bodies

Flashcard 238: Which type of calcification (dystrophic or metastatic) tends to be localized? _____

Answer: Dystrophic

Flashcard 239: _____ is caused by infarction of bone and marrow

Answer: Osteonecrosis (avascular necrosis)

Flashcard 240: Which cellular change is characterized by a decrease in tissue mass due to decrease in size or number of cells? _____

Answer: Atrophy