Hemoglobin and Iron Metabolism — Flashcards

Hb _____ results from globin chain mutations that stabilize iron in the ferric state, leading to congenital methemoglobinemia.

The increased O2 binding affinity of fetal hemoglobin results from _____ affinity of HbF for 2,3-BPG

Iron deficiency anemia is associated with a(n) _____ free erythrocyte protoporphyrin (FEP)

There are _____ total beta-globin alleles present on chromosome 11

Endothelial cells prevent thrombosis by secreting _____ molecules, which augment antithrombin III (ATIII)

Hemoglobin C disease occurs due to a point mutation that substitutes _____ with lysine

_____ seen with carbon monoxide poisoning is due to binding of CO to myoglobin

_____ is an iron-dependent pathway of cell death induced by lipid peroxidation.

Hemoglobin exists in two forms: _____ (deoxygenated) and relaxed (oxygenated)

In _____, urine urobilinogen is increased, while urine bilirubin is absent.