Mood Disorders Practice Questions

Q: A persistent feeling of guilt is characteristic of which of the following conditions?

Depression. **Explanation:** **1. Why Depression is Correct:** Persistent and pervasive feelings of **guilt** are a core symptom of **Major Depressive Disorder (MDD)**. According to the ICD-10 and DSM-5 criteria, "excessive or inappropriate guilt" (which may be delusional) is one of the psychological symptoms of depression. This guilt often manifests as self-reproach or ruminating over minor past failings. It is a key component of **Beck’s Cognitive Triad**, which includes negative views about the self, the world, and the future. **2. Why Other Options are Incorrect:** * **Mania:** Characterized by an abnormally elevated, expansive, or irritable mood. Instead of guilt, patients typically exhibit **inflated self-esteem or grandiosity**. * **Obsessive-Compulsive Disorder (OCD):** While patients may feel distress or anxiety regarding their obsessions, the hallmark is repetitive, intrusive thoughts and ritualistic behaviors, not a primary persistent mood of guilt. * **Schizophrenia:** Primarily a thought disorder characterized by delusions, hallucinations, and disorganized speech. While "guilt" can be a theme in a delusion, it is not a defining characteristic of the illness itself. **Clinical Pearls for NEET-PG:** * **Beck’s Cognitive Triad:** Negative thoughts about Self, World, and Future (High-yield for Depression). * **Depressive Delusions:** In severe depression, guilt can reach delusional proportions (e.g., believing one is responsible for a world disaster). * **Nihilistic Delusions (Cotard Syndrome):** Belief that one is dead or parts of the body do not exist; often seen in severe psychotic depression. * **Biological Markers:** Look for "Early morning awakening" and "Diurnal variation of mood" (worse in the morning) as classic somatic signs of depression.

Q: Which of the following is a clinical feature of mania?

Elated mood. **Explanation:** The core clinical feature of **Mania** is a distinct period of abnormally and persistently elevated, expansive, or irritable mood. In mania, the **Elated mood** (Option B) is characterized by intense happiness, optimism, and enthusiasm that is often out of proportion to the individual’s circumstances. This is frequently accompanied by increased energy, pressured speech, flight of ideas, and decreased need for sleep. **Analysis of Incorrect Options:** * **Anhedonia (Option A):** This refers to the inability to feel pleasure in normally pleasurable activities. It is a hallmark symptom of **Depression**, not mania. * **Avolition (Option B):** This is a "negative symptom" characterized by a lack of motivation or ability to initiate and persist in self-directed purposeful activities. It is commonly seen in **Schizophrenia** and severe depressive episodes. **High-Yield Clinical Pearls for NEET-PG:** * **Diagnostic Criteria (DSM-5/ICD-11):** For a diagnosis of Mania, the symptoms must last for at least **one week** (or any duration if hospitalization is required). For Hypomania, the duration is at least **4 days**. * **The "DIG FAST" Mnemonic:** * **D**istractibility * **I**ndiscretion (excessive involvement in pleasurable activities with high risk) * **G**randiosity * **F**light of ideas * **A**ctivity increase (Psychomotor agitation) * **S**leep (decreased need) * **T**alkativeness (Pressured speech) * **Key Distinction:** The presence of **psychotic features** (delusions/hallucinations) or the need for **hospitalization** automatically classifies the episode as Mania, never Hypomania.

Q: All of the following are true regarding depression except?

Most common psychiatric disorder overall. **Explanation:** The correct answer is **B**, as it is a false statement. While depression is a leading cause of disability worldwide, **Anxiety Disorders** are statistically the most common psychiatric disorders in the general population. Depression (Major Depressive Disorder) is the most common **mood disorder**, but not the most common psychiatric disorder overall. **Analysis of other options:** * **A. More common in women:** This is true. The prevalence of depression is approximately twice as high in women as in men (2:1 ratio), likely due to hormonal differences, psychosocial stressors, and higher rates of reporting. * **C. Most common age group is middle age:** This is true. While depression can occur at any age, the mean age of onset is in the late 30s to 40s. The peak prevalence is typically seen in the middle-aged population. * **D. Is genetic in origin:** This is true. Depression has a strong hereditary component. First-degree relatives of patients with MDD are 2-3 times more likely to develop the condition. Heritability is estimated at approximately 30-40%. **High-Yield Clinical Pearls for NEET-PG:** * **Most common psychiatric disorder:** Anxiety Disorders (specifically Specific Phobias). * **Most common mood disorder:** Major Depressive Disorder (MDD). * **Lifetime prevalence of MDD:** Approximately 15-17%. * **Neurotransmitter changes:** Decreased levels of Serotonin (5-HT), Norepinephrine, and Dopamine. * **Sleep changes in depression:** Reduced REM latency (earlier onset of REM), increased REM duration, and decreased slow-wave sleep.

