NEET-PG 2020 Practice Questions

Q: Enzyme activated by decrease in Insulin: glucagon ratio:

Glucose 6 phosphatase. ***Glucose 6 phosphatase*** - A decreased **insulin:glucagon ratio** signifies a catabolic state, promoting glucose release into the blood. - **Glucose-6-phosphatase** is the key enzyme in **gluconeogenesis** and **glycogenolysis** in the liver, dephosphorylating **glucose-6-phosphate** to **free glucose**, which can then be exported from the liver. *PFK* - **Phosphofructokinase (PFK)** is a key regulatory enzyme in **glycolysis**, which is inhibited in a state of low insulin:glucagon ratio. - Its activity would decrease, not increase, to reduce glucose utilization. *Glucokinase* - **Glucokinase** phosphorylates glucose to **glucose-6-phosphate** in the liver, trapping it for metabolism; its activity is increased by high insulin levels. - In a low insulin:glucagon ratio, its activity would be reduced to conserve glucose. *Hexokinase* - **Hexokinase** phosphorylates glucose in most peripheral tissues but has a lower Km for glucose than glucokinase, becoming saturated even at low glucose concentrations. - Its activity is not primarily regulated by the insulin:glucagon ratio; it is generally involved in glucose uptake for cellular energy needs.

Q: Vector for Zika virus disease is:

Aedes Aegypti. ***Aedes aegypti*** - The **Aedes aegypti mosquito** is the primary vector responsible for transmitting the Zika virus to humans. - This mosquito species is also known to transmit other arboviruses, including **dengue** and **chikungunya** viruses. *Culex* - **Culex mosquitoes** are known vectors for diseases such as **West Nile virus** and **Japanese encephalitis**. - They are generally not considered primary vectors for the Zika virus. *Phlebotomus* - **Phlebotomus (sandflies)** are vectors for parasitic diseases, most notably **leishmaniasis**. - They are not involved in the transmission of viral infections like Zika. *Anopheles stephensi* - **Anopheles mosquitoes**, particularly *Anopheles stephensi*, are the main vectors for **malaria**. - They do not play a role in the transmission of the Zika virus.

Q: Partial closure of the nose is performed in which condition?

Atrophic rhinitis. ***Atrophic rhinitis*** - **Partial closure of the nose** (Young's operation or naris plasty) is a surgical procedure used to reduce the size of the nasal passages and improve airflow in patients with atrophic rhinitis. - This condition involves progressive **atrophy of the nasal mucosa** and turbinates, leading to dryness, crusting, paradoxical obstruction, and often a foul odor. *Vasomotor rhinitis* - This condition involves **non-allergic rhinitis** triggered by environmental changes, temperature shifts, or irritants, causing symptoms like sneezing, rhinorrhea, and nasal congestion. - Management typically involves **avoidance of triggers**, nasal corticosteroids, or anticholinergic sprays, not surgical closure of the nose. *Allergic rhinitis* - Caused by an ** IgE-mediated immune response** to airborne allergens, leading to inflammation of the nasal mucosa, sneezing, itching, rhinorrhea, and congestion. - Treatment focuses on **allergen avoidance**, antihistamines, and nasal corticosteroids; surgical modification of nasal passages is not indicated. *Occupational rhinitis* - This form of rhinitis is caused by exposure to **irritants or allergens in the workplace**, leading to nasal symptoms similar to allergic or non-allergic rhinitis. - Management involves **identifying and avoiding the offending agent** at work, and medical treatments like nasal sprays, but not surgical narrowing of the nostrils.

Q: Which of the following is not a clinical presentation of Pituitary Apoplexy?

Hypertension. ***Hypertension*** - Pituitary apoplexy often leads to **adrenal insufficiency** due to damage to the pituitary gland, which in turn causes **hypotension**, not hypertension. - The sudden onset of severe pituitary dysfunction typically results in a drop in blood pressure rather than an increase. *Vomiting* - **Vomiting** is a common symptom of pituitary apoplexy, often accompanying severe headache due to increased intracranial pressure or hormonal imbalances [1]. - The sudden mass effect of the hemorrhage or infarction can irritate surrounding structures, leading to nausea and vomiting. *Headache* - A **sudden, severe headache** is the most common presenting symptom of pituitary apoplexy, often described as a "thunderclap" headache [1]. - This intense headache is caused by rapid expansion of the pituitary mass and irritation of the **dura mater**. *Hypotension* - **Hypotension** is a classic feature of pituitary apoplexy, resulting from acute **adrenal insufficiency** where insufficient ACTH leads to decreased cortisol production [1]. - This hormonal deficiency impairs the body's ability to maintain blood pressure and respond to stress [1].

