Autonomic/CV Drugs — MCQs

A 73-year-old woman recently diagnosed with colonic adenocarcinoma comes to the physician because of a 1-week history of nausea and multiple episodes of vomiting. These symptoms started shortly after her first infusion of oxaliplatin and fluorouracil. The patient is started on an appropriate medication. Three weeks later, at a follow-up appointment, she states that she has developed headaches and constipation. The patient was most likely treated with a drug with which of the following mechanisms of action?

Two hours after undergoing elective cholecystectomy with general anesthesia, a 41-year-old woman is evaluated for decreased mental status. BMI is 36.6 kg/m2. Respirations are 18/min and blood pressure is 126/73 mm Hg. Physical examination shows the endotracheal tube in normal position. She does not respond to sternal rub and gag reflex is absent. Arterial blood gas analysis on room air shows normal PO2 and PCO2 levels. Which of the following anesthetic properties is the most likely cause of these findings?

A 56-year-old man with type 2 diabetes mellitus comes to the physician for a follow-up examination. Three months ago, the patient was started on metformin therapy after counseling on diet, exercise, and weight reduction failed to reduce his hyperglycemia. Physical examination shows no abnormalities. His hemoglobin A1c is 8.4%. Pioglitazone is added to the patient's medication regimen. Which of the following cellular changes is most likely to occur in response to this new drug?

A 19-year-old male college student is brought to the emergency department by his girlfriend complaining of intense pain. They had been playing outside in the snow when the patient started to have severe hand and feet pain. He says the pain is 9 out of 10 and causing him to have trouble moving his fingers and toes. He also reports some difficulty “catching his breath.” He notes that he has been tiring easily for the past month but thought it was because he was studying and going out late. On physical examination, the patient appears uncomfortable. Bilateral conjunctivae are pale. His hands are swollen and tender to palpation. Cardiopulmonary examination is normal. Hemoglobin is 9.0 g/dL. An electrocardiogram shows mild sinus tachycardia. Hemoglobin electrophoresis is performed, which confirms sickle cell disease. The patient’s pain is managed, and he is discharged on hydroxyurea. Which of the following is the most likely to occur as a result of the new medication?

A 38-year-old male is brought to the emergency department by ambulance after a motor vehicle collision. He is found to have a broken femur and multiple soft tissue injuries and is admitted to the hospital. During the hospital course, he is found to have lower extremity swelling, redness, and pain, so he is given an infusion of a medication. The intravenous medication is discontinued in favor of an oral medication in preparation for discharge; however, the patient leaves against medical advice prior to receiving the full set of instructions. The next day, the patient is found to have black lesions on his trunk and his leg. The protein involved in this patient's underlying abnormality most likely affects the function of which of the following factors?

A 61-year-old woman comes to the physician because of a 6-month history of left knee pain and stiffness. Examination of the left knee shows tenderness to palpation along the joint line; there is crepitus with full flexion and extension. An x-ray of the knee shows osteophytes with joint-space narrowing. Arthrocentesis of the knee joint yields clear fluid with a leukocyte count of 120/mm3. Treatment with ibuprofen during the next week significantly improves her condition. The beneficial effect of this drug is most likely due to inhibition of which of the following?

A 31-year-old female receives a kidney transplant for autosomal dominant polycystic kidney disease (ADPKD). Three weeks later, the patient experiences acute, T-cell mediated rejection of the allograft and is given sirolimus. Which of the following are side effects of this medication?

A 29-year-old woman presents to the primary care office for a recent history of falls. She has fallen 5 times over the last year. These falls are not associated with any preceding symptoms; she specifically denies dizziness, lightheadedness, or visual changes. However, she has started noticing that both of her legs feel weak. She's also noticed that her carpet feels strange beneath her bare feet. Her mother and grandmother have a history of similar problems. On physical exam, she has notable leg and foot muscular atrophy and 4/5 strength throughout her bilateral lower extremities. Sensation to light touch and pinprick is decreased up to the mid-calf. Ankle jerk reflex is absent bilaterally. Which of the following is the next best diagnostic test for this patient?

A 17-year-old male with a history of bipolar disorder presents to clinic with a rash (Image A) that he noticed one week after starting a medication to stabilize his mood. The medication blocks voltage-gated sodium channels and can be used to treat partial simple, partial complex, and generalized tonic-clonic seizures. Regarding the patient's rash, what is the next step in management?

A 3-year-old boy is brought in by his parents to the emergency department for lethargy and vomiting. The patient was fine until this afternoon, when his parents found him in the garage with an unlabeled open bottle containing an odorless liquid. On exam, the patient is not alert or oriented, but is responsive to touch and pain. The patient is afebrile and pulse is 90/min, blood pressure is 100/60 mmHg, and respirations are 20/min. Which of the following is an antidote for the most likely cause of this patient’s presentation?