NEET-PG 2012 Practice Questions

Q: In the case of a penile injury, which of the following structures prevents the extravasation of blood?

Buck's fascia. ***Buck's fascia*** - **Buck's fascia** is a strong, fibrous sheath that surrounds the **corpora cavernosa** and **corpus spongiosum**, acting as a confining layer. - In cases of **penile injury**, such as a penile fracture, rupture of the tunica albuginea leads to bleeding [1]. Buck's fascia contains this extravasated blood, preventing its spread beyond the penis and resulting in a characteristic **"eggplant" deformity** [1]. *Fascia of Camper* - The **fascia of Camper** is the superficial fatty layer of the anterior abdominal wall's superficial fascia. - It is continuous with the superficial perineal fascia but does not directly cover the erectile tissues of the penis. *Fascia transversalis* - The **fascia transversalis** is a deep fascia lining the inner aspect of the anterior abdominal wall, beneath the transversus abdominis muscle. - It plays a role in forming the posterior wall of the inguinal canal and is not directly involved in containing blood within the penis after an injury. *None of the options* - This option is incorrect because Buck's fascia specifically fulfills the function described, isolating blood within the penile shaft.

Q: Which organelle is primarily affected in Fabry's disease?

Lysosome. ***Lysosome*** - Fabry's disease is a **lysosomal storage disorder** caused by a deficiency of the enzyme **alpha-galactosidase A**. - This enzyme deficiency leads to the accumulation of **globotriaosylceramide (Gb3)** within lysosomes in various cells throughout the body. *Endoplasmic Reticulum* - The **endoplasmic reticulum** is involved in protein synthesis and folding, and lipid metabolism. - While cellular stress from Gb3 accumulation can indirectly affect the ER, it is not the primary organelle involved in the storage of the accumulated substrate in Fabry's disease. *Golgi apparatus* - The **Golgi apparatus** modifies, sorts, and packages proteins and lipids. - It is not the site of primary pathology or substrate accumulation in lysosomal storage diseases. *Cell membrane* - The **cell membrane** regulates passage of substances into and out of the cell. - While lysosomal dysfunction can ultimately impact overall cell function, the cell membrane itself is not the organelle where the undigested substrate accumulates in Fabry's disease.

Q: Muir–Torre syndrome shows

Sebaceous gland tumors. ***Sebaceous gland tumors*** - **Muir-Torre syndrome** is a genetic condition characterized by the presence of at least one **sebaceous gland tumor** (adenoma, epithelioma, or carcinoma) and at least one internal malignancy. - It is considered a variant of **Lynch syndrome (hereditary nonpolyposis colorectal cancer - HNPCC)**, stemming from germline mutations in **DNA mismatch repair genes**. *Intestinal polyps (associated with familial adenomatous polyposis)* - While Lynch syndrome (to which Muir-Torre is related) does involve an increased risk of colorectal cancer, **multiple intestinal polyps** are the hallmark of **Familial Adenomatous Polyposis (FAP)**. - FAP is caused by a mutation in the **APC gene**, distinct from the mismatch repair gene mutations seen in Muir-Torre syndrome. *Lisch nodules (associated with Neurofibromatosis type 1)* - **Lisch nodules** are benign **iris hamartomas** typically found in patients with **Neurofibromatosis type 1 (NF1)**. - NF1 is a neurocutaneous disorder caused by a mutation in the **NF1 gene**, presenting with café-au-lait spots, neurofibromas, and optic gliomas, which are unrelated to Muir-Torre syndrome. *Hyperelastic joints (associated with Ehlers-Danlos syndrome)* - **Hyperelasticity of joints** and skin is a characteristic feature of **Ehlers-Danlos syndrome (EDS)**, a group of heritable disorders affecting connective tissue. - EDS is caused by defects in **collagen synthesis or processing**, and its clinical manifestations are distinct from the mucocutaneous and internal malignancies seen in Muir-Torre syndrome.

Q: The immunoglobulin most commonly involved in Multiple Myeloma is:

IgG. ***IgG*** - In Multiple Myeloma, the most commonly involved immunoglobulin is **IgG**, which is often produced in excess by malignant plasma cells [1][2]. - The presence of **monoclonal IgG** in serum is a key indicator of this malignancy, evident in diagnostic tests like serum protein electrophoresis. *IgM* - While **elevated IgM** levels can occur in other conditions like Waldenström's macroglobulinemia, it is not typically associated with Multiple Myeloma [2]. - IgM is produced by a different type of plasma cell and does not reflect the classic presentation of Multiple Myeloma. *IgA* - Although **IgA** can be involved in some cases of Multiple Myeloma, it is much less common than IgG [1][2]. - Patients with predominately **IgA Multiple Myeloma** are relatively rare compared to those with IgG. *IgD* - **IgD** myeloma is a very rare type of Multiple Myeloma, accounting for less than 2% of cases [1][2]. - It is not typically associated with the classic symptoms and conditions that characterize the more common IgG or IgA forms. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus, pp. 608-609. [2] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Blood And Bone Marrow Disease, pp. 616-617.

