Hematopathology — Flashcards

Flashcard 311: Blasts usually make up less than _____% of the circulating cells in chronic phase of chronic myeloid leukemia

Answer: 5

Flashcard 312: The most common cytogenetic abnormality associated with lymphoplasmacytic lymphoma is deletion of _____

Answer: 6q

Flashcard 313: Are Bence Jones proteins seen in urine in monoclonal gammopathy of undetermined significance (MGUS)?

Answer: No (or characteristically absent)

Extra: MGUS is defined by: 1. Serum M-protein < 3 g/dL 2. Bone marrow plasma cells < 10% 3. No CRAB symptoms (end-organ damage) 4. **No significant Bence Jones proteinuria** (< 500 mg/24h) Bence Jones proteins (monoclonal free light chains) in the urine are a hallmark of Multiple Myeloma.

Flashcard 314: _____ disease is sinus histiocytosis with massive lymphadenopathy

Answer: Rosai Dorfman

Flashcard 315: What AML subtype is associated with chloromas?_____

Answer: AML M2, M5a, M5b, M4

Flashcard 316: Normal karyotyping with mutated NPM1 suggests a _____ prognosis for AML

Answer: good

Flashcard 317: The lower blasts cutoff percentage for diagnosing acute lymphoblastic leukemia (ALL) on bone marrow biopsy is _____%.

Answer: 20% (WHO criteria)

Flashcard 318: Is Ph chromosome seen in JMML?_____

Answer: No

Flashcard 319: Which immunohistochemical marker is associated with cyclin D1 negative mantle cell lymphoma?_____

Answer: SOX11

Flashcard 320: _____ is the most specific and sensitive marker for Hairy-cell leukemia

Answer: Annexin A1