Q: Which of the following is NOT the feature of secondary ACTH deficiency?

Hyperpigmentation. ***Hyperpigmentation*** - **Hyperpigmentation** occurs in **primary adrenal insufficiency** (Addison's disease) due to high levels of **ACTH** and co-secreted **melanocyte-stimulating hormone (MSH)** [1]. - In **secondary ACTH deficiency**, ACTH levels are low, so there is no increased stimulation of melanocytes, and thus **hyperpigmentation is absent** [2]. *Anorexia* - **Anorexia** can be a feature of both **primary** and **secondary adrenal insufficiency** due to the general catabolic effects of **cortisol deficiency** and overall endocrine dysfunction. - Reduced cortisol can lead to altered metabolism and appetite, contributing to loss of appetite [2]. *Fatigue* - **Fatigue** is a common and prominent symptom in both **primary** and **secondary adrenal insufficiency** due to **cortisol deficiency** [2]. - Lack of adequate cortisol affects energy metabolism, muscle function, and overall well-being, leading to profound tiredness. *Hypotension* - **Hypotension** is more characteristic of **primary adrenal insufficiency** due to both **cortisol** and **aldosterone deficiency** [1]. - In **secondary ACTH deficiency**, aldosterone secretion is typically preserved (as it's regulated by the **renin-angiotensin system**), but severe **cortisol deficiency** can still contribute to mild hypotension [2].

Q: A woman with 18 weeks gestation presented to the OPD. On abdominal examination, the uterine size was 16 weeks. On USG, oligohydramnios was found, which of the following is suspected?

Renal agenesis. ***Renal agenesis*** - **Oligohydramnios** (low amniotic fluid) and a **smaller-than-expected uterine size** at 18 weeks gestation are strong indicators of fetal renal agenesis. - Fetal kidneys are crucial for producing amniotic fluid through urine excretion, so their absence or severe malfunction leads to insufficient fluid. *Jaundice* - Not directly associated with **oligohydramnios** or a smaller uterine size. - While it can occur in utero, it doesn't cause a reduction in amniotic fluid volume. *Fetal anemia* - Often associated with **hydrops fetalis** and **polyhydramnios** (excess amniotic fluid), due to increased cardiac output and fluid retention, rather than oligohydramnios. - Doesn't typically present with a uterus smaller than expected for gestational age. *Anencephaly* - A neural tube defect characterized by the absence of a major portion of the brain and skull. - It is usually associated with **polyhydramnios** (excess amniotic fluid) due to impaired fetal swallowing, making it inconsistent with the given findings.

Q: The lab reports of a patient given below: pH = 7.2, HCO3 = 10 mEq/L, PCO2 = 30 mmHg. This exemplifies which of the following disorders?

Metabolic acidosis. ***Metabolic acidosis*** - The pH of 7.2 is acidic, and the **bicarbonate (HCO3) of 10 mEq/L** is significantly low (normal: 22-28 mEq/L), indicating a primary metabolic disturbance causing acidosis. - The **PCO2 of 30 mmHg** is also low (normal: 35-45 mmHg), which represents **partial respiratory compensation** through hyperventilation to blow off CO2 and raise pH. - This is a classic example of **metabolic acidosis with respiratory compensation**. *Metabolic alkalosis* - This condition would be characterized by a **high pH** and a **high bicarbonate (HCO3)** level, which is the opposite of the given values. - The body would attempt to compensate by increasing PCO2 through hypoventilation. *Respiratory acidosis* - This would present with a **low pH** and a **high PCO2** (>45 mmHg), indicating a primary respiratory problem leading to CO2 retention and acid accumulation. - Metabolic compensation would show elevated HCO3, not the low HCO3 (10 mEq/L) seen here. *Respiratory alkalosis* - This condition is characterized by a **high pH** (>7.45) and a **low PCO2**, due to excessive ventilation causing CO2 elimination. - While PCO2 is low in the given scenario, the pH is acidic (7.2), not alkalotic, ruling out this diagnosis.

Q: Chest radiograph obtained from a male patient with hypertension. What could be the probable diagnosis?

Coarctation of Aorta. ***Coarctation of Aorta*** - **Coarctation of the aorta** is a congenital narrowing of the aorta, often presenting with **hypertension** in the upper extremities. - Chest X-rays can show **rib notching** (due to collateral circulation via intercostal arteries) and a **"3" sign** (indentation of the aorta at the coarctation site). *Mitral Stenosis* - **Mitral stenosis** primarily affects the **mitral valve**, leading to left atrial enlargement and pulmonary congestion. - While it can manifest as dyspnea and **pulmonary hypertension**, it does not typically present with the same radiographic findings as coarctation or systemic hypertension alone. *Transposition of Great Arteries* - **Transposition of the great arteries** is a cyanotic congenital heart defect, where the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. - It presents in infancy with **cyanosis** and a characteristic **"egg on a string"** appearance on chest X-ray due to narrow mediastinum and abnormal great vessel alignment. *Aortic Stenosis* - **Aortic stenosis** is the narrowing of the aortic outflow tract, which can cause symptoms like angina, syncope, and heart failure. - While it can lead to **left ventricular hypertrophy** and widened pulse pressure, it is not typically associated with the specific radiographic findings of coarctation and the isolated hypertension in upper limbs.