Q: Tetany is seen in

Respiratory alkalosis. ***Respiratory alkalosis*** - **Respiratory alkalosis** is caused by **hyperventilation**, which leads to a decrease in arterial partial pressure of carbon dioxide (**PaCO2**). - This decrease in PaCO2 causes an increase in pH (alkalemia) and a shift in the albumin-bound calcium equilibrium, reducing the amount of **ionized calcium** in the blood, leading to symptoms of **hypocalcemia** such as tetany. *Respiratory acidosis* - **Respiratory acidosis** is characterized by an increase in PaCO2 and a decrease in pH due to inadequate ventilation, which would not typically cause tetany. - In fact, the acidosis would tend to increase **ionized calcium** levels, thereby counteracting any tendency towards symptoms of hypocalcemia. *Metabolic acidosis* - **Metabolic acidosis** involves a decrease in bicarbonate concentration and pH, often due to conditions like diabetic ketoacidosis or lactic acidosis. - Similar to respiratory acidosis, the acidic environment of **metabolic acidosis** tends to increase **ionized calcium** levels, making tetany unlikely. *Hyperkalemia* - **Hyperkalemia** refers to elevated potassium levels in the blood, which primarily affects cardiac and neuromuscular function. - While it can cause muscle weakness and cardiac arrhythmias, it does not directly lead to **tetany**, which is a sign of **hypocalcemia**.

Q: Step ladder pattern of gas shadow is seen in

Intestinal obstruction. ***Intestinal obstruction*** - A **step-ladder pattern** of gas shadows is a classic radiological sign seen in **small bowel obstruction** due to dilated, fluid-filled loops of small bowel stacked on top of each other. - This pattern results from the accumulation of gas and fluid proximal to the obstruction, causing dilated bowel loops to arrange horizontally. *Gastric outlet obstruction* - This condition primarily results in a **dilated stomach** with fluid and gas, not typically a step-ladder pattern in the small bowel. - Vomiting is usually a prominent symptom, and imaging would show a large fluid-filled stomach. *Duodenal obstruction* - Causes dilatation of the stomach and duodenum, leading to a "**double-bubble sign**" (dilated stomach and proximal duodenum). - It does not typically produce the extensive, stacked small bowel loops seen in a step-ladder pattern. *Sigmoid volvulus* - Characterized by a distinctive large, dilated loop of sigmoid colon, often described as a "**coffee bean sign**" or an **inverted U-shape**. - This is a large bowel obstruction and does not typically present with a step-ladder pattern of small bowel gas.

Q: Road traffic accident (RTA) with multiple fractures - initial treatment would be:

Airway management. ***Airway management*** - In trauma, **establishing and maintaining a patent airway** is the absolute priority, as compromised breathing can lead to rapid deterioration and death. - The **ABCs (Airway, Breathing, Circulation)** of trauma care dictate that airway intervention precedes other life-saving measures. *Management of shock* - While crucial, **managing shock (C)** follows **airway (A)** and **breathing (B)** in the primary survey of trauma care. - Addressing profound shock without a patent airway can be ineffective and leads to irreversible damage. *Splinting of limbs* - **Splinting fractures** is important for pain control, preventing further injury, and minimizing blood loss in open fractures, but it is not an immediate life-saving intervention. - This falls under the **secondary survey** or definitive management, after life-threatening issues have been addressed. *Cervical spine protection* - **Cervical spine protection** is essential in trauma to prevent further neurological injury and is performed simultaneously with airway management (often with in-line stabilization). - However, a patent airway is the **most immediate life-sustaining intervention** if the airway is compromised.

Q: What type of burn is characterized by flash burn, tenderness, redness, and pain?

First degree burn. ***First degree burn*** - Characterized by **tenderness**, **redness**, and **pain** without blistering. - Involves only the **epidermis**, typically from a **flash burn** or brief contact with a hot object. *Scalded burn* - A type of burn caused by **hot liquid or steam**, not a characteristic of a specific burn depth. - Can be superficial or deep, depending on the **temperature** and **duration of exposure**. *Second degree burn* - Involves the **epidermis and dermis**, presenting with **blisters**, severe pain, and sometimes a wet, weeping appearance. - Often heals with scarring, unlike first-degree burns. *Fourth degree burn* - The most severe type of burn, extending through **all layers of skin** into underlying **muscle**, **tendons**, or **bone**. - Often appears charred or black, and victims may feel little pain due to extensive nerve damage.

