Question 1

Question

A 45-year-old woman with type 2 diabetes mellitus presents for routine follow-up. Her physician prescribes exenatide, a GLP-1 receptor agonist, to improve glycemic control. The drug increases insulin secretion and decreases glucagon release in a glucose-dependent manner. Through which signal transduction mechanism does GLP-1 receptor activation primarily lead to insulin secretion in pancreatic beta cells?

Accepted Answer

Activation of adenylyl cyclase leading to increased cAMP levels

Answer

Opening of ligand-gated calcium channels

Answer

Activation of phospholipase C leading to IP3 and DAG production

Answer

Direct activation of protein kinase C

Answer

Activation of receptor tyrosine kinase leading to MAP kinase cascade

Signal transduction pathways — MCQs

Signal transduction pathways — MCQs

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