Free notes, MCQs, tables & flowcharts for NEET-PG Internal Medicine
Which of the following statements is true regarding competitive reversible antagonism?
AED50 remains unchanged in competitive reversible antagonism.
BEfficacy and Vmax remain unchanged.
CPotency remains unchanged in the presence of a competitive antagonist.
DAffinity (Kd) remains unchanged in competitive reversible antagonism.
Volume of distribution of a drug is 500 ml and target concentration of drug in blood is 5 g/L. 20% of administered drug is reached to systemic circulation. What will be the loading dose of that drug -
A1 gm
B5 gm
C25 gm
D12.5 gm
A patient named Ram Prasad is admitted to Guru Teg Bahadur Hospital with a respiratory infection. Tobramycin is ordered for treatment. Given that the clearance and volume of distribution of tobramycin in him are 160 mL/min and 40 L, respectively, calculate the intravenous loading dose required to achieve a therapeutic plasma concentration of 4 mg/L.
A0.1 mg
B10 mg
C115.2 mg
D160 mg
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