NEET-PG 2020 Practice Questions

Q: Which of the following is the richest source of vitamin B12?

Meat. ***Meat*** - **Meat** and other animal products are the primary natural dietary sources of **vitamin B12** (cobalamin). - This is because vitamin B12 is synthesized by bacteria and accumulates in animal tissues. *Green leafy vegetables* - **Green leafy vegetables** are excellent sources of many vitamins and minerals, such as **folate** and **vitamin K**, but they do not contain vitamin B12. - Vitamin B12 is essentially absent in plant-based foods unless they are fortified or contaminated. *Corn oil* - **Corn oil** is a vegetable oil primarily composed of fats and is a source of **vitamin E** and fatty acids, but it does not contain vitamin B12. - Oils derived from plants lack intrinsic vitamin B12 content. *Sunflower oil* - Similar to corn oil, **sunflower oil** is a plant-based oil rich in **vitamin E** and unsaturated fatty acids, but it contains **no vitamin B12**. - Plant oils are not a source of vitamin B12, which is almost exclusively found in animal products.

Q: Maximum work hours for a person including overtime under the Factories Act:

60 hours. ***60 hours*** - Under the **Factories Act**, the total number of hours worked by an adult in any week, including **overtime**, shall not exceed **sixty hours**. - This limit is crucial for ensuring workers' health and safety, preventing **over-fatigue**, and promoting a reasonable work-life balance. *48 hours* - The **Factories Act** stipulates that no adult worker shall be required or allowed to work in a factory for more than **forty-eight hours in any week**. - However, this limit refers to the standard work week and **does not include overtime**, which is allowed within an additional limit. *50 hours* - This option is incorrect as it does not align with the maximum weekly work hours, including overtime, stipulated by the **Factories Act**. - There is no specific provision in the **Factories Act** that sets a combined standard and overtime work limit at exactly 50 hours per week. *100 hours* - This option is significantly higher than the maximum work hours allowed by the **Factories Act**, including overtime. - Working 100 hours per week would be a serious violation of labor laws, as it would expose workers to **severe health risks** and **occupational hazards**.

Q: Elderly man with a long-standing mole on his face that is increasing in size and showing an irregular border. Diagnosis:

Lentigo maligna. ***Lentigo maligna*** - This type of melanoma commonly affects **elderly individuals** and presents as a **slowly enlarging, irregularly bordered, flat or slightly raised pigmented lesion** on sun-exposed areas like the face. - It often has a **long radial growth phase** before progressing to invasive lentigo maligna melanoma. *Superficial spreading melanoma* - While common, it typically presents on the **trunk or extremities** and has a faster growth rate compared to lentigo maligna. - It often appears as a **flat, asymmetrical lesion with varied colors and irregular borders**, but the age and location details point away from this. *Nodular melanoma* - This is an **aggressive form** that grows vertically from the start, presenting as a **dark, raised, often ulcerated nodule** and typically has a shorter history of rapid growth. - It lacks the characteristic long-standing, flat growth pattern described in the elderly patient's face. *Acral melanoma* - This rare type occurs on the **palms, soles, or under the nails (subungual)**, not typically on the face. - It often appears as a **pigmented streak or patch** in these acral locations.

Q: 60-year-old female with a history of intermittent bleeding. What is the diagnosis based on the ultrasound image?

Endometrial polyp. ***Endometrial polyp*** - The ultrasound image shows a well-defined, **echogenic focal lesion within the endometrial cavity**, which is characteristic of an endometrial polyp. - In a 60-year-old female with intermittent bleeding, a polyp is a common cause of **postmenopausal bleeding** and is often identified as an intracavitary mass on ultrasound. - Endometrial polyps appear as **focal, hyperechoic or isoechoic masses** with a smooth contour projecting into the endometrial cavity. *Ca endometrium* - **Endometrial carcinoma** typically appears as diffuse endometrial thickening (>4-5 mm in postmenopausal women), irregular endometrial-myometrial interface, or heterogeneous endometrial echoes, often with evidence of myometrial invasion. - While bleeding is a cardinal symptom of endometrial carcinoma, the distinct **focal, well-circumscribed nature** of the lesion on ultrasound is less typical for carcinoma, which tends to be more diffuse and irregular. *Submucosal fibroid* - A **submucosal fibroid** (leiomyoma) is a benign smooth muscle tumor originating from the myometrium that protrudes into the endometrial cavity. - While it can appear as an intracavitary mass and cause abnormal bleeding, fibroids often have a more **heterogeneous or hypoechoic appearance** with posterior acoustic shadowing, compared to the isoechoic to hyperechoic appearance of a polyp. - The feeding vessel sign (blood flow at the base) is more characteristic of polyps than fibroids. *Endometrial hyperplasia* - **Endometrial hyperplasia** presents as **diffuse, uniform endometrial thickening** rather than a focal intracavitary mass. - It typically shows homogeneous increased echogenicity of the entire endometrium without a discrete, well-defined lesion as seen with a polyp. - While it can cause postmenopausal bleeding, the focal nature of the lesion in this case makes hyperplasia less likely.

