Biochemistry
2 questionsEffect of environment on genes is called?
Which amino acid in Jowar is responsible for its pellagragenic effect?
NEET-PG 2012 - Biochemistry NEET-PG Practice Questions and MCQs
Question 591: Effect of environment on genes is called?
- A. Euthenics
- B. Positive Eugenics
- C. Negative Eugenics
- D. Epigenetics (Correct Answer)
Explanation: ***Epigenetics*** - **Epigenetics** refers to heritable changes in **gene expression** that do not involve alterations to the underlying **DNA sequence**. - These changes are often influenced by **environmental factors**, such as diet, stress, and exposure to toxins, which can affect how genes are turned on or off. *Positive Eugenics* - **Positive eugenics** aims to improve the human population by encouraging the reproduction of individuals deemed to have "desirable" traits. - This concept is ethically controversial and focuses on directed breeding rather than environmental gene influence. *Negative Eugenics* - **Negative eugenics** aims to reduce the prevalence of "undesirable" traits in the human population by discouraging or preventing the reproduction of individuals deemed to possess them. - Like positive eugenics, this is a highly controversial concept focused on limiting reproduction based on perceived genetic quality. *Euthenics* - **Euthenics** is a movement focused on improving human well-being and development by improving living conditions and the environment. - While it acknowledges the impact of the environment, it focuses on societal and lifestyle improvements rather than the direct molecular changes in gene expression.
Question 592: Which amino acid in Jowar is responsible for its pellagragenic effect?
- A. Leucine (Correct Answer)
- B. Lysine
- C. Tryptophan
- D. Methionine
Explanation: ***Leucine*** - A high intake of **leucine**, an essential amino acid, interferes with the metabolism of **tryptophan** and niacin, leading to **pellagra**. - Jowar (sorghum) contains high levels of leucine, which, when it forms a major part of the diet, can induce **niacin deficiency**. *Lysine* - Lysine is an essential amino acid and is generally considered to be in **limited supply** in many cereal grains, making it a desirable amino acid to increase in diets. - It does not directly contribute to the pellagragenic effect; rather, a deficiency in lysine can be a nutritional concern. *Tryptophan* - Tryptophan is a **precursor to niacin (Vitamin B3)** in the body; a deficiency in tryptophan can lead to pellagra. - The high leucine content in jowar interferes with the conversion of tryptophan to niacin, thus exacerbating niacin deficiency. *Methionine* - Methionine is an **essential sulfur-containing amino acid** important for various metabolic functions and protein synthesis. - It is not directly implicated in the pellagragenic effect associated with high jowar consumption.
Community Medicine
5 questionsWhich occupational exposure may cause sterility in females ?
Berksonian bias is a type of ?
In pediatric growth assessment, what is the typical relationship observed between height and weight in healthy children?
National Leprosy Eradication Programme was started in -
Multi-purpose worker scheme in India was introduced following the recommendation of ?
NEET-PG 2012 - Community Medicine NEET-PG Practice Questions and MCQs
Question 591: Which occupational exposure may cause sterility in females ?
- A. Lead
- B. Carbon monoxide
- C. Mercury
- D. Agricultural insecticides (Correct Answer)
Explanation: ***Agricultural insecticides*** - Exposure to **organochlorine** and **organophosphate** insecticides can have significant **reproductive toxicity** in females, leading to **infertility** or **sterility**. - These chemicals can disrupt **hormonal balance**, interfere with **ovarian function**, cause **menstrual irregularities**, and lead to **developmental toxicity** in offspring. - Well-documented occupational hazard in agricultural workers with chronic exposure. *Lead* - Lead is a well-established **reproductive toxicant** affecting **both males and females**. - In females, lead causes **menstrual irregularities**, **ovarian dysfunction**, **reduced fertility**, **spontaneous abortions**, and can contribute to sterility. - It disrupts the **hypothalamic-pituitary-ovarian axis** and has direct **gonadotoxic effects**. - While agricultural insecticides are more specifically associated with female sterility in occupational contexts, lead is also a significant reproductive hazard. *Carbon monoxide* - Carbon monoxide poisoning primarily causes **hypoxia** by binding to hemoglobin, forming **carboxyhemoglobin**. - It does not directly cause **sterility** in females; its main reproductive concern relates to **fetal hypoxia** and adverse pregnancy outcomes during exposure. *Mercury* - Mercury exposure, particularly **methylmercury**, is a known **neurotoxin** and can cause **developmental abnormalities**. - While it can affect pregnancy outcomes and cause **menstrual disorders** at high exposures, it is not typically cited as a primary occupational cause of **female sterility** compared to agricultural insecticides.
