Hematopathology — Flashcards

Flashcard 391: Which variant of large-cell non-Hodgkin lymphomas is associated with Reed-Sternberg cells?_____

Answer: immunoblastic NHL

Flashcard 392: Marrow biopsy of patients with _____ leukemia may show macrophages engulfing the apoptotic tumor cells, giving it a "starry sky" appearance.

Answer: Burkitt leukemia (Acute Lymphoblastic Leukemia, FAB L3 subtype)

Flashcard 393: Which non-hodgkin's lymphoma presents most commonly as a destructive nasopharyngeal mass?_____

Answer: Extranodal NK/T-Cell Lymphoma

Flashcard 394: What AML subtype is associated with CD41/61?_____

Answer: AML M7 (megakaryocytic)

Flashcard 395: Against which RBC antigen are the IgM antibodies of cold agglutination reaction directed?_____

Answer: I/i antigen

Flashcard 396: Lowest number of Reed-Sternberg cells is seen in the _____ variant of Hodgkin lymphoma

Answer: Lymphocyte predominant

Flashcard 397: Hemoglobin level associated with poor prognosis in Hodgkin Lymphoma (International Prognostic Score criteria)

Answer: < 10.5 g/dL

Extra: The International Prognostic Score (IPS) for Advanced Hodgkin Lymphoma (Hasenclever index) includes 7 factors: 1. Albumin < 4 g/dL 2. **Hemoglobin < 10.5 g/dL** 3. Male sex 4. Age ≥ 45 years 5. Stage IV disease 6. Leukocytosis (WBC ≥ 15,000/mm³) 7. Lymphocytopenia (< 600/mm³ or < 8% of differential)

Flashcard 398: The estimation of prothrombin time (PT) and activated Partial Thromboplastin Time (aPTT) requires platelet-_____ plasma

Answer: poor

Flashcard 399: Lysozymes and alkaline phosphatase are a part of _____ granules of neutrophils.

Answer: secondary (specific)

Flashcard 400: For testing PTT, the sample is activated by using _____

Answer: kaolin/silica/ellagic acid