Q: Which of the following formal thought disorders is classical in mania?

Flight of ideas. **Explanation:** **Flight of Ideas** is the hallmark formal thought disorder seen in **Mania**. It is characterized by a rapid succession of thoughts where the connection between ideas is maintained (logical) but shifted quickly due to distractibility or playfulness (clanging, punning). The patient speaks incessantly (pressure of speech), but a listener can usually follow the train of thought, albeit with difficulty. **Analysis of Incorrect Options:** * **Loosening of Associations (Knight’s Move Thinking):** This is the hallmark of **Schizophrenia**. Unlike flight of ideas, the transitions between thoughts are illogical and lack any discernible connection, making the speech incoherent to the listener. * **Neologism:** This refers to the coining of new words that have meaning only to the patient. It is a feature of **Schizophrenia**, not typically mania. * **Circumstantiality:** Here, the patient includes excessive, unnecessary detail but eventually reaches the point. While it can be seen in mania or personality disorders, it is most classically associated with **Epilepsy** (interictal personality) or organic brain syndromes. **Clinical Pearls for NEET-PG:** * **Pressure of Speech:** The objective sign of rapid, loud, and difficult-to-interrupt speech often accompanying flight of ideas in mania. * **Tangentiality:** The patient moves away from the topic and never returns to the original point (common in Schizophrenia). * **Word Salad:** The most extreme form of loosening of associations where speech is a random jumble of words. * **Key Distinction:** In *Flight of Ideas*, the link between ideas is **understandable**; in *Loosening of Associations*, the link is **lost**.

Q: All of the following are true about mania except?

Word salad. **Explanation:** The correct answer is **D. Word salad**. In psychiatry, **Word Salad** (schizophasia) is a severe form of thought form disorder characterized by a random jumble of words that lack any logical or grammatical connection. It is a hallmark feature of **Schizophrenia** (specifically disorganized type) rather than Mania. **Analysis of Options:** * **A. Elevated mood:** This is the core emotional feature of Mania. The mood is typically described as euphoric, expansive, or irritable, lasting for at least one week. * **B. Flight of ideas:** This is the classic **thought form disorder** seen in Mania. It involves a rapid succession of thoughts where ideas are connected by chance associations (e.g., clanging or punning), but a thin thread of logic usually remains, unlike word salad. * **C. Delusions of grandeur:** These are common **thought content disorders** in Mania. Patients have inflated self-esteem and believe they possess special powers, wealth, or a unique relationship with a deity or famous person. **Clinical Pearls for NEET-PG:** 1. **DIGFAST Mnemonic for Mania:** **D**istractibility, **I**ndiscretion (excessive involvement in pleasurable activities), **G**randiosity, **F**light of ideas, **A**ctivity increase, **S**leep deficit (decreased need for sleep), **T**alkativeness (pressured speech). 2. **Pressure of Speech:** In Mania, speech is rapid, loud, and difficult to interrupt. 3. **Distinction:** While "Flight of Ideas" is characteristic of **Mania**, "Loosening of Associations" and "Word Salad" are more characteristic of **Schizophrenia**. 4. **Hypomania vs. Mania:** Hypomania lasts ≥4 days, does not require hospitalization, and lacks psychotic features. Mania lasts ≥1 week or requires hospitalization.

Q: What is paradoxical suicide?

