Hemoglobin and Iron Metabolism — Flashcards

_____ iron (vegetable-derived) must be converted to Fe2+ in the duodenum / proximal jejunum by cytochrome B and/or Vitamin C for absorption

In _____ porphyria, the teeth have a reddish discoloration, due to accumulation of Uroporphyrin I or Coproporphyrin I

Porphobilinogen is converted to _____ via the enzyme porphobilinogen deaminase (heme synthesis)

Delta-aminolevulinic acid synthase is regulated via negative feedback by _____ and heme

The two embryonic globins are _____ and epsilon (ε)

_____ is a measure of transferrin molecules in the blood

_____ iron (meat-derived) is readily absorbed and enters the duodenal cell via the heme transporter

The _____ form of hemoglobin has a high affinity for O2

Primary _____ is due to mutations in the HFE gene on chromosome 6, leading to increased expression of DMT1 and decreased synthesis of Hepcidin

_____ and Fe2+ combine to form heme via the enzyme ferrochelatase