Hematopathology Indian Medical PG Flashcards - Medical Study Cards
Master Hematopathology with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Hematopathology Flashcard Deck - 10 Cards
Flashcard 211: _____ -thalassemia is usually due to gene deletions
Answer: Alpha
Flashcard 212: Marginal zone lymphoma (MALT type) can harbour _____, t(1;14), or t(14;18) translocations that render their growth and survival antigen-independent.
Answer: t(11;18)
Extra: These translocations lead to constitutive activation of the **NF-κB** pathway, bypassing the need for chronic antigen stimulation (e.g., *H. pylori*):
- **t(11;18)(q21;q21)**: *BIRC3-MALT1* (formerly *API2-MALT1*) — most common.
- **t(1;14)(p22;q32)**: *BCL10-IGH*.
- **t(14;18)(q32;q21)**: *IGH-MALT1* (Distinct from the t(14;18) in follicular lymphoma which involves *BCL2*).
Flashcard 213: In atypical chronic myeloid leukemia (aCML), monocytes typically constitute what percentage of the white blood cell count?
Answer: < 10%
Extra: Atypical chronic myeloid leukemia (BCR-ABL1 negative) is a myelodysplastic/myeloproliferative neoplasm (MDS/MPN) characterized by leukocytosis and prominent granulocytic dysplasia. One of the diagnostic criteria to distinguish aCML from CMML is that monocytes must constitute < 10% of the total white blood cell count.
Flashcard 214: Which white blood cells can be elevated in patients of polycythemia vera?_____
Answer: Basophils and eosinophils
Flashcard 215: DCIP test is a test-tube turbidity test used for the screening of hemoglobin _____
Answer: E
Flashcard 216: Which AML subtype is also known as Schilling type?_____
Answer: AML M5 (monocytic or monoblastic)
Flashcard 217: Hermansky-Pudlak syndrome is a disorder involving platelet _____ granules
Answer: Dense (delta) granules
Flashcard 218: Cryoprecipitate is stored at a temperature of _____ °C
Answer: -18°C or colder (commonly -30°C)
Extra: Cryoprecipitate is prepared by thawing Fresh Frozen Plasma (FFP) at 4°C and collecting the precipitate.
Storage:
- Frozen: -18°C or colder for up to 1 year.
- Thawed: 20–24°C (room temperature); must be transfused within 6 hours (or 4 hours if pooled in an open system). Do NOT refrigerate after thawing as it causes reprecipitation of clotting factors.
Contents: Fibrinogen, Factor VIII, Factor XIII, von Willebrand factor (vWF), and Fibronectin.
Flashcard 219: _____ is a unique subtype of MGUS in which there is no immunoglobulin heavy-chain component
Answer: LC-MGUS
Flashcard 220: What is the most common subtype of MGUS?_____
Answer: Non-IgM MGUS
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