Suicide observed after the initiation of treatment.. ### Explanation **Paradoxical suicide** refers to a phenomenon where a patient with severe depression commits suicide shortly after starting treatment (pharmacotherapy or psychotherapy) or during the early stages of recovery. **Why Option D is Correct:** In severe depression, patients often suffer from **psychomotor retardation**—a state where they lack the physical energy and motivation to carry out a suicide plan, despite having suicidal ideation. When treatment (like SSRIs) begins, physical energy and motivation often improve **before** the depressive mood and hopelessness lift. This "energy gap" creates a window where the patient now has the physical drive to act on their pre-existing suicidal thoughts. This is why the risk of suicide paradoxically increases in the first few weeks of antidepressant therapy. **Why Other Options are Incorrect:** * **Options A, B, and C:** While family members and caregivers of depressed patients are at a higher risk for depression and "caregiver burnout," their suicidal behavior is not termed "paradoxical suicide." These would be categorized under the genetic or environmental transmission of mental illness. **High-Yield Clinical Pearls for NEET-PG:** * **The "Danger Zone":** The highest risk for paradoxical suicide is typically within the first **10 to 14 days** of starting antidepressants. * **Black Box Warning:** The FDA has a black box warning for SSRIs regarding increased suicidal thoughts and behaviors in children, adolescents, and young adults (up to age 24). * **Clinical Management:** Always monitor patients closely during the initial phase of treatment. If a patient suddenly appears "energetic" but still expresses hopelessness, it is a major red flag. * **ECT:** Electroconvulsive Therapy (ECT) is often preferred in actively suicidal patients because it works faster than drugs to bridge this dangerous gap.

Q: Which of the following is not a part of Beck's triad?

Sleeplessness. **Explanation:** **Beck’s Cognitive Triad** is a core concept in the cognitive theory of depression developed by Aaron Beck. It describes three specific patterns of negative thinking that maintain depressive symptoms. The triad consists of negative views about: 1. **The Self (Worthlessness):** The individual perceives themselves as defective, inadequate, or lacking the necessary requirements for happiness. 2. **The World/Environment (Helplessness):** The individual interprets ongoing experiences in a negative way, believing the world makes exorbitant demands or presents insuperable obstacles. 3. **The Future (Hopelessness):** The individual anticipates that current difficulties or suffering will continue indefinitely. **Why Sleeplessness is the correct answer:** Sleeplessness (Insomnia) is a **somatic (physical) symptom** of depression, not a cognitive one. While it is a common diagnostic criterion for Major Depressive Disorder (MDD) in the DSM-5, it is not part of Beck’s psychological model of cognitive distortions. **Analysis of Incorrect Options:** * **Hopelessness:** Represents the negative view of the **future**. It is a strong predictor of suicidal intent. * **Worthlessness:** Represents the negative view of the **self**. * **Helplessness:** Represents the negative view of the **world/current situation**, where the individual feels they have no control over their environment. **High-Yield Clinical Pearls for NEET-PG:** * **Cognitive Behavioral Therapy (CBT):** Aimed at identifying and restructuring these three negative schemas. * **Learned Helplessness:** A related but distinct concept developed by **Martin Seligman** (based on animal models). * **Suicide Risk:** Among the triad, **Hopelessness** is the most significant indicator of long-term suicidal risk.

Q: Which of the following is associated with neurotic depression?

Usually associated with anxiety. **Explanation:** In psychiatry, **Neurotic Depression** (also known as Dysthymia or Persistent Depressive Disorder in modern terminology) is characterized by a chronic, low-grade depressive state that is often triggered by external stressors or personality factors. **1. Why Option A is Correct:** Neurotic depression is frequently characterized by a "mixed" clinical picture. Unlike psychotic or endogenous depression, it is **usually associated with anxiety**, irritability, and somatic complaints. Patients often remain in touch with reality but struggle with chronic dissatisfaction and emotional instability. **2. Why the other options are incorrect:** * **Option B (ECT):** Electroconvulsive Therapy (ECT) is indicated for severe, biological, or "melancholic" depression, especially when there is a high suicide risk or catatonia. It is rarely, if ever, used for neurotic depression, which responds better to psychotherapy and SSRIs. * **Option C (Endogenous depression):** This is the opposite of neurotic depression. Endogenous depression arises from internal biological factors (not external stressors), presents with "vegetative" symptoms (weight loss, early morning awakening), and is often more severe. * **Option D (Bipolar):** Neurotic depression is typically unipolar. Bipolar disorder involves distinct episodes of mania or hypomania, which are absent in neurotic/dysthymic patterns. **High-Yield Clinical Pearls for NEET-PG:** * **Neurotic vs. Psychotic Depression:** In neurotic depression, reality testing is intact, and there are no delusions or hallucinations. * **Diurnal Variation:** In endogenous depression, symptoms are worse in the morning; in neurotic depression, symptoms often worsen as the day progresses (**evening worsening**). * **Treatment:** The mainstay for neurotic depression is a combination of **Cognitive Behavioral Therapy (CBT)** and Pharmacotherapy (SSRIs).

