Fat necrosis of breast tissue presents as a painless _____ on physical exam
Niemann Pick disease may present with progressive _____
Which layer of the cerebellum is most affected by global cerebral ischemia? _____
Ionizing radiation results in the formation of double-stranded breaks in DNA and _____ which damage DNA
Photoaging results in gradual _____ of the epidermis, allowing the stratum corneum to become dessicated
Defects in the ubiquitin-proteasome system have been implicated in some cases of _____ disease
_____ necrosis is characteristic of chronic ischemia of the lower limb and GI tract
Are patients with metastatic calcifications usually normocalcemic? _____
Deposits of lipofuscin are commonly found in the _____, heart, colon, kidney, and eye of elderly individuals; and are caused by lipid peroxidation
1. Disaggregation of polysomes (dissociation of rRNA from mRNA) 2. Myofibril relaxation 3. Disaggregation of nuclear granules & clumping of nuclear chromatin 4. Triglyceride droplet accumulation 5. Glycogen loss The above changes are signs of _____ myocyte injury
Hint: reversible/irreversible
Reversible cell injury mechanisms
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Irreversible cell injury (necrosis)
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Types of necrosis (coagulative, liquefactive, etc.)
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Apoptosis pathways
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Autophagy mechanisms
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Cellular adaptations (atrophy, hypertrophy)
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Hyperplasia and metaplasia
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Dysplasia
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Intracellular accumulations
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Pathologic calcification
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Cellular aging mechanisms
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Ischemia-reperfusion injury
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Free radical injury
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These Cell injury flashcards are designed for USMLE Pathology preparation, using active recall to help you retain high-yield concepts, clinical correlations, and commonly tested facts. Each card prompts you to retrieve information from memory rather than passively reviewing notes, which research shows leads to significantly better exam performance.
The 273 cards in this deck cover the most important topics in Cell injury, including key mechanisms, diagnostic criteria, treatment protocols, and clinical pearls that frequently appear in USMLE examinations. Cards are organised by chapter so you can focus on specific areas or work through the entire topic systematically.
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