Hematopathology — Flashcards

Flashcard 411: College-girl or Garden party appearance in peripheral blood smear is described for _____ leukemia

Answer: chronic myeloid

Flashcard 412: Which blood products have a high chance of bacterial contamination?_____

Answer: Platelets

Flashcard 413: On bone marrow biopsy, hairy cell leukemia will show a _____ appearance of leukemic cells

Answer: fried egg

Flashcard 414: The best investigation to diagnose marrow aplasia is bone marrow _____

Answer: biopsy

Flashcard 415: What is the investigation of choice for diagnosing myelofibrosis?_____

Answer: Bone marrow biopsy

Flashcard 416: Glucose 6 phosphate dehydrogenase (G6PD) deficiency leads to _____ hemolysis

Answer: both extravascular and intravascular

Flashcard 417: Tumor cells with multilobulated nuclei ( cloverleaf or flower cells) is characteristic of _____

Answer: Adult T-Cell Leukemia/Lymphoma

Flashcard 418: Sickle cells have _____ mechanical fragility and _____ osmotic fragility.

Answer: high; low

Flashcard 419: G6PD deficiency has _____ red cells.

Answer: Bite cells (degmacytes) and Blister cells

Extra: Oxidative stress in G6PD deficiency leads to the oxidation of hemoglobin into Heinz bodies. As these cells pass through the splenic sinusoids, splenic macrophages 'bite' out the Heinz bodies, resulting in Bite cells (degmacytes). Blister cells are also seen where the hemoglobin has contracted away from the cell membrane.

Flashcard 420: _____ syndrome is the transformation of _____ to aggressive lymphoma

Answer: Richter's; chronic lymphocytic leukemia (CLL)