Q: Which of the following vitamins, when taken at higher doses, can cause cystoid macular edema?

Niacin. ***Niacin*** - High doses of **niacin (nicotinic acid)**, particularly the extended-release forms used for lipid management, are known to cause **cystoid macular edema (CME)**. - The mechanism is thought to involve **vasodilation** and metabolic changes in the retinal pigment epithelium. *Vitamin A* - While essential for vision, **excessive vitamin A** intake (hypervitaminosis A) can lead to symptoms like **headache**, **blurred vision**, and skin changes, but not typically cystoid macular edema. - Deficiency of vitamin A can cause **night blindness** and xerophthalmia. *Vitamin D* - High doses of vitamin D can lead to **hypercalcemia**, causing symptoms such as nausea, vomiting, and kidney stones. - It does not directly cause **cystoid macular edema**. *Vitamin E* - **Excessive vitamin E** intake can interfere with **blood clotting** and increase the risk of bleeding, especially in individuals on anticoagulants. - There is no established link between high-dose vitamin E and **cystoid macular edema**.

Q: Which of the following is not considered a prokinetic agent?

Diphenylmethane. Diphenylmethane derivatives (e.g., bisacodyl, sodium picosulfate) are stimulant laxatives, not prokinetic agents. While they do increase colonic motility, they work by direct stimulation of the colonic mucosa and myenteric plexus, causing increased water secretion and peristalsis [3]. Prokinetic agents specifically enhance coordinated gastrointestinal motility through modulation of neurotransmitters (acetylcholine, dopamine, serotonin, motilin), whereas laxatives work through different mechanisms (osmotic effects, stimulation, bulk formation). Therefore, diphenylmethane derivatives are classified as laxatives, not prokinetics. Dopamine antagonist - Dopamine antagonists like metoclopramide and domperidone block D2 receptors in the chemoreceptor trigger zone and GI tract, enhancing acetylcholine release and promoting gastric emptying [2]. - They are commonly used as prokinetic agents and antiemetics [2]. 5HT4 agonist - 5HT4 agonists (e.g., cisapride, prucalopride) stimulate serotonin receptors in the enteric nervous system, increasing acetylcholine release and enhancing colonic motility [1]. - They are effective prokinetic agents for conditions like chronic constipation and gastroparesis [1]. Macrolides - Certain macrolide antibiotics, such as erythromycin, act as motilin receptor agonists at sub-antibiotic doses. - By mimicking motilin, they stimulate gastric and intestinal contractions (phase III of migrating motor complex), functioning as prokinetic agents.

Q: What is the most common illicit drug that causes dependence?

Cannabis. ***Cannabis*** - **Cannabis** is the most widely used illicit drug globally, and despite common misconceptions, it can certainly lead to **cannabis use disorder** characterized by dependence. - The high prevalence of its use contributes to it being the illicit drug that most commonly causes clinical dependence, as a larger user base means more individuals will develop problematic use patterns. *Cocaine* - While cocaine is known for its **highly addictive potential** and rapid development of dependence, its overall prevalence of use is lower than cannabis. - The intense psychological dependence associated with cocaine can lead to severe withdrawal symptoms and compulsive drug-seeking behavior. *Heroin* - **Heroin**, an opioid, is highly addictive, causing both **physical and psychological dependence** very quickly due to its potent effects on the brain's reward system. - However, its illicit use is less widespread compared to cannabis, making it responsible for fewer overall cases of dependence. *Amphetamine* - **Amphetamines** also have a high potential for **psychological dependence**, leading to compulsive use and significant withdrawal symptoms upon cessation. - Like cocaine and heroin, the overall number of people who use amphetamines illicitly is significantly lower than those who use cannabis.

