Antimicrobials — MCQs

A 62-year-old man comes to the physician because of a 5-day history of fatigue, fever, and chills. For the past 9 months, he has had hand pain and stiffness that has progressively worsened. He started a new medication for these symptoms 3 months ago. Medications used prior to that included ibuprofen, prednisone, and hydroxychloroquine. He does not smoke or drink alcohol. Examination shows a subcutaneous nodule at his left elbow, old joint destruction with boutonniere deformity, and no active joint warmth or tenderness. The remainder of the physical examination shows no abnormalities. His hemoglobin concentration is 10.5 g/dL, leukocyte count is 3500/mm3, and platelet count is 100,000/mm3. Which of the following is most likely to have prevented this patient's laboratory abnormalities?

A patient with HCC and a long history of alcohol dependence and chronic hepatitis C has been using the mTOR inhibitor sirolimus 100 mg for cancer treatment. Her cancer has shown a partial response. She also has a history of hypertension and poorly controlled type 2 diabetes mellitus complicated by diabetic retinopathy. Current medications include enalapril and insulin. She asks her oncologist and hepatologist if she could try everolimus for its purported survival benefit in treating HCC. Based on clinical considerations, which of the following statements is most accurate?

A general surgery intern is paged to the bedside of a 59-year-old male who underwent a successful sigmoidectomy for treatment of recurrent diverticulitis. The patient's nurse just recorded a temperature of 38.7 C, and relates that the patient is complaining of chills. The surgery was completed 8 hours ago and was complicated by extensive bleeding, with an estimated blood loss of 1,700 mL. Post-operative anemia was diagnosed after a hemoglobin of 5.9 g/dL was found; 2 units of packed red blood cells were ordered, and the transfusion was initiated 90 minutes ago. The patient's vital signs are as follows: T 38.7 C, HR 88, BP 138/77, RR 18, SpO2 98%. Physical examination does not show any abnormalities. After immediately stopping the transfusion, which of the following is the best management of this patient's condition?

You are seeing a patient in clinic who recently started treatment for active tuberculosis. The patient is currently being treated with rifampin, isoniazid, pyrazinamide, and ethambutol. The patient is not used to taking medicines and is very concerned about side effects. Specifically regarding the carbohydrate polymerization inhibiting medication, which of the following is a known side effect?

A 27-year-old man presents to his primary care physician for his first appointment. He recently was released from prison. The patient wants a checkup before he goes out and finds a job. He states that lately he has felt very fatigued and has had a cough. He has lost roughly 15 pounds over the past 3 weeks. He attributes this to intravenous drug use in prison. His temperature is 99.5°F (37.5°C), blood pressure is 127/68 mmHg, pulse is 100/min, respirations are 18/min, and oxygen saturation is 98% on room air. The patient is started on appropriate treatment. Which of the following is the most likely indication to discontinue this patient's treatment?

A 52-year-old farmer presents to his physician with a puncture wound on his left shin. He got this wound accidentally when he felt unwell and went out to his garden "to catch some air". He reports he had been treated for tetanus 35 years ago and has received the Tdap vaccine several times since then, but he does not remember when he last received the vaccine. His vital signs are as follows: the blood pressure is 110/80 mm Hg, heart rate is 91/min, respiratory rate is 19/min, and temperature is 37.8°C (100.0°F). On physical examination, he is mildly dyspneic and pale. Lung auscultation reveals diminished vesicular breath sounds in the lower lobes bilaterally with a few inspiratory crackles heard over the left lower lobe. There is a puncture wound 1 cm in diameter that is contaminated with soil in the middle third of the patient’s shin. You order blood tests and an X-ray, and now you are arranging his wound treatment. How should tetanus post-exposure prevention be performed in this case?

Nucleic acid amplification testing (NAAT) of first-void urine confirms infection with Chlamydia trachomatis. Treatment with the appropriate pharmacotherapy is started. Which of the following health maintenance recommendations is most appropriate at this time?

A 5-year-old boy presents with altered mental status and difficulty breathing for the past couple of hours. The patient’s father, a mechanic, says the boy accidentally ingested an unknown amount of radiator fluid. The patient’s vital signs are: temperature 37.1°C (98.8.F), pulse 116/min, blood pressure 98/78 mm Hg, and respiratory rate 42/min. On physical examination, cardiopulmonary auscultation reveals deep, rapid respirations with no wheezing, rhonchi, or crepitations. An ABG reveals the blood pH to be 7.2 with an anion gap of 16 mEq/L. Urinalysis reveals the presence of oxalate crystals. Which of the following is the most appropriate antidote for the poison that this patient has ingested?

Three days after starting a new drug for malaria prophylaxis, a 19-year-old college student comes to the physician because of dark-colored urine and fatigue. He has not had any fever, dysuria, or abdominal pain. He has no history of serious illness. Physical examination shows scleral icterus. Laboratory studies show a hemoglobin of 9.7 g/dL and serum lactate dehydrogenase of 234 U/L. Peripheral blood smear shows poikilocytes with bite-shaped irregularities. Which of the following drugs has the patient most likely been taking?

A 67-year-old woman with advanced bladder cancer comes to the physician for a follow-up examination. She is currently undergoing chemotherapy with an agent that forms cross-links between DNA strands. Serum studies show a creatinine concentration of 2.1 mg/dL and a blood urea nitrogen concentration of 30 mg/dL. Urine dipstick of a clean-catch midstream specimen shows 2+ protein and 1+ glucose. Prior to initiation of chemotherapy, her laboratory values were within the reference range. In addition to hydration, administration of which of the following would most likely have prevented this patient's current condition?