Endocrine Pharmacology — Flashcards

Flashcard 11: MOA of centchroman is _____

Answer: SERM

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Flashcard 12: mc side effect of OC pills is _____

Answer: weight gain

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Flashcard 13: Centchroman is _____

Answer: a non hormonal oral contraceptive

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Flashcard 14: First Aid Pharmacology: Endocrine _____ is a recombinant form of PTH used to treat osteoporosis

Answer: Teriparatide

Flashcard 15: _____ is an oral 11-hydroxylase inhibitor for adults with Cushings disease who either cannot undergo pituitary gland surgery or have undergone the surgery but still have the disease.

Answer: Osilodrostat

Flashcard 16: Ketoconazole and spironolactone both inhibit _____, while ketoconazole additionally inhibits cholesterol desmolase.

Answer: 17α-hydroxylase

Extra: Both drugs also inhibit 17,20-lyase. Inhibition of these enzymes (17α-hydroxylase and 17,20-lyase) contributes to their anti-androgenic effects. Ketoconazole's inhibition of cholesterol desmolase (side-chain cleavage enzyme) blocks the very first step of steroidogenesis, leading to a broad reduction in all adrenal and gonadal steroids.

Flashcard 17: _____ may be used in the treatment of primary or secondary hyperparathyroidism by increasing the sensitivity of calcium-sensing receptors to extracellular calcium.

Answer: Cinacalcet

Flashcard 18: Treatment for Paget disease of bone includes _____ and bisphosphonates

Answer: calcitonin

Flashcard 19: Thyroid, Pituitary, & Adrenal _____ and bromocriptine are D2 receptor agonists, which may be used to treat acromegaly by inhibiting secretion of GH from the anterior pituitary

Answer: Cabergoline

Flashcard 20: _____ is a nonsteroidal contraceptive taken twice weekly as a 30mg tablet for 12 weeks and weekly thereafter

Answer: Ormeloxifene