Q: A patient presents with abdominal pain, blood in stools and a palpable mass on examination. A Barium Study was performed, probable diagnosis is?

Intussusception. ***Intussusception*** - This condition is characterized by a "telescoping" of one segment of the intestine into another, which can lead to **abdominal pain**, **rectal bleeding** (often described as "currant jelly" stools), and a **palpable sausage-shaped mass** on examination. - A barium study (specifically a **barium enema**) is often diagnostic and can also be therapeutic for intussusception, revealing a **coiled spring appearance** or an obstruction. *Volvulus* - Volvulus involves the **twisting of a loop of bowel** around its mesentery, often presenting with sudden onset, severe **abdominal pain**, vomiting, and constipation. - While it can cause an obstruction and pain, a palpable mass and bloody stools are less common initial findings compared to intussusception. *Meckel's Diverticulum* - Meckel's diverticulum is a **congenital outpouching** of the small intestine that can be asymptomatic or cause complications like **gastrointestinal bleeding** (due to ectopic gastric mucosa), obstruction, or diverticulitis. - While it can cause painless rectal bleeding, a palpable mass and acute, intermittent abdominal pain are not typical primary presentations for an uncomplicated Meckel’s diverticulum. *Diverticulitis* - Diverticulitis is the **inflammation of diverticula** (small pouches in the colon), typically presenting with **left lower quadrant abdominal pain**, fever, and changes in bowel habits. - While it can cause bleeding, a palpable mass is less common unless there's an abscess, and the clinical picture does not align as strongly with the "currant jelly stool" and classic palpable mass of intussusception.

Question 1

Enzyme activated by decrease in Insulin: glucagon ratio:

Accepted Answer

Glucose 6 phosphatase

Answer

PFK

Answer

Glucokinase

Answer

Hexokinase

Question 2

"MONICA Project" is associated with:

Accepted Answer

Monitoring of trends and determinants in cardiovascular disease

Answer

Risk factor intervention trials for CVD

Answer

Lipid research clinics study

Answer

Oslo diet/smoking intervention study

Question 3

Vector for Zika virus disease is:

Accepted Answer

Aedes Aegypti

Answer

Culex

Answer

Phlebotomus

Answer

Anopheles stephensi

Question 4

Partial closure of the nose is performed in which condition?

Accepted Answer

Atrophic rhinitis

Answer

Vasomotor rhinitis

Answer

Allergic rhinitis

Answer

Occupational rhinitis

Question 5

Which of the following is not a clinical presentation of Pituitary Apoplexy?

Accepted Answer

Hypertension

Answer

Vomiting

Answer

Headache

Answer

Hypotension

Question 6

Which of the following is NOT the feature of secondary ACTH deficiency?

Accepted Answer

Hyperpigmentation

Answer

Anorexia

Answer

Fatigue

Answer

Hypotension

Question 7

A woman with 18 weeks gestation presented to the OPD. On abdominal examination, the uterine size was 16 weeks. On USG, oligohydramnios was found, which of the following is suspected?

Accepted Answer

Renal agenesis

Answer

Jaundice

Answer

Fetal anemia

Answer

Anencephaly

Question 8

The lab reports of a patient given below: pH = 7.2, HCO3 = 10 mEq/L, PCO2 = 30 mmHg. This exemplifies which of the following disorders?

Accepted Answer

Metabolic acidosis

Answer

Metabolic alkalosis

Answer

Respiratory acidosis

Answer

Respiratory alkalosis

Question 9

Chest radiograph obtained from a male patient with hypertension. What could be the probable diagnosis?

Accepted Answer

Coarctation of Aorta

Answer

Mitral Stenosis

Answer

Transposition of Great Arteries

Answer

Aortic Stenosis

Question 10

A patient presents with abdominal pain, blood in stools and a palpable mass on examination. A Barium Study was performed, probable diagnosis is?

Accepted Answer

Intussusception

Answer

Volvulus

Answer

Meckel's Diverticulum

Answer

Diverticulitis

NEET-PG 2020

Biochemistry

Community Medicine

ENT

Internal Medicine

Obstetrics and Gynecology

Physiology

Radiology

Surgery