Q: The chest radiograph shown below is from a 25-year-old male patient presenting with hypertension. The image demonstrates bilateral inferior rib notching. What is the most likely diagnosis?

Coarctation of Aorta. ***Coarctation of Aorta*** - The chest radiograph shows findings consistent with **rib notching**, which is a classic sign of coarctation of the aorta due to increased collateral circulation through intercostal arteries. - The history of **hypertension** in a male patient, especially if presenting at a younger age or with differential blood pressures between upper and lower extremities, strongly suggests coarctation of the aorta. *Tetralogy of Fallot* - Characterized by a **boot-shaped heart** due to right ventricular hypertrophy and pulmonary outflow obstruction. - Would typically present with **cyanosis** and decreased pulmonary vascular markings, not rib notching or isolated hypertension. *Ebstein's Anomaly* - Involves apical displacement of the **tricuspid valve**, leading to atrialization of the right ventricle and severe tricuspid regurgitation. - Chest X-rays often show **severe cardiomegaly** (huge heart due to right atrial enlargement) and decreased pulmonary vascularity, which are not depicted here. *TAPVC* - Total anomalous pulmonary venous connection (TAPVC) involves all pulmonary veins draining into the systemic circulation. - The classic chest X-ray finding for supracardiac TAPVC is a **"snowman" or "figure of 8" sign** due to dilated anomalous vessels and superior vena cava, which is absent in this image.

Question 1

30 years old came with complaints of easy fatigability, exertional dyspnea, and weight loss. She also complains of frequent falls. physical examination revealed there was a bilateral decrease in vibration sense. Her hemoglobin levels were 8.2g%. She was treated with folate. Her anemia improved but neurological symptoms worsened. Which of the following is the most probable reason for her condition?

Accepted Answer

Folate therapy caused rapid use of Vit B12 stores aggravating symptoms

Answer

Vitamin B6 deficiency unmasked by folate treatment.

Answer

Impaired folate metabolism in the central nervous system.

Answer

Malabsorption of folate due to gastrointestinal issues.

Question 2

Which of the following is the richest source of vitamin B12?

Accepted Answer

Meat

Answer

Green leafy vegetables

Answer

Corn oil

Answer

Sunflower oil

Question 3

Maximum work hours for a person including overtime under the Factories Act:

Accepted Answer

60 hours

Answer

48 hours

Answer

50 hours

Answer

100 hours

Question 4

Elderly man with a long-standing mole on his face that is increasing in size and showing an irregular border. Diagnosis:

Accepted Answer

Lentigo maligna

Answer

Superficial spreading melanoma

Answer

Nodular melanoma

Answer

Acral melanoma

Question 5

60-year-old female with a history of intermittent bleeding. What is the diagnosis based on the ultrasound image?

Accepted Answer

Endometrial polyp

Answer

Ca endometrium

Answer

Submucosal fibroid

Answer

Endometrial hyperplasia

Question 6

A lady on treatment for infertility developed ascites, abdominal pain, and dyspnea. The ultrasound image is shown below. What is the most likely diagnosis?

Accepted Answer

OHSS

Answer

PCOS

Answer

Theca lutein cyst

Answer

Mucinous cystadenomas

Question 7

Which of the following vitamins, when taken at higher doses, can cause cystoid macular edema?

Accepted Answer

Niacin

Answer

Vitamin A

Answer

Vitamin D

Answer

Vitamin E

Question 8

Which of the following is not considered a prokinetic agent?

Accepted Answer

Diphenylmethane

Answer

Dopamine antagonist

Answer

5HT4 agonist

Answer

Macrolides

Question 9

What is the most common illicit drug that causes dependence?

Accepted Answer

Cannabis

Answer

Cocaine

Answer

Heroin

Answer

Amphetamine

Question 10

The chest radiograph shown below is from a 25-year-old male patient presenting with hypertension. The image demonstrates bilateral inferior rib notching. What is the most likely diagnosis?

Accepted Answer

Coarctation of Aorta

Answer

Tetralogy of Fallot

Answer

Ebstein's Anomaly

Answer

TAPVC

NEET-PG 2020

Biochemistry

Community Medicine

Dermatology

Obstetrics and Gynecology

Pharmacology

Psychiatry

Radiology