Hematopathology — Flashcards

Flashcard 81: Impaired division of granulocytic precursors in _____ anemia leads to hypersegmented neutrophils

Answer: megaloblastic

Flashcard 82: _____ leukemia is associated with smudge cells and increased lymphocytes on blood smear

Answer: Chronic lymphocytic

Flashcard 83: _____ is due to inhibition or deficiency of the ADAMTS13 (vWF metalloprotease) enzyme

Answer: Thrombotic thrombocytopenic purpura (TTP)

Flashcard 84: EBV-positive diffuse large-cell lymphoma is _____ for CD20, CD79a, IRF4/MUM1, LMP1 and CD15 negative

Answer: positive

Flashcard 85: DIC typically presents with increased _____ split products, particularly D-dimer

Answer: fibrin

Flashcard 86: _____ is prolonged in all platelet disorders (both quantitative and qualitative)

Answer: Bleeding time

Flashcard 87: Diagnostic criteria for CMML includes persistent peripheral blood monocytosis ≥ _____ x 10⁹/L, with monocytes accounting for ≥ 10% of the WBC count.

Answer: 1

Extra: WHO Diagnostic Criteria for CMML: 1. Persistent peripheral blood monocytosis ≥ 1 x 10⁹/L. 2. Monocytes account for ≥ 10% of the WBC count. 3. Blast count in blood and bone marrow is < 20%. 4. Not meeting WHO criteria for BCR-ABL1+ CML, PV, ET, or PMF. 5. No rearrangement of PDGFRA, PDGFRB, FGFR1, or PCM1-JAK2.

Flashcard 88: The bone lesions seen with multiple myeloma are most common in the _____ and skull

Answer: vertebrae

Flashcard 89: Disorders of primary hemostasis are divided into _____ and quantitative disorders

Answer: qualitative

Flashcard 90: β-thalassemia mutations in β-globin genes result in _____ or diminished (β+) production of the β-globin chain

Answer: absent (β0)