Hematopathology — Flashcards

Flashcard 91: Lymphomas are malignancies of _____ leukocytes, whereas Leukemias are malignancies of immature leukocytes

Answer: mature

Flashcard 92: _____ lymphoma is a neoplastic proliferation of Reed-Sternberg cells

Answer: Hodgkin

Flashcard 93: The bone lesions seen with multiple myeloma are most common in the _____ and skull

Answer: vertebrae

Flashcard 94: DIC typically presents with increased _____ split products, particularly D-dimer

Answer: fibrin

Flashcard 95: β-thalassemia mutations in β-globin genes result in _____ or diminished (β+) production of the β-globin chain

Answer: absent (β0)

Flashcard 96: Normocytic anemia with _____-vascular hemolysis is associated with enlargement of the spleen (splenomegaly)

Answer: extra

Flashcard 97: _____ lymphoma is a neoplastic proliferation of small B cells (CD20+ & CD5+) that expands into the mantle zone

Answer: Mantle cell

Flashcard 98: Diagnostic criteria for CMML includes persistent peripheral blood monocytosis ≥ _____ x 10⁹/L, with monocytes accounting for ≥ 10% of the WBC count.

Answer: 1

Extra: WHO Diagnostic Criteria for CMML: 1. Persistent peripheral blood monocytosis ≥ 1 x 10⁹/L. 2. Monocytes account for ≥ 10% of the WBC count. 3. Blast count in blood and bone marrow is < 20%. 4. Not meeting WHO criteria for BCR-ABL1+ CML, PV, ET, or PMF. 5. No rearrangement of PDGFRA, PDGFRB, FGFR1, or PCM1-JAK2.

Flashcard 99: Megaloblastic anemia occurs due to delayed maturation of the _____ relative to the cytoplasm of precursor RBCs

Answer: nucleus

Flashcard 100: In lymph nodes, _____ follicles have pale, central germinal centers and are active

Answer: secondary