Hematopathology — Flashcards

Flashcard 231: Large granular lymphocytic leukemia will have mutations in the _____ gene

Answer: STAT3

Flashcard 232: What is the most common tumor arising due to ionizing radiation (medical imaging)?_____

Answer: Myeloid leukemia

Flashcard 233: Hemophagocytic lymphohistiocytosis is characterized by low or absent _____ cell activity

Answer: NK

Flashcard 234: HAM S test (acidified serum lysis) is used for the diagnosis of _____

Answer: Paroxysmal nocturnal hemoglobinuria

Flashcard 235: In Small Lymphocytic Lymphoma (SLL), the absolute lymphocyte count is < _____ per mm³.

Answer: 5,000 (If ≥ 5,000, it is classified as CLL)

Extra: Small Lymphocytic Lymphoma (SLL) and Chronic Lymphocytic Leukemia (CLL) are biologically the same disease. The distinction is based on where the bulk of the disease is located and the peripheral blood count: - **SLL:** Lymphadenopathy + Absolute Lymphocyte Count (ALC) < 5,000/mm³ - **CLL:** ALC ≥ 5,000/mm³ (regardless of lymph node involvement)

Flashcard 236: Which subtype of MGUS can progress to Waldenström macroglobulinemia?

Answer: IgM MGUS

Flashcard 237: _____ is a marker for Waldenström macroglobulinemia

Answer: MYD88

Flashcard 238: _____ protein deficiency is responsible for the mushroom cell shape of the RBCs

Answer: Band 3

Flashcard 239: Anaplastic large cell lymphoma is a _____-cell lymphoma with large lymphoid cells

Answer: T

Flashcard 240: _____ is an aggressive lymphoid neoplasm that classically occurs in the oral cavity in immunosuppressed patients

Answer: Plasmablastic lymphoma