Question 592: Berksonian bias is a type of ?
- A. Selection bias (Correct Answer)
- B. Information bias
- C. Interviewer bias
- D. Recall bias
Explanation: ***Selection bias*** - **Berkson's bias** is a form of **selection bias** that arises in studies conducted using hospital data. - It occurs when the probability of admission to a hospital or inclusion in a study is conditional on both exposure and disease status, leading to a **flawed association** between them. *Interviewer bias* - **Interviewer bias** is a type of **information bias** where the interviewer's expectations or knowledge about the study or participants influence the way information is sought or recorded. - This typically affects the **data collection process** and not the selection of participants. *Information bias* - **Information bias** is a broad category of biases that arise from **systematic errors in measurement** or classification of exposure or disease. - While Berkson's bias can lead to misinformation, its root cause is in how subjects are selected, not how data on those subjects is collected after selection. *Recall bias* - **Recall bias** is a type of **information bias** where there are systematic differences in the way participants **recall past events or exposures**. - It is particularly common in **case-control studies** where individuals with a disease may remember exposures differently than healthy controls.
Question 593: In pediatric growth assessment, what is the typical relationship observed between height and weight in healthy children?
- A. Negative Correlation
- B. No Correlation
- C. Inverse Relationship
- D. Positive Correlation (Correct Answer)
Explanation: ***Positive Correlation*** - In healthy children, as **height increases**, **weight generally also increases** in a predictable pattern, demonstrating a **positive correlation** between these two variables. - This is a fundamental aspect of normal pediatric growth, where both height and weight increase together as children develop. - The **correlation coefficient** between height and weight in healthy children is typically **strong and positive** (r > 0.7). *Negative Correlation* - A **negative correlation** would imply that as height increases, weight decreases, which contradicts normal growth patterns in healthy children. - This relationship might be observed in certain pathological conditions (e.g., severe malnutrition with stunting) but is not characteristic of normal development. *No Correlation* - Stating **no correlation** would mean that changes in height have no predictable linear relationship with changes in weight, which contradicts well-established growth data. - Height and weight are both key anthropometric indicators that are inherently linked during normal growth. *Inverse Relationship* - An **inverse relationship** is synonymous with a negative correlation, suggesting that as one variable increases, the other decreases. - This is incorrect for normal pediatric growth, where height and weight generally trend upwards together throughout childhood.
Question 594: National Leprosy Eradication Programme was started in -
- A. 1949
- B. 1955
- C. 1973
- D. 1983 (Correct Answer)
Explanation: **Correct: 1983** - The **National Leprosy Eradication Programme (NLEP)** was launched in India in **1983** - Its goal was to eliminate leprosy as a public health problem by reducing its prevalence rate to less than 1 case per 10,000 population - This marked the shift from control to eradication strategy with the introduction of **Multi-Drug Therapy (MDT)** *Incorrect: 1949* - This year is not associated with the inception of a national leprosy eradication program in India - While efforts against leprosy existed, a comprehensive national program was not established at this time *Incorrect: 1955* - The **National Leprosy Control Programme (NLCP)** was launched in India in **1955** - This was a control program, preceding the eradication program, focusing on diagnosis and treatment with Dapsone monotherapy - NLCP was later upgraded to NLEP in 1983 *Incorrect: 1973* - This year is not cited as the start date for the national leprosy eradication program in India - The focus shifted from control to eradication in 1983 with the adoption of WHO-recommended MDT
Question 595: Multi-purpose worker scheme in India was introduced following the recommendation of ?
- A. Srivastava Committee
- B. Bhore Committee
- C. Kartar Singh Committee (Correct Answer)
- D. Chadha Committee
Explanation: ***Kartar Singh Committee*** - The **Kartar Singh Committee** (1973) recommended the implementation of the **multi-purpose worker scheme** in India. - This scheme aimed to integrate several health services at the grassroots level through a single health worker. *Srivastava Committee* - The **Srivastava Committee** (1975) focused on the creation of a **Medical and Health Education Commission** to reform medical education. - It did not specifically recommend the multi-purpose worker scheme. *Bhore Committee* - The **Bhore Committee** (1946), also known as the Health Survey and Development Committee, recommended a comprehensive health service with an emphasis on preventive and curative care. - It laid conceptual groundwork for primary healthcare but did not specifically propose the multi-purpose worker scheme, which came much later. *Chadha Committee* - The **Chadha Committee** (1963) reviewed India's health infrastructure and medical education. - It focused on health center development and medical college expansion, not the multi-purpose worker scheme.
