Hematopathology — Flashcards

Flashcard 141: Hereditary spherocytosis most commonly involves defects in _____, spectrin, band 3, or protein 4.2

Answer: ankyrin

Flashcard 142: _____ anemia is associated with ringed sideroblasts, in which iron-laden mitochondria form a ring around the nucleus of erythroid precursors

Answer: Sideroblastic

Flashcard 143: _____ T-cells (ballerina skirt cells) are atypical CD8+ cytotoxic T-cells seen on a blood smear of Epstein-Barr Virus

Answer: Downey type II

Flashcard 144: _____ -blasts are usually characterized by positive cytoplasmic staining for myeloperoxidase (MPO)

Answer: Myelo

Flashcard 145: Disorders of fibrinolysis typically present with _____ PT and increased PTT

Answer: increased

Flashcard 146: Lymphoma is divided into _____ (~85%) and Hodgkin lymphoma (~15%) *bonus: age groups

Answer: non-Hodgkin

Extra: Age groups: - Hodgkin Lymphoma: Bimodal distribution (peaks in young adults ~20s and elderly ~50s+). - Non-Hodgkin Lymphoma: Generally occurs in older adults (incidence increases with age).

Flashcard 147: Normocytic anemia with _____-vascular hemolysis may cause leakage of hemoglobin into the blood and urine

Answer: intra

Flashcard 148: RBCs stored in _____ can be kept until 21 days

Answer: ACD

Flashcard 149: _____ is characterized by Birbeck (tennis racket) granules on electron microscopy

Answer: Langerhans cell histiocytosis

Flashcard 150: Endotoxin/Lipopolysaccharide of Gram Negative Bacteria can activate _____, resulting in coagulation and possible DIC (disseminated intravascular coagulation)

Answer: tissue factor