Q: All of the following are features of depression except?

Elation. **Explanation:** The core clinical feature of **Depression (Major Depressive Disorder)** is a persistent low mood, loss of interest (anhedonia), and decreased energy. **Elation** (Option D) is the correct answer because it is the hallmark of **Mania**, not depression. Elation refers to a state of extreme happiness, euphoria, and confidence, which is diametrically opposed to the depressive state. **Analysis of Options:** * **Nihilistic Delusions (Cotard’s Syndrome):** These are common in severe psychotic depression. Patients believe they are dead, their internal organs are rotting, or that the world no longer exists. * **Diurnal Variation:** This is a classic "biological" symptom of melancholic depression. Typically, the mood is **worst in the morning** and improves slightly as the day progresses. * **Suicidal Tendency:** This is the most serious complication of depression. It stems from feelings of hopelessness, worthlessness, and helplessness. **NEET-PG High-Yield Pearls:** 1. **ICD-11/DSM-5 Criteria:** Symptoms must last for at least **2 weeks** for a diagnosis of a depressive episode. 2. **Beck’s Cognitive Triad:** Includes negative views about the **Self, the World, and the Future**. 3. **Biological Markers:** Depression is associated with decreased levels of Serotonin, Norepinephrine, and Dopamine, and increased levels of **Cortisol** (Dexamethasone Suppression Test failure). 4. **Treatment:** SSRIs are the first-line treatment; ECT is the most effective treatment for severe depression with high suicidal risk or nihilistic delusions.

Question 1

A persistent feeling of guilt is characteristic of which of the following conditions?

Accepted Answer

Depression

Answer

Obsessive-compulsive disorder (OCD)

Answer

Mania

Answer

Schizophrenia

Question 2

A 40-year-old female presented with agitated depression, attempted suicide, and feelings of guilt. What is the first-line treatment?

Accepted Answer

Pentotal interview to resolve guilt

Answer

Electroconvulsive therapy (ECT)

Answer

Psychotherapy

Answer

Antidepressant medication

Question 3

Which of the following is a clinical feature of mania?

Accepted Answer

Elated mood

Answer

Anhedonia

Answer

Avolition

Answer

All of the above

Question 4

All of the following are true regarding depression except?

Accepted Answer

Most common psychiatric disorder overall

Answer

More common in women

Answer

Most common age group is middle age

Answer

Is genetic in origin

Question 5

Which of the following formal thought disorders is classical in mania?

Accepted Answer

Flight of ideas

Answer

Loosening of associations

Answer

Neologism

Answer

Circumstantiality

Question 6

All of the following are true about mania except?

Accepted Answer

Word salad

Answer

Elevated mood

Answer

Flight of ideas

Answer

Delusions of grandeur

Question 7

What is paradoxical suicide?

Accepted Answer

Suicide observed after the initiation of treatment.

Answer

Suicide observed in caretakers of individuals with depression.

Answer

Suicide observed in children of individuals with depression.

Answer

Suicide observed in parents of individuals with depression.

Question 8

Which of the following is not a part of Beck's triad?

Accepted Answer

Sleeplessness

Answer

Hopelessness

Answer

Worthlessness

Answer

Helplessness

Question 9

Which of the following is associated with neurotic depression?

Accepted Answer

Usually associated with anxiety

Answer

Treated by ECT

Answer

Endogenous depression

Answer

Usually bipolar

Question 10

All of the following are features of depression except?

Accepted Answer

Elation

Answer

Nihilistic delusions

Answer

Diurnal variation in mood

Answer

Suicidal tendency

Mood Disorders — MCQs

Mood Disorders — MCQs

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