Ophthalmology
2 questionsWhat is the term for an abnormally eccentrically placed pupil?
The reduced effect of low astigmatism in dim light is primarily due to:
NEET-PG 2012 - Ophthalmology NEET-PG Practice Questions and MCQs
Question 591: What is the term for an abnormally eccentrically placed pupil?
- A. Polycoria
- B. Ectopia lentis
- C. Anisocoria
- D. Corectopia (Correct Answer)
Explanation: ***Corectopia*** - **Corectopia** refers to an **abnormally eccentrically placed pupil**, meaning the pupil is displaced from its normal central position within the iris. - This condition can be **congenital** or acquired due to trauma, inflammation, or surgery. *Polycoria* - **Polycoria** is a rare congenital anomaly characterized by the presence of **multiple pupils** in a single iris. - Each pupil typically has its own independent sphincter muscle. *Anisocoria* - **Anisocoria** is the condition where the **pupils are of unequal size**, meaning one pupil is larger or smaller than the other. - This can be physiological (normal) or pathological, indicating underlying neurological or ocular issues. *Ectopia lentis* - **Ectopia lentis** refers to the **displacement or dislocation of the natural lens** of the eye from its normal position. - It is often associated with systemic conditions like **Marfan syndrome** or trauma.
Question 592: The reduced effect of low astigmatism in dim light is primarily due to:
- A. Pupil dilatation
- B. Pupil constriction (Correct Answer)
- C. Increased curvature of lens
- D. Decreased curvature of lens
Explanation: ***Pupil constriction*** - In dim light conditions, patients with low astigmatism may experience **reduced symptoms** due to the **pinhole effect** of pupil constriction when they squint or strain to see better. - **Pupil constriction** limits light entry to the central optical zone, reducing the effect of irregular corneal curvature by creating a smaller aperture that acts like a **stenopic slit**. - This **pinhole effect** improves depth of focus and reduces blur from astigmatism by eliminating peripheral aberrant rays. - When viewing in dim light, patients naturally squint to improve clarity, which mimics pupil constriction and reduces astigmatic blur. *Pupil dilatation* - **Pupil dilatation** in dim light would actually *increase* astigmatic symptoms, not reduce them. - A larger pupil allows more peripheral rays to enter the eye, which pass through areas of the lens and cornea with greater refractive error. - This increases the blur circle and worsens the optical quality in uncorrected astigmatism. *Increased curvature of lens* - **Increased lens curvature** (accommodation) increases refractive power but does not correct the unequal curvature of different meridians that defines astigmatism. - This would not specifically reduce astigmatic blur in dim light conditions. *Decreased curvature of lens* - **Decreased lens curvature** reduces refractive power and is associated with relaxed accommodation. - This does not address the fundamental issue of unequal meridional refraction in astigmatism.
Pathology
1 questionsER positive status in carcinoma breast indicates?
NEET-PG 2012 - Pathology NEET-PG Practice Questions and MCQs
Question 591: ER positive status in carcinoma breast indicates?
- A. Prognosis (Correct Answer)
- B. Etiology
- C. Site
- D. None of the options
Explanation: ***Prognosis*** - **ER positive status** in breast cancer indicates a better prognosis, as these tumors often respond well to hormone therapy [1][2]. - Patients with **ER positive** breast cancer usually have a lower risk of metastasis compared to **ER negative** tumors, making the outcome more favorable [1]. *Site* - ER status does not provide information regarding the **anatomical location** of the breast cancer, as it can be present in different sites of the breast. - It primarily focuses on the **biologic characteristics** of the tumor rather than its site of occurrence [1]. *None* - Selecting 'None' suggests that ER positive status has no relevance, which is incorrect as it is significant for treatment and prognosis [1]. - It is a crucial indicator for deciding on **endocrine therapy**, impacting management strategies in breast cancer patients [1]. *Etiology* - ER positive status does not directly indicate the **cause** of breast cancer, as various genetic and environmental factors contribute to its development. - It mainly reflects tumor behavior and response to therapies, not the **underlying factors** that lead to the disease [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Breast, p. 1056. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Breast, pp. 1064-1066.