Q: Esophageal manometry is useful in diagnosing all of the following conditions EXCEPT:

Malignancy (not typically diagnosed with this test). ***Malignancy (not typically diagnosed with this test)*** - **Esophageal manometry** evaluates the **motor function** of the esophagus, measuring pressure changes during swallowing. - **Malignancy**, such as esophageal cancer, is primarily diagnosed with **endoscopy with biopsy** and imaging studies, not by assessing motility. *Achalasia (a motility disorder)* - **Esophageal manometry** is the **gold standard** for diagnosing achalasia, characterized by **absent peristalsis** in the esophageal body and **incomplete relaxation of the lower esophageal sphincter (LES)** [1]. - High-resolution manometry shows elevated **integrated relaxation pressure (IRP)** and often pan-esophageal pressurization. *Diffuse esophageal spasm (a motility disorder)* - This condition is also diagnosed by **esophageal manometry**, which reveals simultaneous, **non-peristaltic contractions** of high amplitude, often interspersed with normal peristalsis [1]. - It may also show **premature contractions** and **multiple rapid swallows** triggering spasm. *Assessment of esophageal motility prior to surgery for GERD* - **Manometry** is routinely performed before **anti-reflux surgery (e.g., Nissen fundoplication)** to rule out underlying esophageal motility disorders that could complicate surgery or worsen symptoms post-operatively [1]. - Identifying conditions like **achalasia** or **scleroderma** would contraindicate a standard fundoplication, as dysphagia could worsen [1].

Q: Which muscle flap is commonly used for autologous breast reconstruction after mastectomy?

Latissimus dorsi. ***Latissimus dorsi*** - The **latissimus dorsi** muscle is commonly used in **autologous breast reconstruction** due to its rich blood supply and ample tissue volume which can be transferred as a **pedicled flap** to the chest. - This flap includes muscle, skin, and subcutaneous fat, providing a good aesthetic outcome for **breast mound reconstruction** after mastectomy. *Deltopectoral* - The **deltopectoral flap** is primarily used for **head and neck reconstruction**, specifically for oral cavity and pharyngeal defects. - It involves muscle and skin from the **chest and shoulder region**, but its size and location make it less suitable for comprehensive breast reconstruction. *Serratus anterior* - The **serratus anterior** muscle is occasionally used as a **free flap** for small soft tissue defects, but it is not typically the first choice for large-volume breast reconstruction. - Its primary role is in **shoulder movement** and it does not provide sufficient tissue bulk for a complete breast mound. *Trapezius* - The **trapezius flap** is more commonly employed in **head and neck reconstruction** or for covering defects in the posterior shoulder region. - While it offers a good blood supply, its bulk and orientation are not ideal for **breast reconstruction**, which requires a more anterior and hemispheric shape.

Question 1

In the case of a penile injury, which of the following structures prevents the extravasation of blood?

Accepted Answer

Buck's fascia

Answer

Fascia of camper

Answer

Fascia transversalis

Answer

None of the options

Question 2

Which organelle is primarily affected in Fabry's disease?

Accepted Answer

Lysosome

Answer

Endoplasmic Reticulum

Answer

Golgi apparatus

Answer

Cell membrane

Question 3

Muir–Torre syndrome shows

Accepted Answer

Sebaceous gland tumors

Answer

Intestinal polyps

Answer

Lisch nodules

Answer

Hyperelastic joints

Question 4

The immunoglobulin most commonly involved in Multiple Myeloma is:

Accepted Answer

IgG

Answer

IgM

Answer

IgA

Answer

IgD

Question 5

Tetany is seen in

Accepted Answer

Respiratory alkalosis

Answer

Respiratory acidosis

Answer

Metabolic acidosis

Answer

Hyperkalemia

Question 6

Step ladder pattern of gas shadow is seen in

Accepted Answer

Intestinal obstruction

Answer

Gastric outlet obstruction

Answer

Duodenal obstruction

Answer

Sigmoid volvulus

Question 7

Road traffic accident (RTA) with multiple fractures - initial treatment would be:

Accepted Answer

Airway management

Answer

Management of shock

Answer

Splinting of limbs

Answer

Cervical spine protection

Question 8

What type of burn is characterized by flash burn, tenderness, redness, and pain?

Accepted Answer

First degree burn

Answer

Scalded burn

Answer

Second degree burn

Answer

Fourth degree burn

Question 9

Esophageal manometry is useful in diagnosing all of the following conditions EXCEPT:

Accepted Answer

Malignancy (not typically diagnosed with this test)

Answer

Achalasia (a motility disorder)

Answer

Diffuse esophageal spasm (a motility disorder)

Answer

Assessment of esophageal motility prior to surgery for GERD

Question 10

Which muscle flap is commonly used for autologous breast reconstruction after mastectomy?

Accepted Answer

Latissimus dorsi

Answer

Deltopectoral

Answer

Serratus anterior

Answer

Trapezius

NEET-PG 2012

Anatomy

Biochemistry

Dermatology

Pathology

Physiology

Radiology

Surgery