Neoplasia — MCQs

A 56-year-old man presents to his physician’s office with a sudden increase in urinary frequency. During the past month, he has observed that he needs more frequent bathroom breaks. This is quite unusual as he hasn’t been consuming extra fluids. He reports feeling generally unwell over the past 2 months. He has lost over 7 kg (15.4 lb) of weight and has also been feeling progressively fatigued by the end of the day. He also has a persistent cough and on a couple of occasions, he noticed blood streaks on his napkin. In addition to all of this, he has been feeling weak with frequent muscle cramps during the day. He has never been diagnosed with any medical condition in the past. He doesn’t drink but has smoked 2 packs of cigarettes daily for the last 25 years. Prior to his appointment, he took a couple of tests. The results are given below: Hemoglobin (Hb) 13.1 g/dL Serum creatinine 0.8 mg/dL Serum urea 13 mg/dL Serum sodium 129 mEq/L Serum potassium 3.2 mEq/L His chest X-ray shows a central nodule with some hilar thickening. The physician recommends a biopsy of the nodule. Which of the following histological patterns is the nodule most likely to exhibit?

A 45-year-old male reports several years of asbestos exposure while working in the construction industry. He reports smoking 2 packs of cigarettes per day for over 20 years. Smoking and asbestos exposure increase the incidence of which of the following diseases?

A 51-year-old man presents to the emergency department with an episode of syncope. He was at a local farmer's market when he fainted while picking produce. He rapidly returned to his baseline mental status and did not hit his head. The patient has a past medical history of diabetes and hypertension but is not currently taking any medications. His temperature is 97.5°F (36.4°C), blood pressure is 173/101 mmHg, pulse is 82/min, respirations are 14/min, and oxygen saturation is 98% on room air. Physical exam is notable for clear breath sounds and a S4 heart sound. Rectal exam reveals a firm and nodular prostate that is non-tender and a fecal-occult sample that is negative for blood. Which of the following is this patient's presentation most concerning for?

A 67-year-old man comes to the physician because of urinary frequency, dysuria, and blood in his urine. He has also had a 4.5-kg (10-lb) weight loss over the past 3 months and has been feeling more fatigued than usual. He smoked one pack of cigarettes daily for 40 years but quit 2 years ago. A urinalysis shows 3+ blood. Cystoscopy shows an irregular mass on the bladder wall; a biopsy is taken. Which of the following histologic findings would indicate the worst survival prognosis?

A 74-year-old man with a history of encephalomyelitis, ataxia, and nystagmus has a new diagnosis of small cell carcinoma of the lung (T2, N1, M0) is admitted to the hospital due to painless loss of vision in his right eye. A full workup reveals optic neuritis and uveitis in the affected eye. Which of the following antibodies is most likely to be present in the serum of the patient?

A 60-year-old woman is brought to the emergency department by ambulance after suffering a generalized tonic-clonic seizure. The seizure lasted 2 minutes, followed by a short period of unresponsiveness and loud breathing. Her blood pressure is 130/80 mm Hg, the heart rate is 76/min, and the respiratory rate is 15/min and regular. On physical examination, the patient is confused but follows commands and cannot recall recent events. The patient does not present with any other neurological deficits. T1/T2 MRI of the brain demonstrates a hypointense, contrast-enhancing mass within the right frontal lobe, surrounded by significant cerebral edema. Which of the following would you expect in the tissue surrounding the described lesion?

A 61-year-old man comes to the physician because of a 2-month history of a cough productive of clear mucoid sputum. He has smoked one pack of cigarettes daily for 33 years. Physical examination shows no abnormalities. Chest x-ray shows a 2-cm solid nodule in the periphery of the lower left lobe. A bronchial biopsy of the mass shows numerous mucin-filled epithelial cells lining the alveolar basement membrane. The cells have prominent nucleoli, coarse chromatin, and some cells have multiple nuclei. Which of the following is the most likely diagnosis?

A 62-year-old man comes to the physician because of a growth on his penis that has been gradually increasing in size over the last year. He was diagnosed with HIV 10 years ago. He has been divorced for 25 years and has had “at least 30 sexual partners” since. Physical examination shows a nontender 2.5-cm ulcerated lesion with an erythematous base on the dorsum of the glans. There is firm left inguinal lymphadenopathy. A biopsy of the lesion shows small uniform basophilic cells with central necrosis that invade into the corpus cavernosum. This patient's condition is most likely associated with which of the following pathogens?

A 61-year-old man comes to the physician because of a 6-month history of epigastric pain and a 9-kg (20-lb) weight loss. He feels full and bloated even after eating small portions of food. His hemoglobin concentration is 9.5 g/dL with a mean corpuscular volume of 78 μm3. Test of the stool for occult blood is positive. Esophagogastroduodenoscopy shows a 2-cm raised lesion with central ulceration on the lesser curvature of the stomach. Histologic examination of a gastric biopsy specimen from the lesion is most likely to show which of the following?

A 59-year-old Caucasian man presents with a one-month history of left flank fullness and pain. The patient has stable angina, which is controlled with medications including atorvastatin, metoprolol, and aspirin. His vital signs are within normal limits. BMI is 32 kg/m2. Clinical examination reveals a 10 x 10-cm palpable mass in the left flank. Testicular examination indicates left varicocele. Laboratory parameters are as follows: Urine Blood 3+ WBC none RBC 65/hpf without dysmorphic features Abdominal CT scan confirms the presence of a large solid mass originating in the left kidney with impingement on the left renal vein. Based on the most likely diagnosis, which of the following is considered a risk factor in this patient?